ES416907A1 - A method for producing cephalosporine preparations for employment via rectal. (Machine-translation by Google Translate, not legally binding) - Google Patents
A method for producing cephalosporine preparations for employment via rectal. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES416907A1 ES416907A1 ES416907A ES416907A ES416907A1 ES 416907 A1 ES416907 A1 ES 416907A1 ES 416907 A ES416907 A ES 416907A ES 416907 A ES416907 A ES 416907A ES 416907 A1 ES416907 A1 ES 416907A1
- Authority
- ES
- Spain
- Prior art keywords
- see formula
- powder
- polyoxyethylene
- translation
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A method of producing cephalosporin preparations for rectal use comprising spraying powder of a cephalosporin compound of the formula **(See formula)** where R1 represents **(See formula)** R2 represents (see formula), and when R2 is (see formula), M represents a negative ion and when R2 is different from (see formula) M represents an alkali metal, to obtain a fine powder whose particle size is less than 200 microns in diameter, dry the powder of the cephalosporin compound so that the water content in the powder, and mix the finely powdered and dried powder of the cephalosporin compound (I) with an ointment or suppository base in an amount of 0.5 to 15 times by weight relative to the cephalosporin compound (I) and at least one surfactant nonionic selected from the group consisting of a polyoxyethylene-higher alcohol-ether, a polyoxyethylene-alcohol-aryl-ether and a polyoxyethylene-fatty acid ester in an amount of 0.005 to 0.5 times by weight in relation to said base, which Lipophilic Hydrophilic Balance Index (EHL) is within the range of 7 to 17. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7116372A JPS4930519A (en) | 1972-07-14 | 1972-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES416907A1 true ES416907A1 (en) | 1976-03-16 |
Family
ID=13452681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES416907A Expired ES416907A1 (en) | 1972-07-14 | 1973-07-13 | A method for producing cephalosporine preparations for employment via rectal. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS4930519A (en) |
ES (1) | ES416907A1 (en) |
FR (1) | FR2275214A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5336520B2 (en) * | 1972-03-16 | 1978-10-03 | ||
JPS53107408A (en) * | 1977-02-28 | 1978-09-19 | Yamanouchi Pharmaceut Co Ltd | Micellar preparation for rectal infusion |
JPS55119771U (en) * | 1979-01-23 | 1980-08-25 | ||
JPS56104813A (en) * | 1980-01-25 | 1981-08-20 | Takeda Chem Ind Ltd | Composition for rectal infusion containing compound having beta-lactam ring |
EP0091502A1 (en) * | 1982-04-13 | 1983-10-19 | Asahi Kasei Kogyo Kabushiki Kaisha | A pharmaceutical preparation of cephalosporin for rectal administration |
-
1972
- 1972-07-14 JP JP7116372A patent/JPS4930519A/ja active Pending
-
1973
- 1973-07-12 FR FR7325666A patent/FR2275214A1/en active Granted
- 1973-07-13 ES ES416907A patent/ES416907A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2275214B1 (en) | 1978-07-28 |
JPS4930519A (en) | 1974-03-19 |
FR2275214A1 (en) | 1976-01-16 |
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