ES419149A1 - Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES419149A1
ES419149A1 ES419149A ES419149A ES419149A1 ES 419149 A1 ES419149 A1 ES 419149A1 ES 419149 A ES419149 A ES 419149A ES 419149 A ES419149 A ES 419149A ES 419149 A1 ES419149 A1 ES 419149A1
Authority
ES
Spain
Prior art keywords
formula
group
see formula
obtaining
penicillins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419149A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FENER S L LAB
Original Assignee
FENER S L LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FENER S L LAB filed Critical FENER S L LAB
Priority to ES419149A priority Critical patent/ES419149A1/en
Priority to NL7412848A priority patent/NL7412848A/en
Priority to JP49111320A priority patent/JPS5082087A/ja
Publication of ES419149A1 publication Critical patent/ES419149A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining α-amino-penicillins and cephalosporins, especially indicated for obtaining products of formulas I and II: **(See formula)** where: R1 is hydrogen, alkali metal or alkaline earth metal, -ammonium or substituted ammonium, or a group chosen from: 2,2,2-trichlorethyl, phenacyl, p-bromo-phenacyl, benzyl, p-nitrobenzyl, 2,4-dinitro- benzyl and C2-C6 acyloxymethyl R2 is a hydrogen atom, R3 represents phenyl, 1,4-cyclohexadien-1-yl, 1-thienyl, 2-thienyl, and A represents a hydrogen atom or an acetoxy group, characterized by the reaction of an inert solvent and at a temperature between -25ºC and + 45ºC of a salt of formula III: **(See formula)** where: R2 and R3 have the aforementioned meaning, M represents an alkali, alkaline-earth metal, ammonia or substituted ammonium, Z represents a group consisting of: carbobenzyloxy, p-nitro-carbobenzyloxy, t.butoxy-carbonyl, 2, 2,2-trichloroethoxycarbonyl or a group -C (CH3) = CH-COOR4 (in which R4 is a methyl or ethyl); with triazine trichloride or triazine tribromide, then treating the resulting condensation product with a solution of the aminated compound of formula IV: **(See formula)** where X represents one of the following groups: **(See formula)** wherein R1 has the meaning indicated above, to obtain an N-protected aminopenicillin or cephalosporin of formula V: **(See formula)** where R2, R3 Z and X have the same meaning as indicated above, and as a final step, remove the protecting group or groups to obtain the final product of formulas I and II. (Machine-translation by Google Translate, not legally binding)
ES419149A 1973-09-28 1973-09-28 Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding) Expired ES419149A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES419149A ES419149A1 (en) 1973-09-28 1973-09-28 Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding)
NL7412848A NL7412848A (en) 1973-09-28 1974-09-27 Alpha-aminopenicillin and cephalosporin prepn - by acylating 7-amino (desacetoxy)cephalosporanic or 6-aminopenicillanic acid
JP49111320A JPS5082087A (en) 1973-09-28 1974-09-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES419149A ES419149A1 (en) 1973-09-28 1973-09-28 Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES419149A1 true ES419149A1 (en) 1976-07-01

Family

ID=8465098

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419149A Expired ES419149A1 (en) 1973-09-28 1973-09-28 Procedure for the obtaining of a-amino-penicillins and cephalosporins. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
JP (1) JPS5082087A (en)
ES (1) ES419149A1 (en)
NL (1) NL7412848A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1126544B (en) * 1979-12-07 1986-05-21 Dobfar Spa PROCEDURE FOR THE PREPARATION OF 7-AMINO-DESACETOXY CEPHALOSPORANIC ACID DERIVATIVES
CN1269776C (en) * 1999-03-08 2006-08-16 株式会社德山 Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt

Also Published As

Publication number Publication date
NL7412848A (en) 1975-04-02
JPS5082087A (en) 1975-07-03

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