ES396031A1 - Un procedimiento para la preparacion de un 6,6 - difluor - 11 alfa, 16 alfa, 17 alfa - trihidroxi - 4 - pregnen - 3,20 - diona. - Google Patents
Un procedimiento para la preparacion de un 6,6 - difluor - 11 alfa, 16 alfa, 17 alfa - trihidroxi - 4 - pregnen - 3,20 - diona.Info
- Publication number
- ES396031A1 ES396031A1 ES396031A ES396031A ES396031A1 ES 396031 A1 ES396031 A1 ES 396031A1 ES 396031 A ES396031 A ES 396031A ES 396031 A ES396031 A ES 396031A ES 396031 A1 ES396031 A1 ES 396031A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- trihydroxy
- dione
- ketals
- 9alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000005805 hydroxylation reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/939—Rhizopus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11161571A | 1971-02-01 | 1971-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES396031A1 true ES396031A1 (es) | 1975-02-16 |
Family
ID=22339486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396031A Expired ES396031A1 (es) | 1971-02-01 | 1971-10-15 | Un procedimiento para la preparacion de un 6,6 - difluor - 11 alfa, 16 alfa, 17 alfa - trihidroxi - 4 - pregnen - 3,20 - diona. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3718673A (enExample) |
| AT (1) | AT308294B (enExample) |
| AU (1) | AU3452371A (enExample) |
| BE (1) | BE774754A (enExample) |
| CA (1) | CA945139A (enExample) |
| DE (1) | DE2149798A1 (enExample) |
| DK (1) | DK129514B (enExample) |
| ES (1) | ES396031A1 (enExample) |
| FR (1) | FR2124218B1 (enExample) |
| GB (3) | GB1363460A (enExample) |
| IL (1) | IL37798A0 (enExample) |
| NL (1) | NL7113713A (enExample) |
| SU (1) | SU438181A3 (enExample) |
| ZA (1) | ZA716382B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272446A (en) * | 1974-02-27 | 1981-06-09 | Pierrel S.P.A. | Steroids and process for preparing the same |
| NL7502252A (nl) * | 1974-02-27 | 1975-08-29 | Pierrel Spa | Werkwijze voor het bereiden van een geneesmid- del met anti-inflammatoire werking, gevormd ge- neesmiddel verkregen volgens deze werkwijze alsmede werkwijze voor het bereiden van in het geneesmiddel gebruikte nieuwe steroiden. |
| DE2655570A1 (de) * | 1975-12-12 | 1977-06-16 | Ciba Geigy Ag | Neue polyhalogensteroide und verfahren zu ihrer herstellung |
| DE3173923D1 (en) * | 1980-12-23 | 1986-04-03 | Schering Ag | Process for the preparation of 11-beta, 21-dihydroxy-2'-methyl-5'-beta-h-1,4-pregnadieno-(16,17-d)-oxazole-3,20-dione |
| CN102061320B (zh) * | 2010-12-02 | 2013-04-03 | 浙江仙琚制药股份有限公司 | 11α，17α-二羟基-雄甾-4-烯-3，20-二酮的制备方法 |
| US9109005B2 (en) | 2012-02-23 | 2015-08-18 | Boehringer Ingelheim International Gmbh | Method for manufacturing of ciclesonide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3338928A (en) * | 1965-09-09 | 1967-08-29 | Syntex Corp | Fused halocyclopropyl steroids |
| US3546215A (en) * | 1967-10-18 | 1970-12-08 | Syntex Corp | 6-gem-difluoro steroids |
-
1971
- 1971-02-01 US US00111615A patent/US3718673A/en not_active Expired - Lifetime
- 1971-09-22 DK DK463071AA patent/DK129514B/da unknown
- 1971-09-23 ZA ZA716382A patent/ZA716382B/xx unknown
- 1971-09-24 GB GB437374A patent/GB1363460A/en not_active Expired
- 1971-09-24 GB GB4472871A patent/GB1363458A/en not_active Expired
- 1971-09-27 CA CA123,803A patent/CA945139A/en not_active Expired
- 1971-09-27 IL IL37798A patent/IL37798A0/xx unknown
- 1971-10-06 DE DE19712149798 patent/DE2149798A1/de active Pending
- 1971-10-06 NL NL7113713A patent/NL7113713A/xx unknown
- 1971-10-13 AU AU34523/71A patent/AU3452371A/en not_active Expired
- 1971-10-14 AT AT888171A patent/AT308294B/de not_active IP Right Cessation
- 1971-10-15 ES ES396031A patent/ES396031A1/es not_active Expired
- 1971-10-28 FR FR7138737A patent/FR2124218B1/fr not_active Expired
- 1971-10-29 BE BE774754A patent/BE774754A/xx unknown
-
1972
- 1972-01-27 SU SU1742287A patent/SU438181A3/ru active
-
1974
- 1974-01-30 GB GB437271*[A patent/GB1363459A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2149798A1 (de) | 1972-08-03 |
| IL37798A0 (en) | 1971-11-29 |
| NL7113713A (enExample) | 1972-08-03 |
| GB1363460A (en) | 1974-08-14 |
| AT308294B (de) | 1973-06-25 |
| AU3452371A (en) | 1973-04-19 |
| DK129514B (da) | 1974-10-21 |
| GB1363459A (en) | 1974-08-14 |
| CA945139A (en) | 1974-04-09 |
| DK129514C (enExample) | 1975-03-17 |
| SU438181A3 (ru) | 1974-07-30 |
| BE774754A (fr) | 1972-05-02 |
| GB1363458A (en) | 1974-08-14 |
| FR2124218B1 (enExample) | 1975-03-14 |
| FR2124218A1 (enExample) | 1972-09-22 |
| ZA716382B (en) | 1972-07-26 |
| US3718673A (en) | 1973-02-27 |
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