ES393021A1 - Procedure for the preparation of 4-sulfamoil-meta-toluidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 4-sulfamoil-meta-toluidine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES393021A1
ES393021A1 ES393021A ES393021A ES393021A1 ES 393021 A1 ES393021 A1 ES 393021A1 ES 393021 A ES393021 A ES 393021A ES 393021 A ES393021 A ES 393021A ES 393021 A1 ES393021 A1 ES 393021A1
Authority
ES
Spain
Prior art keywords
general formula
compounds
radical
indicated above
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES393021A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES393021A1 publication Critical patent/ES393021A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of 4-sulfamoyl-meta-toluidine derivatives of the general formula I **(See formula)** in which R1 signifies a phenyl, furyl or thionyl radical, R2 signifies the carboxyl or tetrazolyl group (5) and n signifies numbers 1 and 2, and their pharmacologically compatible salts, characterized in that a) compounds of the general formula are reacted II **(See formula)** in which R3 has the same meaning as R2 or represents a group capable of being transformed into R2, Y means hydrogen or an acyl radical and X means a halogen atom or a nitro group, with amines of the general formula III H2N - (CH2) n - R1 (III), in which R1 and n have the meanings indicated above; or b) compounds of the general formula IV are reacted **(See formula)** in which R3 and Y have the meanings indicated above, with compounds of the general formula V Z - (CH2) n - R1 (V) in which R1 and n have the meanings indicated above and Z constitutes a reactive ester group, or with compounds of the general formula VI OHC - (CH2) m - R1 (VI) wherein R1 has the meanings indicated above and m means the numbers 0 or 1, and optionally hydrogenates in a manner known per se at the same time or thereafter; and in the case in which R3 represents a group capable of being transformed into a carboxyl group or a tetrazolyl radical (5), it becomes, in a manner known per se, into the radical R2 and, if Y represents an acyl radical, it is separated this in a manner known per se, after which the compounds I obtained are transformed, if desired, into their pharmacologically compatible salts. (Machine-translation by Google Translate, not legally binding)
ES393021A 1970-07-15 1971-07-08 Procedure for the preparation of 4-sulfamoil-meta-toluidine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES393021A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702034986 DE2034986A1 (en) 1970-07-15 1970-07-15 4 sulfamoyl m toluidine derivatives

Publications (1)

Publication Number Publication Date
ES393021A1 true ES393021A1 (en) 1973-08-01

Family

ID=5776770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES393021A Expired ES393021A1 (en) 1970-07-15 1971-07-08 Procedure for the preparation of 4-sulfamoil-meta-toluidine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (10)

Country Link
AT (2) AT310165B (en)
CA (1) CA975362A (en)
CH (2) CH572903A5 (en)
DE (1) DE2034986A1 (en)
ES (1) ES393021A1 (en)
FR (1) FR2100912B1 (en)
GB (1) GB1296333A (en)
NL (1) NL7109697A (en)
SU (1) SU485594A4 (en)
ZA (1) ZA714539B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2232457A1 (en) * 1972-07-01 1974-01-10 Boehringer Mannheim Gmbh NEW 3-ALKYL-4-SULFAMOYLANILINE DERIVATIVES
DE2334973A1 (en) * 1973-07-10 1975-01-23 Boehringer Mannheim Gmbh NEW BIPHENYL DERIVATIVES
DE3041812A1 (en) * 1980-11-06 1982-06-16 Hoechst Ag, 6000 Frankfurt BASICLY SUBSTITUTED 5-PHENYL TETRAZOLES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1220436B (en) * 1964-10-21 1966-07-07 Hoechst Ag Process for the preparation of sulfamylanthranilic acids
DE1815922C3 (en) * 1968-12-20 1979-04-26 Boehringer Mannheim Gmbh, 6800 Mannheim 5-phenyltetrazole derivatives

Also Published As

Publication number Publication date
FR2100912B1 (en) 1974-10-18
CH572903A5 (en) 1976-02-27
NL7109697A (en) 1972-01-18
AT310744B (en) 1973-10-10
AT310165B (en) 1973-09-25
SU485594A4 (en) 1975-09-25
DE2034986A1 (en) 1972-01-20
GB1296333A (en) 1972-11-15
AU3112271A (en) 1973-01-18
CA975362A (en) 1975-09-30
FR2100912A1 (en) 1972-03-24
CH568970A5 (en) 1975-11-14
ZA714539B (en) 1972-04-26

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