ES423827A1 - Procedure for preparing derivatives of penicilanico and cefalosporanic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing derivatives of penicilanico and cefalosporanic acids. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES423827A1 ES423827A1 ES423827A ES423827A ES423827A1 ES 423827 A1 ES423827 A1 ES 423827A1 ES 423827 A ES423827 A ES 423827A ES 423827 A ES423827 A ES 423827A ES 423827 A1 ES423827 A1 ES 423827A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- symbol
- carbonylamino
- salt
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure to prepare derivatives of penicillinic and cephalosporanic acids, of general formula: **(See formula)** wherein the symbol X represents a hydrogen atom or a lower hydroxy or alkanoyloxy group (preferably acetoxy) or the residue of a nucleophilic agent, such as an azido group, a carbamoyloxy group, an SZ group where Z represents a tetrazolyl group, thiadiazolllo, oxadiazolyl, isoxazolyl, imidazolyl, said heterocyclic groups optionally carrying lower alkyl groups, R represents a hydroxy or methoxy group, a chlorine or bromine atom, R1 represents a hydrogen, chlorine or bromine atom, R2 represents a hydrogen atom, chlorine or bromine, an amino group, a lower alkoxycarbonylamino group (for example, tert-butoxy-carbonylamino), a phenylalkoxy (lower) carbonylamino group, a p-ni triphenyl-coxy (lower) carbonylamino group or a p-methoxyphenylalkoxy group (lower) carbonylamino, a sulfonic acid group optionally transformed into an alkali, alkaline earth metal or amine metal salt, or R 2 represents a carbamoyl group and symbol E represents an atom of hydrogen, a salt-forming cation or a pharmaceutically acceptable ester residue, preferably a residue that provides the compounds of general formula (I) with improved absorption characteristics after oral administration to humans and animals; characterized in that it comprises reacting a salt, ester or amide of a 6-aminopenicillanic or 7-aminocephalosporanic acid, of the general formula **(See formula)** where X'is defined as X or represents a protected group that can easily become the groups covered by the definition of X after the acylation reaction, when the groups according to the symbol X can be influenced or can react under the conditions of reaction, and the symbol E'represents an easily separable protective ester residue, with a carboxylic acid halide, in an inert organic solvent; hydrolyze, hydrogenate, or react with basic or nucleophilic agents; to convert the ester, salt or amide of the product thus obtained into the corresponding substituted penicillinic or cephalosporanic acid; and optionally transforming the acids obtained into the corresponding salts or esters. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1018973A GB1464377A (en) | 1973-03-02 | 1973-03-02 | Penicillanic and cephalosporanic acid derivatives |
| GB183674 | 1974-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES423827A1 true ES423827A1 (en) | 1976-10-16 |
Family
ID=26237021
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423827A Expired ES423827A1 (en) | 1973-03-02 | 1974-03-02 | Procedure for preparing derivatives of penicilanico and cefalosporanic acids. (Machine-translation by Google Translate, not legally binding) |
| ES423828A Expired ES423828A1 (en) | 1973-03-02 | 1974-03-02 | Procedure for preparing derivatives of aminopenicilanico 6-substitute acids and aminocephalosparanico 7-substitute. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423828A Expired ES423828A1 (en) | 1973-03-02 | 1974-03-02 | Procedure for preparing derivatives of aminopenicilanico 6-substitute acids and aminocephalosparanico 7-substitute. (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5029591A (en) |
| AU (1) | AU6620274A (en) |
| DE (1) | DE2409949A1 (en) |
| ES (2) | ES423827A1 (en) |
| FR (1) | FR2219775A1 (en) |
| NL (1) | NL7402778A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54106495A (en) * | 1978-02-09 | 1979-08-21 | Dai Ichi Seiyaku Co Ltd | Cephem derivative |
| JPS6052713B2 (en) * | 1978-04-11 | 1985-11-20 | 三共株式会社 | 7-Methoxycephalosporin compound, its production method, and antibacterial agent containing the compound as a main ingredient |
| JPS6017368A (en) * | 1983-07-09 | 1985-01-29 | Toyota Motor Corp | Method and device for detecting short circuit of kickless cable |
| HU203243B (en) * | 1985-07-16 | 1991-06-28 | Biogal Gyogyszergyar | Process for producing cefalosporin derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1364453A (en) * | 1970-11-06 | 1974-08-21 | Gist Brocades Nv | Penicillanic and cepholosporanic acid derivatives |
-
1974
- 1974-03-01 NL NL7402778A patent/NL7402778A/xx unknown
- 1974-03-01 FR FR7407098A patent/FR2219775A1/en active Granted
- 1974-03-01 DE DE2409949A patent/DE2409949A1/en active Pending
- 1974-03-01 AU AU66202/74A patent/AU6620274A/en not_active Expired
- 1974-03-02 ES ES423827A patent/ES423827A1/en not_active Expired
- 1974-03-02 ES ES423828A patent/ES423828A1/en not_active Expired
- 1974-03-02 JP JP49024712A patent/JPS5029591A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5029591A (en) | 1975-03-25 |
| FR2219775A1 (en) | 1974-09-27 |
| ES423828A1 (en) | 1977-06-16 |
| FR2219775B1 (en) | 1978-07-28 |
| AU6620274A (en) | 1975-09-04 |
| DE2409949A1 (en) | 1974-09-05 |
| NL7402778A (en) | 1974-09-04 |
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