ES415421A1 - Digitoxin esters - Google Patents

Digitoxin esters

Info

Publication number
ES415421A1
ES415421A1 ES415421A ES415421A ES415421A1 ES 415421 A1 ES415421 A1 ES 415421A1 ES 415421 A ES415421 A ES 415421A ES 415421 A ES415421 A ES 415421A ES 415421 A1 ES415421 A1 ES 415421A1
Authority
ES
Spain
Prior art keywords
radical
para
general formula
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES415421A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES415421A1 publication Critical patent/ES415421A1/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Procedure for the preparation of new cardioglycosides of the general formula I **(See formula)** where R1 can mean the group **(See formula)** and R2 can mean a preferably straight chain alcohol radical with 2 to 15 carbon atoms, an alcohol radical with 1 to 4 carbon atoms [preferably in terminal position] substituted by a halogen atom, a nitrile group, a carboethoxy group or an optionally substituted phenyl or phenoxy radical [especially a para-tolyl or para-toloxy radical, a para-methoxyphenyl or para-methoxyphenoxy radical or a para-chlorophenyl or para-chlorophenoxy radical] or a cycloalkyl or cycloalkylmethyl radical with 3 to 6 atoms in the ring or an N-trifluoromethylcarbonylaminoethyl radical, characterized in that a compound of the general formula II **(See formula)** where R1 has the meanings mentioned above, it is subjected to a transesterification reaction with an orthoester of the general formula III wherein R2 has the meanings mentioned above and R means a lower alcohol group, to transform it into a cyclic orthoester of the general formula IV **(See formula)** where R, R1 and R2 have the meanings indicated above, the transesterification reaction being carried out in the presence of acid catalysts, optionally with the addition of an inert solvent to the reaction mixture, and at a temperature comprised between 0ºC and the reflux temperature of the reaction mixture, preferably at around room temperature, and because said orthoester of formula IV is partially saponified in the presence of an aqueous acid. (Machine-translation by Google Translate, not legally binding)
ES415421A 1972-05-31 1973-05-30 Digitoxin esters Expired ES415421A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722226398 DE2226398A1 (en) 1972-05-31 1972-05-31 NEW HEART GLYCOSIDES AND METHODS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ES415421A1 true ES415421A1 (en) 1976-06-01

Family

ID=5846376

Family Applications (2)

Application Number Title Priority Date Filing Date
ES415421A Expired ES415421A1 (en) 1972-05-31 1973-05-30 Digitoxin esters
ES0423500A Expired ES423500A1 (en) 1972-05-31 1974-02-22 Procedure for the preparation of new cardioglycosides. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES0423500A Expired ES423500A1 (en) 1972-05-31 1974-02-22 Procedure for the preparation of new cardioglycosides. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS4961155A (en)
AT (1) AT328093B (en)
BE (1) BE800343A (en)
CH (1) CH577528A5 (en)
DE (1) DE2226398A1 (en)
DK (1) DK132832C (en)
ES (2) ES415421A1 (en)
FI (1) FI52348C (en)
FR (1) FR2186264B1 (en)
GB (1) GB1428041A (en)
NL (1) NL7307540A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1325014B1 (en) * 2000-09-22 2012-05-23 JPI Commercial, LLC Gamma-hydroxybutyrate compositions containing carbohydrate carriers
WO2023092188A1 (en) * 2021-11-26 2023-06-01 DemAgtech Pty Ltd "compounds and methods"

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1259954A (en) * 1953-06-05 1961-05-05 Sandoz Ag Process for preparing acetyl digitoxin-alpha
FR1479268A (en) * 1964-12-19 1967-05-05 Kutnowskie Zakl Farma Process for the production of alpha-acetyldigitoxyin
RO60624A (en) * 1970-03-05 1976-07-15

Also Published As

Publication number Publication date
GB1428041A (en) 1976-03-17
ATA439873A (en) 1975-05-15
JPS4961155A (en) 1974-06-13
BE800343A (en) 1973-11-30
ES423500A1 (en) 1976-11-16
DE2226398A1 (en) 1973-12-13
AT328093B (en) 1976-03-10
FI52348B (en) 1977-05-02
DK132832C (en) 1976-07-19
NL7307540A (en) 1973-12-04
AU5631673A (en) 1974-12-05
FR2186264B1 (en) 1976-07-02
FR2186264A1 (en) 1974-01-11
CH577528A5 (en) 1976-07-15
DK132832B (en) 1976-02-16
FI52348C (en) 1977-08-10

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