ES388783A1 - Pregna-4,9-diene processes for its preparation and compositions thereof - Google Patents
Pregna-4,9-diene processes for its preparation and compositions thereofInfo
- Publication number
- ES388783A1 ES388783A1 ES388783A ES388783A ES388783A1 ES 388783 A1 ES388783 A1 ES 388783A1 ES 388783 A ES388783 A ES 388783A ES 388783 A ES388783 A ES 388783A ES 388783 A1 ES388783 A1 ES 388783A1
- Authority
- ES
- Spain
- Prior art keywords
- pregna
- diene
- formula
- 13beta
- 17alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Preparation procedure for 3,20-dioxo-13beta-ethyl-17alpha-methyl-18,19-dinor-pregna-4,9-diene of formula I **(See formula)** characterized in that the alcohol function in position 20 of the 3-oxo-13beta-ethyl-17alpha-methyl-20alpha-hydroxy-18,19-dinor-pregna-4,9-diene of formula IIA is oxidized **(See formula)** or of 3-oxo-13beta-ethyl-17alpha-methyl-20beta-hydroxy-18,19-dinor-pregna-4,9-diene of formula IIB **(See formula)** or of a mixture of these two compounds, by means of an oxidizing agent, such as chromic anhydride, in the presence of sulfuric acid, in acetone medium, and the desired compound is isolated. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR707007551A FR2081561B1 (en) | 1970-03-03 | 1970-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES388783A1 true ES388783A1 (en) | 1974-02-16 |
Family
ID=9051572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES388783A Expired ES388783A1 (en) | 1970-03-03 | 1971-03-02 | Pregna-4,9-diene processes for its preparation and compositions thereof |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS5343497B1 (en) |
AT (1) | AT307636B (en) |
BE (1) | BE763660A (en) |
CA (1) | CA934367A (en) |
CH (1) | CH536829A (en) |
DE (1) | DE2109853B2 (en) |
DK (1) | DK124127B (en) |
ES (1) | ES388783A1 (en) |
FR (1) | FR2081561B1 (en) |
GB (1) | GB1323383A (en) |
IL (1) | IL36214A (en) |
NL (1) | NL169592C (en) |
SE (1) | SE368397B (en) |
ZA (1) | ZA711131B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1173408B (en) * | 1984-02-29 | 1987-06-24 | Hudson Italiana Spa | VENTILATOR, OF THE CAVE Bladed Type, WITH THE INSIDE OF EACH VACUUM VACUUM |
DE102007027636A1 (en) * | 2007-06-12 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | 17β-Cyano-18α-homo-19-nor-androst-4-ene derivative, its use and the derivative-containing drug |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1487510A (en) * | 1965-06-01 | 1967-07-07 | Merck & Co Inc | Process for the production of gonenols and substituted gonadienols |
-
1970
- 1970-03-03 FR FR707007551A patent/FR2081561B1/fr not_active Expired
-
1971
- 1971-02-17 IL IL36214A patent/IL36214A/en unknown
- 1971-02-22 ZA ZA711131A patent/ZA711131B/en unknown
- 1971-03-02 NL NLAANVRAGE7102735,A patent/NL169592C/en not_active IP Right Cessation
- 1971-03-02 SE SE02671/71A patent/SE368397B/xx unknown
- 1971-03-02 JP JP1043271A patent/JPS5343497B1/ja active Pending
- 1971-03-02 CH CH302971A patent/CH536829A/en not_active IP Right Cessation
- 1971-03-02 ES ES388783A patent/ES388783A1/en not_active Expired
- 1971-03-02 CA CA106701A patent/CA934367A/en not_active Expired
- 1971-03-02 AT AT177571A patent/AT307636B/en not_active IP Right Cessation
- 1971-03-02 DE DE2109853A patent/DE2109853B2/en active Granted
- 1971-03-02 BE BE763660A patent/BE763660A/en not_active IP Right Cessation
- 1971-03-02 DK DK95871AA patent/DK124127B/en not_active IP Right Cessation
- 1971-04-19 GB GB2297071A patent/GB1323383A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2081561A1 (en) | 1971-12-10 |
BE763660A (en) | 1971-09-02 |
JPS5343497B1 (en) | 1978-11-20 |
CA934367A (en) | 1973-09-25 |
SE368397B (en) | 1974-07-01 |
CH536829A (en) | 1973-05-15 |
FR2081561B1 (en) | 1973-04-06 |
IL36214A (en) | 1974-09-10 |
DE2109853B2 (en) | 1979-06-21 |
GB1323383A (en) | 1973-07-11 |
DE2109853A1 (en) | 1971-09-23 |
DK124127B (en) | 1972-09-18 |
IL36214A0 (en) | 1971-04-28 |
NL7102735A (en) | 1971-09-07 |
DE2109853C3 (en) | 1980-02-21 |
ZA711131B (en) | 1972-03-29 |
AT307636B (en) | 1973-05-25 |
NL169592C (en) | 1982-08-02 |
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