ES381534A2 - Un procedimiento para la preparacion de nuevos derivados de 1-fenil-2-aminoetanol. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 1-fenil-2-aminoetanol.Info
- Publication number
- ES381534A2 ES381534A2 ES381534A ES381534A ES381534A2 ES 381534 A2 ES381534 A2 ES 381534A2 ES 381534 A ES381534 A ES 381534A ES 381534 A ES381534 A ES 381534A ES 381534 A2 ES381534 A2 ES 381534A2
- Authority
- ES
- Spain
- Prior art keywords
- conh
- benzyl
- formula
- compounds
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 2 - Amino - 1 - hydroxyethyl Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PRJWYFPDHWJLEV-UHFFFAOYSA-N 2-methyl-4-phenylbutan-2-amine Chemical compound CC(C)(N)CCC1=CC=CC=C1 PRJWYFPDHWJLEV-UHFFFAOYSA-N 0.000 abstract 1
- VXWSXLSUWGZOHD-UHFFFAOYSA-N 5-(2-bromoacetyl)-2-hydroxybenzamide Chemical compound NC(=O)C1=CC(C(=O)CBr)=CC=C1O VXWSXLSUWGZOHD-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- WQVZLXWQESQGIF-UHFFFAOYSA-N Labetalol hydrochloride Chemical compound Cl.C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 WQVZLXWQESQGIF-UHFFFAOYSA-N 0.000 abstract 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical class NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- 150000001722 carbon compounds Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- DREKEUSJTBCXKI-UHFFFAOYSA-N methyl 2-hydroxy-5-oxaldehydoylbenzoate;hydrate Chemical compound O.COC(=O)C1=CC(C(=O)C=O)=CC=C1O DREKEUSJTBCXKI-UHFFFAOYSA-N 0.000 abstract 1
- CBHGGHGLDABLAR-UHFFFAOYSA-N methyl 5-(2-amino-1-hydroxyethyl)-2-hydroxybenzoate;hydrochloride Chemical compound Cl.COC(=O)C1=CC(C(O)CN)=CC=C1O CBHGGHGLDABLAR-UHFFFAOYSA-N 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- ZASBYHZJHQFLGN-UHFFFAOYSA-N n-benzyl-4-phenylbutan-2-amine Chemical compound C=1C=CC=CC=1CNC(C)CCC1=CC=CC=C1 ZASBYHZJHQFLGN-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3437969 | 1969-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES381534A2 true ES381534A2 (es) | 1977-03-16 |
Family
ID=10364919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES381534A Expired ES381534A2 (es) | 1969-07-08 | 1970-07-07 | Un procedimiento para la preparacion de nuevos derivados de 1-fenil-2-aminoetanol. |
Country Status (14)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000192A (en) | 1973-05-07 | 1976-12-28 | Allen & Hanburys Limited | Pharmacologically active compounds |
| GB1468673A (en) | 1973-05-07 | 1977-03-30 | Allen & Hanburys Ltd | Substituted benzamides |
| US4173583A (en) | 1975-04-17 | 1979-11-06 | Schering Corporation | Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide |
| DK31578A (da) * | 1977-02-03 | 1978-08-04 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af benzenderivater |
| CA1147342A (en) | 1977-10-12 | 1983-05-31 | Kazuo Imai | Process of producing novel phenylethanolamine derivatives |
| ZA794872B (en) * | 1978-09-20 | 1980-11-26 | Schering Corp | A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it |
| JPS55124742A (en) * | 1979-03-20 | 1980-09-26 | Kyowa Hakko Kogyo Co Ltd | Novel aminoalcohol derivative |
| IT1194406B (it) * | 1983-09-27 | 1988-09-22 | Scharper S P A | Procedimento per la preparazione di 2-idrossi-5-01-idrossi-2-((4-fenil-2-butil)ammino) etil benzammide |
| IL99436A (en) * | 1990-09-11 | 1999-03-12 | Schering Corp | Process for the preparation of albuterol, and hydrates of the intermediates arylglyoxal and their boron complex ariethanolamine |
| AU2002219920A1 (en) * | 2000-11-28 | 2002-06-11 | Sunesis Pharmaceuticals, Inc. | Salicylate analogs as interleukin-4 antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
-
1969
- 1969-07-08 GB GB3437969A patent/GB1266058A/en not_active Expired
- 1969-08-07 CY CY806A patent/CY806A/xx unknown
-
1970
- 1970-06-24 IE IE826/70A patent/IE34326B1/xx unknown
- 1970-06-26 ZA ZA704414*A patent/ZA704414B/xx unknown
- 1970-06-30 CA CA086,855A patent/CA983524A/en not_active Expired
- 1970-07-02 BE BE752892D patent/BE752892R/xx active
- 1970-07-07 SE SE7009422A patent/SE372935B/xx unknown
- 1970-07-07 DK DK352570A patent/DK133279C/da active
- 1970-07-07 ES ES381534A patent/ES381534A2/es not_active Expired
- 1970-07-08 NL NL7010126.A patent/NL162897C/xx not_active IP Right Cessation
- 1970-07-08 FR FR7025336A patent/FR2059495B2/fr not_active Expired
- 1970-07-08 CH CH1031070A patent/CH582647A5/xx not_active IP Right Cessation
-
1975
- 1975-06-19 DK DK278575A patent/DK278575A/da unknown
- 1975-07-08 KE KE2539*UA patent/KE2539A/xx unknown
- 1975-12-30 MY MY140/75A patent/MY7500140A/xx unknown
-
1976
- 1976-04-28 CH CH1031070A patent/CH583170A5/xx not_active IP Right Cessation
- 1976-05-21 CH CH1031070A patent/CH592051A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH582647A5 (enrdf_load_html_response) | 1976-12-15 |
| ZA704414B (en) | 1971-03-31 |
| CH583170A5 (enrdf_load_html_response) | 1976-12-31 |
| NL162897C (nl) | 1980-07-15 |
| GB1266058A (enrdf_load_html_response) | 1972-03-08 |
| CH592051A5 (enrdf_load_html_response) | 1977-10-14 |
| FR2059495A2 (enrdf_load_html_response) | 1971-06-04 |
| FR2059495B2 (enrdf_load_html_response) | 1974-04-12 |
| DK133279B (da) | 1976-04-20 |
| IE34326L (en) | 1971-01-08 |
| IE34326B1 (en) | 1975-04-02 |
| KE2539A (en) | 1975-07-18 |
| MY7500140A (en) | 1975-12-31 |
| DK278575A (enrdf_load_html_response) | 1975-09-15 |
| NL162897B (nl) | 1980-02-15 |
| DK133279C (da) | 1976-09-20 |
| SE372935B (enrdf_load_html_response) | 1975-01-20 |
| NL7010126A (enrdf_load_html_response) | 1971-01-12 |
| BE752892R (fr) | 1971-01-04 |
| CA983524A (en) | 1976-02-10 |
| CY806A (en) | 1976-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19881117 |