ES408969A1 - Un procedimiento de preparacion de compuestos de cefalospo-rina. - Google Patents
Un procedimiento de preparacion de compuestos de cefalospo-rina.Info
- Publication number
- ES408969A1 ES408969A1 ES408969A ES408969A ES408969A1 ES 408969 A1 ES408969 A1 ES 408969A1 ES 408969 A ES408969 A ES 408969A ES 408969 A ES408969 A ES 408969A ES 408969 A1 ES408969 A1 ES 408969A1
- Authority
- ES
- Spain
- Prior art keywords
- followed
- hydrogen
- carbamoyloxy
- sodium
- potassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 cephalosporin compounds Chemical class 0.000 title abstract 10
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000007257 deesterification reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 2
- 239000011591 potassium Chemical group 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- OVEZDLPQESFQDI-UHFFFAOYSA-O O-pyridin-1-ium-1-yl carbamothioate Chemical compound C(N)(=S)O[N+]1=CC=CC=C1 OVEZDLPQESFQDI-UHFFFAOYSA-O 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000006198 methoxylation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- PFZCOWLKXHIVII-UHFFFAOYSA-N pyridin-1-ium-1-amine Chemical compound N[N+]1=CC=CC=C1 PFZCOWLKXHIVII-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20305171A | 1971-11-29 | 1971-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES408969A1 true ES408969A1 (es) | 1975-10-01 |
Family
ID=22752269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES408969A Expired ES408969A1 (es) | 1971-11-29 | 1972-11-24 | Un procedimiento de preparacion de compuestos de cefalospo-rina. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3780033A (forum.php) |
| JP (1) | JPS4862789A (forum.php) |
| CA (1) | CA982553A (forum.php) |
| CH (1) | CH594689A5 (forum.php) |
| DD (1) | DD100957A5 (forum.php) |
| ES (1) | ES408969A1 (forum.php) |
| NL (1) | NL7215463A (forum.php) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155905A (en) * | 1971-01-22 | 1979-05-22 | E. R. Squibb & Sons, Inc. | 6-Substituted penicillanic acid and derivatives thereof |
| GB1366682A (en) * | 1971-04-30 | 1974-09-11 | Merck & Co Inc | Process to prepare antibiotic intermediates |
| US3989697A (en) * | 1973-05-02 | 1976-11-02 | E. R. Squibb & Sons, Inc. | 7-Methoxy phenylureidocephalosporins |
| US4029654A (en) * | 1973-05-02 | 1977-06-14 | E. R. Squibb & Sons, Inc. | 7-Methoxy phenylureidocephalosporins |
| US3974151A (en) * | 1973-06-05 | 1976-08-10 | Merck & Co., Inc. | Cephalosporin compounds |
| US4061852A (en) * | 1973-08-23 | 1977-12-06 | E. R. Squibb & Sons, Inc. | 7-Methoxy furylureidocephalosporins |
| US4029653A (en) * | 1973-08-23 | 1977-06-14 | E. R. Squibb & Sons, Inc. | 7-Methoxy 7-alpha-ureidothienylacetamidocephalosporins |
| US3978051A (en) * | 1973-08-23 | 1976-08-31 | E. R. Squibb & Sons, Inc. | 7-Methoxy 7-α-ureidothienylacetamidocephalosporins |
| US4028354A (en) * | 1976-03-08 | 1977-06-07 | E. R. Squibb & Sons, Inc. | Alkenyl and alkinylureido cephalosporins |
| US4063019A (en) | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
| JP2648862B2 (ja) * | 1987-08-10 | 1997-09-03 | 塩野義製薬株式会社 | 置換オキシカルボニルアミノセフェム化合物の製法 |
-
1971
- 1971-11-29 US US00203051A patent/US3780033A/en not_active Expired - Lifetime
-
1972
- 1972-11-15 NL NL7215463A patent/NL7215463A/xx not_active Application Discontinuation
- 1972-11-23 CH CH1706272A patent/CH594689A5/xx not_active IP Right Cessation
- 1972-11-24 ES ES408969A patent/ES408969A1/es not_active Expired
- 1972-11-24 DD DD167077A patent/DD100957A5/xx unknown
- 1972-11-27 CA CA157,676A patent/CA982553A/en not_active Expired
- 1972-11-29 JP JP47119076A patent/JPS4862789A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DD100957A5 (forum.php) | 1973-10-12 |
| US3780033A (en) | 1973-12-18 |
| JPS4862789A (forum.php) | 1973-09-01 |
| NL7215463A (forum.php) | 1973-06-01 |
| CA982553A (en) | 1976-01-27 |
| CH594689A5 (forum.php) | 1978-01-31 |
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