ES419907A2 - Acylamido-penam-carboxylic acids and their derivatives - Google Patents

Acylamido-penam-carboxylic acids and their derivatives

Info

Publication number
ES419907A2
ES419907A2 ES419907A ES419907A ES419907A2 ES 419907 A2 ES419907 A2 ES 419907A2 ES 419907 A ES419907 A ES 419907A ES 419907 A ES419907 A ES 419907A ES 419907 A2 ES419907 A2 ES 419907A2
Authority
ES
Spain
Prior art keywords
acetamido
acylamido
phenoxyimino
methylpyrrol
thien
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419907A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of ES419907A2 publication Critical patent/ES419907A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Improvements introduced in the object of the main patent No. 402,650 applied for on May 12, 1972 by: "Procedure for the preparation of penicillin derivatives" according to which when said compounds are selected from the group consisting of 6β-acylamido-2,2 acids -dimethylpenam-3-α-carboxylic and non-toxic derivatives thereof, wherein the 6β-acylamido group is 2-phenoxyimino-2- (fur-2-yl) -acetamido; 2-phenoxyimino-2- (thien-2-yl) acetamido; 2-phenoxyimino-2-phenylacetamido; 2-cyclopentyloxyimino-2- (fur-2-yl) acetamido; 2-cyclopentyloxyimino-2- (thien-2-yl) acetamido; 2-t-butoxyimino-2- (benzo [b] furan-2-yl) acetamido; 2-methoxyimino-2- (N-methylpyrrol-2-yl) acetamido; 2-t-butoxyimino-2- (N-methylpyrrol-2-yl) acetamido; or 2- (thien-2-ylmethoxyimino) -2- (N-methylpyrrol-2-yl) acetamido, said compounds existing as isomers without or as mixtures of such isomers without and the corresponding anti isomers in which the configuration without, such improvements comprise condensing the compound of formula **(See formula)** with an acylating agent corresponding to the acid Rα.CO.OH (III) (where Rα.CO- is an acyl group as defined above) and recover the compound thus obtained of formula **(See formula)** where Rα.CO- has the meaning defined above), if desired after conversion to a non-toxic derivative thereof. (Machine-translation by Google Translate, not legally binding)
ES419907A 1972-10-25 1973-10-24 Acylamido-penam-carboxylic acids and their derivatives Expired ES419907A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4925672A GB1443950A (en) 1972-10-25 1972-10-25 Acylamido-penam-carboxylic acids and their derivatives

Publications (1)

Publication Number Publication Date
ES419907A2 true ES419907A2 (en) 1977-02-16

Family

ID=10451712

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419907A Expired ES419907A2 (en) 1972-10-25 1973-10-24 Acylamido-penam-carboxylic acids and their derivatives

Country Status (6)

Country Link
BE (1) BE806448R (en)
ES (1) ES419907A2 (en)
FR (1) FR2204404B2 (en)
GB (1) GB1443950A (en)
LU (1) LU68679A1 (en)
ZA (1) ZA738252B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009326A3 (en) * 1978-08-30 1980-04-16 Pfizer Limited Pyrrolyl keto and amino acids and derivatives thereof, processes for their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
CH579571A5 (en) * 1971-05-14 1976-09-15 Glaxo Lab Ltd

Also Published As

Publication number Publication date
BE806448R (en) 1974-04-24
ZA738252B (en) 1974-10-30
FR2204404A2 (en) 1974-05-24
FR2204404B2 (en) 1976-12-24
GB1443950A (en) 1976-07-28
AU6177873A (en) 1975-04-24
LU68679A1 (en) 1974-01-08

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170705