ES382075A1 - Mutilin derivatives - Google Patents

Mutilin derivatives

Info

Publication number
ES382075A1
ES382075A1 ES382075A ES382075A ES382075A1 ES 382075 A1 ES382075 A1 ES 382075A1 ES 382075 A ES382075 A ES 382075A ES 382075 A ES382075 A ES 382075A ES 382075 A1 ES382075 A1 ES 382075A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
carboxyl
iii
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES382075A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of ES382075A1 publication Critical patent/ES382075A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for obtaining pleuromutilin derivatives of formula Ia, **(See formula)** wherein R1 is hydrogen, chlorine, bromine, iodine, thiocyanate, azido, dithiocarbonic acid-O-C1-C5-alkyl, (N, N-tetramethylene-thiocarbomoyl) -mercapto; -S-phenyl, -S-phenyl substituted by carboxyl or by one or two hydroxyl radicals, -S-pyridyl, -S-benzyl, -S-alkyl (C1 to C5), or -S-alkyl (C1 to C5) substituted by one or more amino, hydroxyl or carboxyl radicals; characterized in that 14-deoxy-14-tosyloxyacetoxyutiline of formula II is reacted, **(See formula)** with a compound of formula III, Me - R1 III where R1 has the meaning indicated above, and Me is an alkali metal. (Machine-translation by Google Translate, not legally binding)
ES382075A 1969-07-25 1970-07-23 Mutilin derivatives Expired ES382075A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT722369A AT301753B (en) 1969-07-25 1969-07-25 Process for the preparation of new pleuromutilin derivatives

Publications (1)

Publication Number Publication Date
ES382075A1 true ES382075A1 (en) 1973-04-01

Family

ID=3593920

Family Applications (3)

Application Number Title Priority Date Filing Date
ES382075A Expired ES382075A1 (en) 1969-07-25 1970-07-23 Mutilin derivatives
ES388613A Expired ES388613A1 (en) 1969-07-25 1971-02-25 Mutilin derivatives
ES388614A Expired ES388614A1 (en) 1969-07-25 1971-02-25 Mutilin derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES388613A Expired ES388613A1 (en) 1969-07-25 1971-02-25 Mutilin derivatives
ES388614A Expired ES388614A1 (en) 1969-07-25 1971-02-25 Mutilin derivatives

Country Status (13)

Country Link
JP (2) JPS5010590B1 (en)
AT (1) AT301753B (en)
CA (1) CA986102A (en)
CS (1) CS172913B2 (en)
DE (2) DE2036027C3 (en)
ES (3) ES382075A1 (en)
FR (1) FR2059559B1 (en)
GB (1) GB1312148A (en)
IL (1) IL34980A (en)
NL (1) NL7010444A (en)
PL (2) PL88867B1 (en)
SE (1) SE369712B (en)
ZA (1) ZA705091B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208326A (en) * 1971-10-05 1980-06-17 Sandoz Ltd. Pleuromutilin esters
BE789629A (en) * 1971-10-05 1973-04-03 Sandoz Sa NEW DERIVATIVES OF PLEUROMUTILINE, THEIR PREPARATION AND THERAPEUTIC APPLICATION
US4107164A (en) * 1971-10-05 1978-08-15 Sandoz Ltd. Certain pleuromulilin ester derivatives
EP0013768B1 (en) * 1979-01-12 1984-02-01 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
EP2014640A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
EP2014645A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
WO2021219399A1 (en) * 2020-04-28 2021-11-04 Nabriva Therapeutics GmbH Novel 12-epi-mutilin compounds, process for preparing the same and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT261804B (en) * 1964-04-17 1968-05-10 Biochemie Gmbh Process for the production of new water-soluble, antibiotic compounds

Also Published As

Publication number Publication date
FR2059559A1 (en) 1971-06-04
ES388613A1 (en) 1974-02-16
DE2066118C3 (en) 1981-07-16
PL79777B1 (en) 1975-06-30
CA986102A (en) 1976-03-23
ZA705091B (en) 1972-02-23
PL88867B1 (en) 1976-10-30
ES388614A1 (en) 1974-02-16
AT301753B (en) 1972-09-25
JPS5010857B1 (en) 1975-04-24
CS172913B2 (en) 1977-01-28
JPS5010590B1 (en) 1975-04-22
NL7010444A (en) 1971-01-27
IL34980A0 (en) 1970-09-17
GB1312148A (en) 1973-04-04
DE2036027C3 (en) 1981-12-17
FR2059559B1 (en) 1973-08-10
DE2036027B2 (en) 1980-10-23
SE369712B (en) 1974-09-16
IL34980A (en) 1974-09-10
DE2066118B1 (en) 1980-08-28
DE2036027A1 (en) 1971-02-18

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