ES414547A1 - A procedure for the preparation of a derivative of ampicillin. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of a derivative of ampicillin. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES414547A1 ES414547A1 ES414547A ES414547A ES414547A1 ES 414547 A1 ES414547 A1 ES 414547A1 ES 414547 A ES414547 A ES 414547A ES 414547 A ES414547 A ES 414547A ES 414547 A1 ES414547 A1 ES 414547A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- see formula
- hydrogen atom
- formula
- ampicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
A procedure for the preparation of an ampicillin derivative represented by the general formula **(See formula)** where R represents **(See formula)** where R1 represents a hydrogen atom, a methyl group or an ethyl group and A and B each represent a hydrogen atom, a hydroxy group, a methyl group, a methoxy group, a nitro group or a halogen atom, B can be combined with A on the carbon atom of position 3 to form a group **(See formula)** where Z represents -CH = N- or -CH = CH- and R2 represents a hydrogen atom, a hydroxy group, a phenyl group, a methyl group, a benzyl group, a methoxy group, an ethoxy group, a methylthio group, a trifluoromethyl group, a halogen atom, a nitro group, an acetyl group, an acetamido group, an ethoxycarbonyloxy group or a methylsulfonyl group, R2 can also form together with the group **(See formula)** a fused thiazolo, isothiazolo, pyrrolo, furo or benzo ring, which may be substituted with an oxo group, a methyl group or an acetyl group) and the dotted lines mean an arbitrary double bond, **(See formula)** where R3 and R4 each represent a hydrogen atom or a methyl group, **(See formula)** R5 represents a halogen atom, a methoxy group, a nitro group or a hydroxy group and R6 represents a hydrogen atom, a methoxy group, a halogen atom, a nitro group or a hydroxy group, or **(See formula)** where R7 represents a hydrogen atom or a hydroxy group, Y represents oxygen or sulfur and the dotted line means an arbitrary double bond, said substituent group being attached to the ampicillin molecule through a group -CO- in the positions 2, 3, 5 or 6 when the group = 0 is in position 4 and being attached to the ampicillin molecule through a group -CO- in positions 2, 4 or 5 when the group = 0 is in position 6; and you leave them; whose procedure consists in reacting the 6-aminopenicilanic acid derivatives represented by the formula **(See formula)** where D represents a hydrogen atom or **(See formula)** E represents a hydrogen atom or a group capable of being released under mild conditions, with a carboxylic acid represented by the formula **(See formula)** where R8 represents **(See formula)** when D is a hydrogen atom or R8 represents R when D is **(See formula)** or reactive derivatives thereof and releasing group E when said group is capable of being released under mild conditions. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4511872A JPS5547036B2 (en) | 1972-05-08 | 1972-05-08 | |
| JP8342472A JPS4941396A (en) | 1972-08-21 | 1972-08-21 | |
| JP8510272A JPS4942692A (en) | 1972-08-25 | 1972-08-25 | |
| JP8510372A JPS4942693A (en) | 1972-08-25 | 1972-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414547A1 true ES414547A1 (en) | 1977-01-16 |
Family
ID=27461645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414547A Expired ES414547A1 (en) | 1972-05-08 | 1973-05-08 | A procedure for the preparation of a derivative of ampicillin. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES414547A1 (en) |
-
1973
- 1973-05-08 ES ES414547A patent/ES414547A1/en not_active Expired
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