ES415421A1 - Digitoxin esters - Google Patents
Digitoxin estersInfo
- Publication number
- ES415421A1 ES415421A1 ES415421A ES415421A ES415421A1 ES 415421 A1 ES415421 A1 ES 415421A1 ES 415421 A ES415421 A ES 415421A ES 415421 A ES415421 A ES 415421A ES 415421 A1 ES415421 A1 ES 415421A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- para
- general formula
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Procedure for the preparation of new cardioglycosides of the general formula I **(See formula)** where R1 can mean the group **(See formula)** and R2 can mean a preferably straight chain alcohol radical with 2 to 15 carbon atoms, an alcohol radical with 1 to 4 carbon atoms [preferably in terminal position] substituted by a halogen atom, a nitrile group, a carboethoxy group or an optionally substituted phenyl or phenoxy radical [especially a para-tolyl or para-toloxy radical, a para-methoxyphenyl or para-methoxyphenoxy radical or a para-chlorophenyl or para-chlorophenoxy radical] or a cycloalkyl or cycloalkylmethyl radical with 3 to 6 atoms in the ring or an N-trifluoromethylcarbonylaminoethyl radical, characterized in that a compound of the general formula II **(See formula)** where R1 has the meanings mentioned above, it is subjected to a transesterification reaction with an orthoester of the general formula III wherein R2 has the meanings mentioned above and R means a lower alcohol group, to transform it into a cyclic orthoester of the general formula IV **(See formula)** where R, R1 and R2 have the meanings indicated above, the transesterification reaction being carried out in the presence of acid catalysts, optionally with the addition of an inert solvent to the reaction mixture, and at a temperature comprised between 0ºC and the reflux temperature of the reaction mixture, preferably at around room temperature, and because said orthoester of formula IV is partially saponified in the presence of an aqueous acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19722226398 DE2226398A1 (en) | 1972-05-31 | 1972-05-31 | NEW HEART GLYCOSIDES AND METHODS FOR THEIR PRODUCTION |
Publications (1)
Publication Number | Publication Date |
---|---|
ES415421A1 true ES415421A1 (en) | 1976-06-01 |
Family
ID=5846376
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES415421A Expired ES415421A1 (en) | 1972-05-31 | 1973-05-30 | Digitoxin esters |
ES0423500A Expired ES423500A1 (en) | 1972-05-31 | 1974-02-22 | Procedure for the preparation of new cardioglycosides. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0423500A Expired ES423500A1 (en) | 1972-05-31 | 1974-02-22 | Procedure for the preparation of new cardioglycosides. (Machine-translation by Google Translate, not legally binding) |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS4961155A (en) |
AT (1) | AT328093B (en) |
BE (1) | BE800343A (en) |
CH (1) | CH577528A5 (en) |
DE (1) | DE2226398A1 (en) |
DK (1) | DK132832C (en) |
ES (2) | ES415421A1 (en) |
FI (1) | FI52348C (en) |
FR (1) | FR2186264B1 (en) |
GB (1) | GB1428041A (en) |
NL (1) | NL7307540A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325014B1 (en) * | 2000-09-22 | 2012-05-23 | JPI Commercial, LLC | Gamma-hydroxybutyrate compositions containing carbohydrate carriers |
WO2023092188A1 (en) * | 2021-11-26 | 2023-06-01 | DemAgtech Pty Ltd | "compounds and methods" |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1259954A (en) * | 1953-06-05 | 1961-05-05 | Sandoz Ag | Process for preparing acetyl digitoxin-alpha |
FR1479268A (en) * | 1964-12-19 | 1967-05-05 | Kutnowskie Zakl Farma | Process for the production of alpha-acetyldigitoxyin |
RO60624A (en) * | 1970-03-05 | 1976-07-15 |
-
1972
- 1972-05-31 DE DE19722226398 patent/DE2226398A1/en active Pending
-
1973
- 1973-05-21 AT AT439873A patent/AT328093B/en not_active IP Right Cessation
- 1973-05-28 CH CH765473A patent/CH577528A5/xx not_active IP Right Cessation
- 1973-05-30 DK DK300273A patent/DK132832C/en active
- 1973-05-30 NL NL7307540A patent/NL7307540A/xx unknown
- 1973-05-30 JP JP6076073A patent/JPS4961155A/ja active Pending
- 1973-05-30 ES ES415421A patent/ES415421A1/en not_active Expired
- 1973-05-30 BE BE131787A patent/BE800343A/en unknown
- 1973-05-30 FR FR7319898A patent/FR2186264B1/fr not_active Expired
- 1973-05-30 FI FI174773A patent/FI52348C/en active
- 1973-05-30 GB GB2585273A patent/GB1428041A/en not_active Expired
-
1974
- 1974-02-22 ES ES0423500A patent/ES423500A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1428041A (en) | 1976-03-17 |
ATA439873A (en) | 1975-05-15 |
JPS4961155A (en) | 1974-06-13 |
BE800343A (en) | 1973-11-30 |
ES423500A1 (en) | 1976-11-16 |
DE2226398A1 (en) | 1973-12-13 |
AT328093B (en) | 1976-03-10 |
FI52348B (en) | 1977-05-02 |
DK132832C (en) | 1976-07-19 |
NL7307540A (en) | 1973-12-04 |
AU5631673A (en) | 1974-12-05 |
FR2186264B1 (en) | 1976-07-02 |
FR2186264A1 (en) | 1974-01-11 |
CH577528A5 (en) | 1976-07-15 |
DK132832B (en) | 1976-02-16 |
FI52348C (en) | 1977-08-10 |
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