ES412584A1 - Procedure for preparation of (alcohil-4-piperidil-4) - oxialcanols. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of (alcohil-4-piperidil-4) - oxialcanols. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES412584A1
ES412584A1 ES412584A ES412584A ES412584A1 ES 412584 A1 ES412584 A1 ES 412584A1 ES 412584 A ES412584 A ES 412584A ES 412584 A ES412584 A ES 412584A ES 412584 A1 ES412584 A1 ES 412584A1
Authority
ES
Spain
Prior art keywords
formula
product
radical
translation
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412584A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES412584A1 publication Critical patent/ES412584A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation procedure for (alcohol-4-piperidyl-4) -oxy-alkanols of formula 1: **(See formula)** where R represents a hydrogen atom or an alcohol radical containing a maximum of 4 carbon atoms, Z represents a linear or branched alcohol radical containing a maximum of 10 carbon atoms, n may take the values 0, 1 or 2, and A represents a hydrogen atom or a radical -CO-R1 in which R1 represents a polymethoxyphenyl radical or an alcohol radical containing a maximum of 18 carbon atoms and which can carry a double bond or an oxy radical (-0-), characterized in that a cyclic acetyl of benzylpiperidone of formula 2 is reacted in anhydrous medium: **(See formula)** in which R and n have the aforementioned meaning, with an organ-magnesium of formula 3: Z-Mg-Hal (3) in which Hal represents a chlorine, bromine or iodine atom and Z has the previously indicated meaning, the product of formula 4 is made to act: **(See formula)** resulting either hydrogen in the presence of a palladium-based catalyst to obtain a product of formula 1 in which A represents a hydrogen atom, or an acid chloride of formula Cl-CO-R1 in which R1 has the meaning indicated above, to obtain a product of formula 5: **(See formula)** wherein R, R1, Z and n have the aforementioned meaning and said product of formula 5 is actuated, hydrogen in the presence of a palladium-based catalyst to obtain a product of formula 1, in which A represents a radical -CO-R1. (Machine-translation by Google Translate, not legally binding)
ES412584A 1972-03-14 1973-03-13 Procedure for preparation of (alcohil-4-piperidil-4) - oxialcanols. (Machine-translation by Google Translate, not legally binding) Expired ES412584A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7208801A FR2175564A1 (en) 1972-03-14 1972-03-14 2(4-alkyl-4-piperidyloxy)alkanols - inters for human and veterinary drugs

Publications (1)

Publication Number Publication Date
ES412584A1 true ES412584A1 (en) 1976-01-16

Family

ID=9095159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412584A Expired ES412584A1 (en) 1972-03-14 1973-03-13 Procedure for preparation of (alcohil-4-piperidil-4) - oxialcanols. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES412584A1 (en)
FR (1) FR2175564A1 (en)

Also Published As

Publication number Publication date
FR2175564B1 (en) 1975-04-25
FR2175564A1 (en) 1973-10-26

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