ES421159A1 - Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES421159A1
ES421159A1 ES421159A ES421159A ES421159A1 ES 421159 A1 ES421159 A1 ES 421159A1 ES 421159 A ES421159 A ES 421159A ES 421159 A ES421159 A ES 421159A ES 421159 A1 ES421159 A1 ES 421159A1
Authority
ES
Spain
Prior art keywords
groups
carbon atoms
group
radicals
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421159A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GOLP UN SILBER SCHEIDEANSTALT
Original Assignee
GOLP UN SILBER SCHEIDEANSTALT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GOLP UN SILBER SCHEIDEANSTALT filed Critical GOLP UN SILBER SCHEIDEANSTALT
Publication of ES421159A1 publication Critical patent/ES421159A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of compounds of the general formula **(See formula)** in which the radicals R1 to R3 are the same or different and signify alcoholic groups with 1 to 3 carbon atoms, one of the radicals R1 to R3 being also a hydrogen atom or the acyl radical of an aliphatic carboxylic acid with 2 to 4 carbon atoms, R4 and R5 signify hydrogen or alcoholic groups with 1 to 3 carbon atoms, which can also together form through the two N atoms a saturated ring of six or seven members, R6, R7 and R8 are the same or different and mean hydrogen, halogen, alcohol groups with 1 to 8 carbon atoms, hydroxy groups, nitro groups, amino groups, cyano groups, carboxy groups, carbalkoxy groups with 1 to 6 carbon atoms, aliphatic, acylamino or acyloxy groups, saturated or unsaturated, with 1 to 6 carbon atoms, benzoxy, benzamino, cinnamoyloxy, cinnamoylamino groups, as well as benzoxy, benzamino, cinnamoyloxy, cinnamoylamino groups substituted with halogen atoms, alcoholic groups with 1 to 6 carbon atoms or groups alkoxy with 1 to 6 carbon atoms, a methylenedioxy group or alkoxy groups with 1 to 4 carbon atoms, these alkoxy groups may also be substituted with dialkohilamino radicals with saturated or unsaturated alkoxy groups with 1 to 6 carbon atoms, or with a homopiperidino, piperidino, morpholino radical and/or a hydroxy or alkoxy group of 1 to 3 carbon atoms, X is a methylene or imino group, which in each case can also be substituted with alcoholic groups with 1 to 4 carbon atoms, the indices m and n have a value of 1 or 0 and Ar is a monocyclic five or six-membered aromatic ring, optionally substituted with radicals R6, R7 and R8, of the formula **(See formula)** where Y = 0, S, NH, CH2, CH = N or CH = CH, being able to be present in the ring, in the case of a 5-membered ring, also a second nitrogen atom, or Ar is a system of aromatic bicyclic ring optionally substituted with radicals R6, R7 and R8 of the formula **(See formula)** in which Y has the meanings mentioned above and the 5-membered ring may also contain a second nitrogen atom, of its salts and quaternary compounds, characterized in that a compound of the general formula is reacted **(See formula)** with a compound of the general formula **(See formula)** where W is the group -XH or the group -CH = CH2 or -N = CH2 or the group -X-CH2-NRaRb, being Ra and Rb low molecular weight alcohol radicals that also together with the nitrogen atom can form a saturated ring, or the group -X-CH2Hal, Hal being chlorine or bromine, and where formaldehyde or a formaldehyde-supplying substance is also present in the case where W means the group -XH, and eventually in the obtained compounds it reduces a nitro group present and/or oxy groups optionally present as well as primary amino groups optionally present are acylated and eventually the obtained compounds are transformed into their salts by addition of acid. (Machine-translation by Google Translate, not legally binding)
ES421159A 1972-12-07 1973-12-05 Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding) Expired ES421159A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1044372 1972-12-07

Publications (1)

Publication Number Publication Date
ES421159A1 true ES421159A1 (en) 1976-04-16

Family

ID=3622380

Family Applications (2)

Application Number Title Priority Date Filing Date
ES421159A Expired ES421159A1 (en) 1972-12-07 1973-12-05 Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding)
ES421160A Expired ES421160A1 (en) 1972-12-07 1973-12-05 Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES421160A Expired ES421160A1 (en) 1972-12-07 1973-12-05 Procedure for the preparation of new trialcoxyaroildiamins. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
JP (1) JPS4993334A (en)
BE (1) BE808337A (en)
DD (1) DD109632A5 (en)
DE (1) DE2360545A1 (en)
ES (2) ES421159A1 (en)
FR (1) FR2209560A1 (en)
NL (1) NL7316714A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2474031A1 (en) * 1980-01-21 1981-07-24 Delalande Sa N-tri:methoxy-cinnamoyl-N'-aralkyl-piperazine derivs. - useful for treating cardiac deficiencies
FR2497512A2 (en) * 1981-01-07 1982-07-09 Delalande Sa N-tri:methoxy-cinnamoyl-N'-aralkyl-piperazine derivs. - useful for treating cardiac deficiencies
AU535498B2 (en) * 1981-05-08 1984-03-22 Otsuka Pharmaceutical Co., Ltd. Aniline derivatives, process for their preparation, and cardiotonics
DE3582371D1 (en) * 1984-07-06 1991-05-08 Otsuka Pharma Co Ltd OXINDOL COMPOUNDS, THESE COMPOSITIONS AND METHODS OF PRODUCING THE SAME.
US4623651A (en) * 1985-10-15 1986-11-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones
JP2573195B2 (en) * 1986-09-30 1997-01-22 エーザイ株式会社 Cyclic amine derivative
GB8823041D0 (en) * 1988-09-30 1988-11-09 Lilly Sa Organic compounds & their use as pharmaceuticals
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
GB8908587D0 (en) * 1989-04-15 1989-06-01 Scras Societe De Conseils De R New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
ES2071765T3 (en) * 1989-04-28 1995-07-01 Sankyo Co N-ACRYLOILPIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE AS FAP ANTAGONISTS.
US6214994B1 (en) 1997-04-21 2001-04-10 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1′-yl propanones
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones

Also Published As

Publication number Publication date
DE2360545A1 (en) 1974-06-12
NL7316714A (en) 1974-06-11
BE808337A (en) 1974-06-06
JPS4993334A (en) 1974-09-05
ES421160A1 (en) 1976-04-16
FR2209560A1 (en) 1974-07-05
DD109632A5 (en) 1974-11-12

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