ES396293A1 - Preparation of 1-alkyl-2-aminomethyl-pyrrolidines - Google Patents

Preparation of 1-alkyl-2-aminomethyl-pyrrolidines

Info

Publication number
ES396293A1
ES396293A1 ES396293A ES396293A ES396293A1 ES 396293 A1 ES396293 A1 ES 396293A1 ES 396293 A ES396293 A ES 396293A ES 396293 A ES396293 A ES 396293A ES 396293 A1 ES396293 A1 ES 396293A1
Authority
ES
Spain
Prior art keywords
alkyl
aminomethyl
preparation
pyrrolidines
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES396293A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fratmann SA
Original Assignee
Fratmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fratmann SA filed Critical Fratmann SA
Publication of ES396293A1 publication Critical patent/ES396293A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Procedure for the preparation of 1-alkyl-2-aminomethylpyrralidines, characterized in that a 1-alkyl-2-pyrrolidone is reacted with phosgene in a solvent medium at a temperature between -5ºC and + 10ºC, then it is added to the obtained product, whose temperature has been decreased between 0ºC and 20ºC, an alkaline alcoholate, and then nitromethane is added to the mixture brought back to room temperature, and finally the nitromethylene grouping obtained is reduced to aminomethyl grouping. (Machine-translation by Google Translate, not legally binding)
ES396293A 1970-11-10 1971-10-22 Preparation of 1-alkyl-2-aminomethyl-pyrrolidines Expired ES396293A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1662870A CH532035A (en) 1970-11-10 1970-11-10 New process for the preparation of 1-alkyl-2-amino-methylpyrrolidines

Publications (1)

Publication Number Publication Date
ES396293A1 true ES396293A1 (en) 1974-05-01

Family

ID=4418871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES396293A Expired ES396293A1 (en) 1970-11-10 1971-10-22 Preparation of 1-alkyl-2-aminomethyl-pyrrolidines

Country Status (27)

Country Link
AT (1) AT311952B (en)
AU (1) AU464960B2 (en)
BE (1) BE773979A (en)
BG (1) BG21605A3 (en)
CA (1) CA940533A (en)
CH (1) CH532035A (en)
CS (1) CS186206B2 (en)
DE (1) DE2152371A1 (en)
DK (1) DK145573C (en)
ES (1) ES396293A1 (en)
FI (1) FI54471C (en)
FR (1) FR2111371A5 (en)
GB (1) GB1374818A (en)
HU (1) HU162787B (en)
IE (1) IE35775B1 (en)
IL (1) IL37994A (en)
IT (1) IT1043845B (en)
LU (1) LU64227A1 (en)
MC (1) MC896A1 (en)
NL (1) NL7114901A (en)
OA (1) OA03823A (en)
PH (1) PH12022A (en)
PL (1) PL81412B1 (en)
SE (1) SE376415B (en)
YU (1) YU34672B (en)
ZA (1) ZA716998B (en)
ZM (1) ZM15171A1 (en)

Also Published As

Publication number Publication date
PH12022A (en) 1978-10-06
MC896A1 (en) 1972-06-22
NL7114901A (en) 1972-05-15
IL37994A (en) 1974-10-22
GB1374818A (en) 1974-11-20
AU464960B2 (en) 1975-09-11
IE35775B1 (en) 1976-05-12
DK145573B (en) 1982-12-13
OA03823A (en) 1971-12-24
FI54471C (en) 1978-12-11
SE376415B (en) 1975-05-26
BG21605A3 (en) 1976-07-20
IE35775L (en) 1972-05-10
IT1043845B (en) 1980-02-29
HU162787B (en) 1973-04-28
DE2152371A1 (en) 1972-06-22
DK145573C (en) 1983-05-30
CH532035A (en) 1972-12-31
CS186206B2 (en) 1978-11-30
BE773979A (en) 1972-04-17
YU34672B (en) 1979-12-31
PL81412B1 (en) 1975-08-30
AT311952B (en) 1973-12-10
IL37994A0 (en) 1971-12-29
ZA716998B (en) 1972-07-26
CA940533A (en) 1974-01-22
AU3479071A (en) 1973-05-03
YU282371A (en) 1979-07-10
LU64227A1 (en) 1972-05-29
ZM15171A1 (en) 1972-07-21
FR2111371A5 (en) 1972-06-02
FI54471B (en) 1978-08-31

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