ES417763A1 - Process and apparatus for counting biological particles - Google Patents

Process and apparatus for counting biological particles

Info

Publication number
ES417763A1
ES417763A1 ES417763A ES417763A ES417763A1 ES 417763 A1 ES417763 A1 ES 417763A1 ES 417763 A ES417763 A ES 417763A ES 417763 A ES417763 A ES 417763A ES 417763 A1 ES417763 A1 ES 417763A1
Authority
ES
Spain
Prior art keywords
blood cells
light
particles
light beam
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES417763A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MERIC
Original Assignee
MERIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MERIC filed Critical MERIC
Publication of ES417763A1 publication Critical patent/ES417763A1/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M11/00—Counting of objects distributed at random, e.g. on a surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G01N2021/4716—Using a ring of sensors, or a combination of diaphragm and sensors; Annular sensor

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Procedure and apparatus for the instantaneous counting of all the figurative elements of the blood by application of the known methods of diffraction of a light beam by suspended blood particles and measurement of the flow diffused by photosensitive cells, the procedure being characterized by two blood samples susceptible to analysis, in one of which the red blood cells have been hemolyzed while in the other these blood cells have been spherized, are placed in the path of a light beam from a convergent optical system powered by a coherent and monochromatic light source to obtain in the focal plane of the optical system at least two photosensitive zones that receive the light fluxes diffracted by the particles, said fluxes corresponding to directions that form angles respectively with the initial direction of the light beam, between: **(See formula)** where λ the wavelength of the light used, dm the average diameter of the particles susceptible to analysis; s1, S2, s'1, S'2 being expressed in radians; the light received by these zones is transformed into electrical signals, while attached electrical means, of a type known per se, allow the results of analyzes relating to the number of platelets and white blood cells as well as the number of red blood cells, hematocritis and average globular volume. (Machine-translation by Google Translate, not legally binding)
ES417763A 1972-08-10 1973-08-10 Process and apparatus for counting biological particles Expired ES417763A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7228858A FR2195907A5 (en) 1972-08-10 1972-08-10

Publications (1)

Publication Number Publication Date
ES417763A1 true ES417763A1 (en) 1976-02-16

Family

ID=9103117

Family Applications (1)

Application Number Title Priority Date Filing Date
ES417763A Expired ES417763A1 (en) 1972-08-10 1973-08-10 Process and apparatus for counting biological particles

Country Status (9)

Country Link
US (1) US3830569A (en)
JP (1) JPS49125097A (en)
BE (1) BE803075A (en)
DE (1) DE2340252A1 (en)
ES (1) ES417763A1 (en)
FR (1) FR2195907A5 (en)
GB (1) GB1400640A (en)
IT (1) IT1008026B (en)
NL (1) NL7310960A (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2409273A1 (en) * 1974-02-27 1975-09-04 Behringwerke Ag METHOD AND DEVICE FOR MEASURING ANTIGEN-ANTIBODY REACTIONS
US3930726A (en) * 1974-05-29 1976-01-06 Reginald C. Shuck System for measuring volumetric ratios of liquid suspended solids
US3923397A (en) * 1974-05-29 1975-12-02 Dolive Stephen E Hematocrit measuring method
US4052600A (en) * 1975-01-06 1977-10-04 Leeds & Northrup Company Measurement of statistical parameters of a distribution of suspended particles
US4139303A (en) * 1977-01-21 1979-02-13 The Board Of Regents Of The University Of Washington Adaptive coherent optical processing method and apparatus for recognizing and counting objects
US4303336A (en) * 1978-08-28 1981-12-01 Baxter Travenol Laboratories, Inc. Method and apparatus for making a rapid measurement of the hematocrit of blood
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
DE2964764D1 (en) * 1978-12-28 1983-03-17 Omnium Assainissement Method of measuring the volume of suspended matter in a liquid with special application to the automatic determination of the quality of water
FR2445523A1 (en) * 1978-12-28 1980-07-25 Sable Sarl Testing clarity of water by evaluating suspended tiny particles - which diffract laser beam to give flux measured by photoelectric cells
US4274741A (en) * 1979-09-26 1981-06-23 Compagnie Industrielle Des Lasers Device for determining the granulometric composition of a mixture of particles by diffraction of light
US4412004A (en) * 1981-06-26 1983-10-25 Technicon Instruments Corporation Method for treating red blood cells to effect sphering and reagent therefor
FR2521294A1 (en) * 1982-02-05 1983-08-12 Bajard Jean GLOBAL INTERFERENTIAL GRANULOMETRY METHOD APPLICABLE IN PARTICULAR TO POLYDISPERSE BIOLOGICAL PARTICLES
US4441816A (en) * 1982-03-25 1984-04-10 The United States Of America As Represented By The United States Department Of Energy Optical double-slit particle measuring system
US4522494A (en) * 1982-07-07 1985-06-11 The United States Of America As Represented By The Department Of Health And Human Services Non-invasive optical assessment of platelet viability
DE3575470D1 (en) * 1985-06-07 1990-02-22 Fritsch Gmbh DEVICE FOR DETERMINING GRAIN SIZES.
JPS63215942A (en) * 1987-03-04 1988-09-08 Natl Aerospace Lab Photoelectric conversion sensor for measuring particle size distribution
KR970007077B1 (en) * 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 Multi-part diefferential analyzing apparatus using light scatter techniques
US5331958A (en) * 1992-03-31 1994-07-26 University Of Manitoba Spectrophotometric blood analysis
JP3375203B2 (en) * 1994-08-08 2003-02-10 シスメックス株式会社 Cell analyzer
US5601080A (en) * 1994-12-28 1997-02-11 Coretech Medical Technologies Corporation Spectrophotometric blood analysis
JP3285309B2 (en) * 1996-03-26 2002-05-27 株式会社堀場製作所 Photo detector
US5872627A (en) * 1996-07-30 1999-02-16 Bayer Corporation Method and apparatus for detecting scattered light in an analytical instrument
US5844685A (en) * 1996-07-30 1998-12-01 Bayer Corporation Reference laser beam sampling apparatus
US6041246A (en) 1997-10-14 2000-03-21 Transonic Systems, Inc. Single light sensor optical probe for monitoring blood parameters and cardiovascular measurements
US6718190B2 (en) * 1997-10-14 2004-04-06 Transonic Systems, Inc. Sensor calibration and blood volume determination
US8071051B2 (en) * 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US9280726B2 (en) 2009-12-18 2016-03-08 Fpinnovation On-line macrocontaminant analyser and method
JP5533055B2 (en) 2010-03-10 2014-06-25 ソニー株式会社 Optical measuring apparatus and optical measuring method
WO2014144585A1 (en) * 2013-03-15 2014-09-18 Beckman Coulter, Inc. Radiated light filtering for a flow cytometer
CN103487362B (en) * 2013-10-16 2015-09-23 中国工程物理研究院激光聚变研究中心 A kind of laser particle measurement probe
CN107941662B (en) * 2017-11-10 2020-01-21 吉林大学 Device and method for detecting distribution of particles in flame by using intense field laser
CN110542686A (en) * 2019-09-30 2019-12-06 广东牧玛生命科技有限公司 Multifunctional analysis instrument
WO2021099081A1 (en) * 2019-11-22 2021-05-27 Ams Ag Optical based particulate matter sensing

Also Published As

Publication number Publication date
FR2195907A5 (en) 1974-03-08
BE803075A (en) 1973-11-16
JPS49125097A (en) 1974-11-29
DE2340252A1 (en) 1974-02-21
IT1008026B (en) 1976-11-10
GB1400640A (en) 1975-07-16
US3830569A (en) 1974-08-20
NL7310960A (en) 1974-02-12

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