ES416998A1 - Un procedimiento de preparacion de derivados de 13-cis- prostaglandinas. - Google Patents
Un procedimiento de preparacion de derivados de 13-cis- prostaglandinas.Info
- Publication number
- ES416998A1 ES416998A1 ES416998A ES416998A ES416998A1 ES 416998 A1 ES416998 A1 ES 416998A1 ES 416998 A ES416998 A ES 416998A ES 416998 A ES416998 A ES 416998A ES 416998 A1 ES416998 A1 ES 416998A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- cis
- ether
- see
- labile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 8
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002603 chloroethyl group Chemical group [H]C([*])([H])C([H])([H])Cl 0.000 abstract 1
- 125000006003 dichloroethyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US272880A US3867377A (en) | 1972-07-18 | 1972-07-18 | Method of making 13-cis prostaglandin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES416998A1 true ES416998A1 (es) | 1976-06-16 |
Family
ID=23041674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES416998A Expired ES416998A1 (es) | 1972-07-18 | 1973-07-17 | Un procedimiento de preparacion de derivados de 13-cis- prostaglandinas. |
Country Status (13)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110368A (en) * | 1972-07-24 | 1978-08-29 | American Cyanamid Company | Hydro substituted prostanoic acids and esters |
| US3998852A (en) * | 1973-04-16 | 1976-12-21 | Syntex (U.S.A.) Inc. | Novel prostaglandin intermediates and process for the production thereof |
| US4055564A (en) * | 1975-01-15 | 1977-10-25 | Syntex (U.S.A.) Inc. | Novel prostaglandin intermediates and process for the production thereof |
| US4026909A (en) * | 1975-07-14 | 1977-05-31 | The Upjohn Company | Cis-13-PGF2.sub.α analogs |
| FR2353287A1 (fr) * | 1975-08-29 | 1977-12-30 | Roussel Uclaf | Nouveaux derives du cyclopentanol, leur procede de preparation et leur application comme medicaments |
-
1972
- 1972-07-18 US US272880A patent/US3867377A/en not_active Expired - Lifetime
-
1973
- 1973-05-29 CA CA172,898A patent/CA1038378A/en not_active Expired
- 1973-06-01 IL IL42425A patent/IL42425A/en unknown
- 1973-06-12 GB GB2799873A patent/GB1430995A/en not_active Expired
- 1973-06-14 AU AU56904/73A patent/AU474934B2/en not_active Expired
- 1973-07-09 DE DE2357571*A patent/DE2357571A1/de active Pending
- 1973-07-09 DE DE19732334764 patent/DE2334764A1/de active Pending
- 1973-07-13 FR FR7325794A patent/FR2192830B1/fr not_active Expired
- 1973-07-16 BE BE133513A patent/BE802385A/xx unknown
- 1973-07-16 BE BE133514A patent/BE802386A/xx unknown
- 1973-07-17 JP JP48082451A patent/JPS4992027A/ja active Pending
- 1973-07-17 ES ES416998A patent/ES416998A1/es not_active Expired
- 1973-07-18 CH CH1052673A patent/CH592620A5/xx not_active IP Right Cessation
- 1973-07-18 NL NL7310007A patent/NL7310007A/xx not_active Application Discontinuation
- 1973-07-18 AT AT632673A patent/AT341688B/de not_active IP Right Cessation
-
1975
- 1975-04-25 FR FR7513144A patent/FR2283118A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2192830A1 (US06589383-20030708-C00041.png) | 1974-02-15 |
| AT341688B (de) | 1978-02-27 |
| AU474934B2 (en) | 1976-08-05 |
| BE802385A (fr) | 1974-01-16 |
| ATA632673A (de) | 1977-06-15 |
| GB1430995A (en) | 1976-04-07 |
| CH592620A5 (US06589383-20030708-C00041.png) | 1977-10-31 |
| JPS4992027A (US06589383-20030708-C00041.png) | 1974-09-03 |
| DE2357571A1 (de) | 1974-10-03 |
| US3867377A (en) | 1975-02-18 |
| FR2283118A1 (fr) | 1976-03-26 |
| DE2334764A1 (de) | 1974-02-14 |
| IL42425A (en) | 1976-09-30 |
| CA1038378A (en) | 1978-09-12 |
| NL7310007A (US06589383-20030708-C00041.png) | 1974-01-22 |
| FR2192830B1 (US06589383-20030708-C00041.png) | 1977-07-01 |
| BE802386A (fr) | 1974-01-16 |
| AU5690473A (en) | 1974-12-19 |
| FR2283118B1 (US06589383-20030708-C00041.png) | 1979-07-27 |
| IL42425A0 (en) | 1973-08-29 |
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