ES387973A1 - Procedimiento para la obtencion de 1,4 - dihidropiridinas de efectos coronarios. - Google Patents

Procedimiento para la obtencion de 1,4 - dihidropiridinas de efectos coronarios.

Info

Publication number
ES387973A1
ES387973A1 ES387973A ES387973A ES387973A1 ES 387973 A1 ES387973 A1 ES 387973A1 ES 387973 A ES387973 A ES 387973A ES 387973 A ES387973 A ES 387973A ES 387973 A1 ES387973 A1 ES 387973A1
Authority
ES
Spain
Prior art keywords
carbon atoms
substituted
alkenyl
effect
alkinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES387973A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES387973A1 publication Critical patent/ES387973A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
ES387973A 1970-02-05 1971-02-05 Procedimiento para la obtencion de 1,4 - dihidropiridinas de efectos coronarios. Expired ES387973A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2005116A DE2005116C3 (de) 1970-02-05 1970-02-05 Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester

Publications (1)

Publication Number Publication Date
ES387973A1 true ES387973A1 (es) 1974-01-16

Family

ID=5761434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES387973A Expired ES387973A1 (es) 1970-02-05 1971-02-05 Procedimiento para la obtencion de 1,4 - dihidropiridinas de efectos coronarios.

Country Status (17)

Country Link
US (1) US4048171A (es)
JP (1) JPS5550021B1 (es)
AT (1) AT302302B (es)
BE (1) BE762580A (es)
CA (1) CA944768A (es)
CH (1) CH553780A (es)
CS (1) CS161771B2 (es)
DE (1) DE2005116C3 (es)
DK (1) DK135282C (es)
ES (1) ES387973A1 (es)
FR (1) FR2150555B1 (es)
GB (2) GB1328479A (es)
IE (1) IE34896B1 (es)
IL (1) IL36018A0 (es)
NL (1) NL171580C (es)
YU (1) YU18471A (es)
ZA (1) ZA71438B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
GB1426499A (en) * 1973-10-02 1976-02-25 I Organischeskogo Sinteza Akad Pharmaceutical composition for treating liver diseases
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
FR2405937A1 (fr) * 1977-10-14 1979-05-11 Labaz Nouveaux derives de dihydropyridine, leur procede de preparation et leur application
DE2844130A1 (de) * 1977-10-14 1979-04-26 Labaz Neue dihydropyridine und deren verwendung
DE3021958A1 (de) * 1980-06-12 1981-12-24 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4520131A (en) * 1983-03-03 1985-05-28 Usv Pharmaceutical Antihypertensive N-substituted 1,4-dihydropyridines
DE3410645A1 (de) * 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
US4683234A (en) * 1984-05-19 1987-07-28 Suntory Limited 2,6-Dimethyl-3N,5-disubstituted-4-(substituted phenyl)3,4-dihydropyrimidine compounds and a method for treating disorders of cardiocircular system
DE3432563A1 (de) * 1984-09-05 1986-03-13 Bayer Ag, 5090 Leverkusen Neue pyridylethyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimittel
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
US5202330A (en) * 1985-06-03 1993-04-13 E. R. Squibb & Sons, Inc. 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters
DE3677319D1 (de) * 1985-10-22 1991-03-07 Sanwa Kagaku Kenkyusho Co Pharmazeutische 1,4-dihydropyridinderivate, ihre salze und herstellung.
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
US4753946A (en) * 1987-04-08 1988-06-28 E. R. Squibb & Sons, Inc. Pyrimidinecarboxylic acid derivatives
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
EP2311806A3 (en) * 1996-01-29 2011-08-10 The United States of America, Represented by the Secretary, Department of Health and Human Services Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists
US6316423B1 (en) 1996-04-10 2001-11-13 The United States Of America As Represented By The Departmant Of Health And Human Services Method of treating ischemic, hypoxic and anoxic brain damage
CA2336967C (en) 1998-07-10 2010-06-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists
AU2001230913B2 (en) * 2000-01-14 2005-06-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
WO2011068978A1 (en) 2009-12-02 2011-06-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives and dendrimer conjugates thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325505A (en) * 1965-02-24 1967-06-13 Smith Kline French Lab 4-cycloalkyl(or cycloalkenyl)-dihydropyridines
US3511847A (en) * 1967-02-07 1970-05-12 Smithkline Corp 2,6-di-lower alkyl - 1,4-dihydro - 4-(2-trifluoromethylphenyl) - 3,5 - pyridinedicarboxylic acid esters
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US3455939A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(4-chloro-3-sulfamoylphenyl)-1,4-dihydropyridines
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
DE2013431C3 (de) * 1970-03-20 1979-12-20 Bayer Ag, 5090 Leverkusen 4-Azidophenyl-l,4-dihydropyridin-3,5-dicarbonsäureester
DE1963186C3 (de) * 1969-12-17 1979-02-15 Bayer Ag, 5090 Leverkusen Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate

Also Published As

Publication number Publication date
CA944768A (en) 1974-04-02
DE2005116C3 (de) 1980-02-14
NL171580C (nl) 1983-04-18
GB1326491A (en) 1973-08-15
JPS5550021B1 (es) 1980-12-16
DK135282B (da) 1977-03-28
NL7101234A (es) 1971-08-09
DK135282C (da) 1977-08-15
FR2150555B1 (es) 1974-09-06
NL171580B (nl) 1982-11-16
YU18471A (en) 1978-12-31
CS161771B2 (es) 1975-06-10
IE34896B1 (en) 1975-09-17
ZA71438B (en) 1971-10-27
IE34896L (en) 1971-08-05
FR2150555A1 (es) 1973-04-13
IL36018A0 (en) 1971-03-24
DE2005116B2 (de) 1979-06-07
BE762580A (fr) 1971-08-05
AT302302B (de) 1972-10-10
GB1328479A (en) 1973-08-30
CH553780A (de) 1974-09-13
DE2005116A1 (de) 1971-09-02
US4048171A (en) 1977-09-13

Similar Documents

Publication Publication Date Title
ES387973A1 (es) Procedimiento para la obtencion de 1,4 - dihidropiridinas de efectos coronarios.
ES440345A1 (es) Procedimiento para la preparacion de 2-tetrahidrofurfuril-6,7-benzomorfanos.
FR2361901A1 (fr) Derives de substitution de nucleotides et medicament contenant ces substances
ES474562A1 (es) Procedimiento para la obtencion de derivados de 1-alcanoil- prolina
GB1384504A (en) Bridgeheadheterocyclic compounds their production and their medicinal use
ES368982A1 (es) Un procedimiento para preparar una sustancia sazonante de alimentos.
GB1374979A (en) 3,5-dioxopiperazine derivatives
ES393840A1 (es) Procedimiento para la obtencion de soluciones anhidras de peroxido de hidrogeno.
ES389180A1 (es) Procedimiento para la preparacion de derivados de la dihi- dro-3,4 isoquinoleina.
ES439927A1 (es) Procedimiento para la obtencion de 7-metoxi-6-tiatetracicli-nas.
GB1335783A (en) Anti-seborrhoeic compositions
FR2408608A1 (fr) Nouvel antibiotique denomme ps-5 et ses derives doues d'activite inhibitrice de la b-lactamase et leur procede de preparation
SE8103106L (sv) Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner
SE417427B (sv) Sett att framstella 5,6-benso-gamma-pyronderivat
ES362615A1 (es) Un metodo para evitar la coloracion de composicion de vita-mina c.
BE769798A (fr) Preparation d'hydroperoxyde de cyclohexyle par oxydation de cyclohexan
ES421741A1 (es) Procedimiento para preparar derivados triazolicos.
SE7700172L (sv) Forfarande for framstellning av 2-oxopyrrolidin-n-alkanoylamid
GB1331161A (en) Amino-s-triazolylbenzenesulphonamides
ES416971A1 (es) Procedimiento para la preparacion de derivados isoquinoli- na.
ATA1069672A (de) Nachgiebige befestigung von leitschienen an gelandern, pfosten, stehern, wanden u.dgl.
FR2288516A2 (fr) Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
GB1314956A (en) Chromone compounds
GB1298057A (en) Bis(aminoalkylsulphamoyl)anthraquinones
ES445343A1 (es) Procedimiento para la preparacion de derivados cuaternarios de xantinil-alcohil-nortropina.