ES421977A1 - Substituted 5-sulphamylbenzoic acids - Google Patents

Substituted 5-sulphamylbenzoic acids

Info

Publication number
ES421977A1
ES421977A1 ES421977A ES421977A ES421977A1 ES 421977 A1 ES421977 A1 ES 421977A1 ES 421977 A ES421977 A ES 421977A ES 421977 A ES421977 A ES 421977A ES 421977 A1 ES421977 A1 ES 421977A1
Authority
ES
Spain
Prior art keywords
alkyl
formula
lower alkyl
carbon atoms
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421977A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES421977A1 publication Critical patent/ES421977A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A process for the preparation of the 2-substituted 5-sulfamyl benzoic acids of the formula ** (See formula) ** the amides, lower alkyl esters and pharmaceutically acceptable salts thereof, in which formula A is hydrogen, lower alkyl, cycloalkyl of 5 to 8 carbon atoms, benzyl or phenyl; B is where n has the value from 0 to 3; R2 and R3 are each hydrogen, chloro, bromo, alkyl or alkoxy of 1 to 4 carbon atoms, carboxy, trifluomethyl, phenyl, benzyl or benzyloxy; and W is amino, mono- or di-lower alkyl-amino, benzylamino, phenethylamino, piperidino, mono- or di-lower alkyl-piperidino, pyrrolidinyl, hexamethyleneimino or morpholino; and when A is hydrogen or lower alkyl, B is also lower alkyl or cycloalkyl of 5 to 8 carbon atoms; and A and B, when taken together with the nitrogen atom to which they are attached, form a heterocyclic ring selected from the group consisting of morpholino, thiomorpholine, piperazinyl, hexamethylenimino, heptamethyleneimino, octamethyleneimino, 3-azabicyclo [3,2,2 ] nonanyl, tetrahydropyridyl or mono- and di-substituted derivatives of said heterocyclic rings; the aforementioned substituents being alkyl, alkyloxy or alkyloxyalkyl of 1 to 4 carbon atoms in each alkyl, hydroxy, chloro, bromo, trifluomethyl, phenyl, tolyl, benzyl, benzyloxy, chloromethyl hydroxymethyl group; or the heterocyclic ring is unsubstituted piperidino or mono- or di-substituted piperidino, the substituents being alkyl, alkyloxy or alkyloxyalkyl of 1 to 4 carbon atoms in each alkyl, hydroxy, chloro, bromine, trifluomethyl, oxo, phenyl tolyl group, benzyl, benzyloxy, benzyloxymethyl, chloromethyl or hydroxymethyl, characterized by reacting a compound of the formula ** (See formula) ** with an amine of formula W-H in W is as defined above, and if desired, subsequently a compound of formula I in which A is hydrogen is converted to N-alkyl by N-alkylation. (Machine-translation by Google Translate, not legally binding)
ES421977A 1970-09-14 1974-01-02 Substituted 5-sulphamylbenzoic acids Expired ES421977A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7215670A 1970-09-14 1970-09-14

Publications (1)

Publication Number Publication Date
ES421977A1 true ES421977A1 (en) 1976-05-01

Family

ID=22105942

Family Applications (2)

Application Number Title Priority Date Filing Date
ES394830A Expired ES394830A1 (en) 1970-09-14 1971-09-06 Substituted 5-sulphamylbenzoic acids
ES421977A Expired ES421977A1 (en) 1970-09-14 1974-01-02 Substituted 5-sulphamylbenzoic acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES394830A Expired ES394830A1 (en) 1970-09-14 1971-09-06 Substituted 5-sulphamylbenzoic acids

Country Status (14)

Country Link
JP (1) JPS5512422B1 (en)
AT (1) AT323187B (en)
AU (1) AU468590B2 (en)
BE (1) BE772381A (en)
CA (1) CA983489A (en)
CH (2) CH552575A (en)
ES (2) ES394830A1 (en)
FR (1) FR2106514B1 (en)
GB (1) GB1353357A (en)
KE (1) KE2573A (en)
MY (1) MY7500253A (en)
NL (1) NL173400C (en)
SE (1) SE401673B (en)
ZA (1) ZA715851B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929803A (en) * 1974-05-28 1975-12-30 Pfizer Aryl carboxylic acids
WO1983000013A1 (en) * 1980-11-10 1983-01-06 Mochida Pharm Co Ltd Medicinal composition having an antiviral effect
JPS58192863A (en) * 1982-05-06 1983-11-10 Hodogaya Chem Co Ltd Novel aminosulfonylbenzoic acid ester derivative
SE8203878L (en) * 1981-06-22 1982-12-23 Mochida Pharm Co Ltd VIRUS COMPOSITION
AU539797B2 (en) * 1981-06-22 1984-10-18 Hodogaya Chemical Co. Ltd. Aminosulfonyl benzoic acid derivatives
JPS6323210U (en) * 1986-07-31 1988-02-16
DE3732374A1 (en) * 1987-09-25 1989-04-06 Basf Lacke & Farben ZINC, LEAD AND / OR CALCIUM SALTS OF CARBONIC ACIDS AND THE USE THEREOF AS A CORROSION PROTECT
JPH0248510U (en) * 1988-09-28 1990-04-04
PL353367A1 (en) * 1999-09-01 2003-11-17 Aventis Pharma Deutschland Gmbh Sulfonyl carboxamide derivatives, method for their production and their use as medicaments
DE19941559A1 (en) * 1999-09-01 2001-03-15 Aventis Pharma Gmbh Use of bissulfonamides for the preparation of medicaments for the prophylaxis or treatment of hyperlipidemia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH433378A (en) * 1962-03-09 1967-04-15 Ciba Geigy Process for the production of new anthranilic acid derivatives
FR1525352A (en) * 1967-04-06 1968-05-17 Ile De France Process for preparing 2-alkoxy-5-sulfamido-benzoic acids

Also Published As

Publication number Publication date
NL173400C (en) 1984-01-16
FR2106514A1 (en) 1972-05-05
AU468590B2 (en) 1976-01-15
ES394830A1 (en) 1974-12-01
NL173400B (en) 1983-08-16
JPS5512422B1 (en) 1980-04-02
BE772381A (en) 1972-03-09
DE2145686B2 (en) 1977-07-07
AT323187B (en) 1975-06-25
NL7112598A (en) 1972-03-16
KE2573A (en) 1975-10-31
FR2106514B1 (en) 1975-08-01
GB1353357A (en) 1974-05-15
ZA715851B (en) 1972-05-31
SE401673B (en) 1978-05-22
AU3308471A (en) 1973-03-08
CA983489A (en) 1976-02-10
CH552575A (en) 1974-08-15
CH569706A5 (en) 1975-11-28
MY7500253A (en) 1975-12-31
DE2145686A1 (en) 1972-04-20

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