ES379708A1 - Procedure for the obtaining of quinazoline-2 (ih) -tiona derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of quinazoline-2 (ih) -tiona derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES379708A1 ES379708A1 ES379708A ES379708A ES379708A1 ES 379708 A1 ES379708 A1 ES 379708A1 ES 379708 A ES379708 A ES 379708A ES 379708 A ES379708 A ES 379708A ES 379708 A1 ES379708 A1 ES 379708A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkoxy
- compounds
- reacting
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L13/00—Devices or apparatus for measuring differences of two or more fluid pressure values
- G01L13/02—Devices or apparatus for measuring differences of two or more fluid pressure values using elastically-deformable members or pistons as sensing elements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Abstract
Novel compounds I (including salts of the dialkylamino compounds) wherein x y signifies -CR 2 = N- or R is H, F, Cl, Br, C 1 to C 5 alkyl, C 1 to C, alkoxy or alkylthio, NO 2 , CF 3 or di -C 1 to C 4 alkylamino, n is 1 or 2 provided that when n is 2 the R's (may be same or different) signify H, F, Cl, Br, C 1 to C 5 alkyl or C 1 to C 4 alkoxy, R 1 is C 1 to C 5 alkyl, allyl or propargyl and R 2 is phenyl or Y,Y i -substituted phenyl (Y is F, Cl, Br, C 1 to C 4 alkyl, C 1 to C 4 alkoxy or CF 3 and Y 1 is H, F, Cl, Br, C 1 to C 4 alkyl or C 1 to C 4 alkoxy), are obtained: (a) by interacting phosphorus pentasulphide and compounds III (prepared by reacting compounds IV with a urethane IV are obtained by alkylation of corresponding primary amines ) (b) by reacting IV with a carboxylic acid chloride or bromide and MNCS (M is alkali or alkaline earth metal cation or the ammonium cation) or with the reaction product thereof or with isothiocyanic acid (conveniently prepared in situ) (c) by reacting isothiocyanic acid with compounds VI (prepared by interaction of IV and, e.g. sodium borohydride) or (d) by interacting an aldehyde, Y1 1 C 6 H 4 .CHO, and compounds IX (prepared by saponification of appropriate acylated thioureas R1 is H, F, Cl, Br, C 1 to C 5 alkyl or C 1 to C 4 alkoxy, R1 1 is C 1 to C 5 alkyl, n1 is 1 or 2 provided that when n1 is 2 no more than one R1 is halogen or a branched chain substituent and provided that R1 is other than a branched chain substituent when in the 5- or 8-position, and Y1 1 is H, F, Cl, Br, C 1 to C 3 alkyl or C 1 or C 2 alkoxy). N - Isopropyl - N - (m - tolyl) - N1 - benzoylthiourea is obtained by reacting N-isopropyl-3- methylaniline with benzoyl chloride in the presence of ammonium thiocyanate. Pharmaceutical preparations showing, in particular, activity contain I as active ingredient administration is orally or parenterally.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74180568A | 1968-07-01 | 1968-07-01 | |
| US81638369A | 1969-04-15 | 1969-04-15 | |
| US81947769A | 1969-04-25 | 1969-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES379708A1 true ES379708A1 (en) | 1973-02-01 |
Family
ID=27419277
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES368945A Expired ES368945A1 (en) | 1968-07-01 | 1969-06-30 | Procedure for the obtaining of quinazoline derivatives -2 (1H) - tiona. (Machine-translation by Google Translate, not legally binding) |
| ES379709A Expired ES379709A1 (en) | 1968-07-01 | 1970-05-16 | Procedure for the obtaining of derivatives of quinazoline-2 (1H) -tiona. (Machine-translation by Google Translate, not legally binding) |
| ES379708A Expired ES379708A1 (en) | 1968-07-01 | 1970-05-16 | Procedure for the obtaining of quinazoline-2 (ih) -tiona derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES368945A Expired ES368945A1 (en) | 1968-07-01 | 1969-06-30 | Procedure for the obtaining of quinazoline derivatives -2 (1H) - tiona. (Machine-translation by Google Translate, not legally binding) |
| ES379709A Expired ES379709A1 (en) | 1968-07-01 | 1970-05-16 | Procedure for the obtaining of derivatives of quinazoline-2 (1H) -tiona. (Machine-translation by Google Translate, not legally binding) |
Country Status (15)
| Country | Link |
|---|---|
| BE (1) | BE735343A (en) |
| BG (1) | BG16035A3 (en) |
| CA (1) | CA956950A (en) |
| CH (1) | CH514596A (en) |
| DE (1) | DE1932401C3 (en) |
| DK (1) | DK131151B (en) |
| ES (3) | ES368945A1 (en) |
| FR (1) | FR2012060A1 (en) |
| GB (1) | GB1265548A (en) |
| IE (1) | IE33186B1 (en) |
| IL (1) | IL32504A (en) |
| NL (1) | NL6909804A (en) |
| NO (1) | NO128998B (en) |
| RO (1) | RO56665A (en) |
| SE (1) | SE376421B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2037693C3 (en) * | 1969-08-02 | 1975-01-16 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 1-Cyclopropylmethyl-2 (1 H) -quinazolinone derivatives |
| US9834525B2 (en) | 2014-02-04 | 2017-12-05 | University Of Tennessee Research Foundation | Inhibitors of paxillin function and related compositions and methods |
-
1969
- 1969-05-26 RO RO62704A patent/RO56665A/ro unknown
- 1969-06-11 CH CH889269A patent/CH514596A/en not_active IP Right Cessation
- 1969-06-13 GB GB1265548D patent/GB1265548A/en not_active Expired
- 1969-06-13 NO NO02447/69A patent/NO128998B/no unknown
- 1969-06-16 DK DK323069AA patent/DK131151B/en unknown
- 1969-06-19 SE SE6908762A patent/SE376421B/xx unknown
- 1969-06-26 NL NL6909804A patent/NL6909804A/xx not_active Application Discontinuation
- 1969-06-26 DE DE1932401A patent/DE1932401C3/en not_active Expired
- 1969-06-27 BE BE735343D patent/BE735343A/xx unknown
- 1969-06-28 BG BG012548A patent/BG16035A3/en unknown
- 1969-06-29 IL IL32504A patent/IL32504A/en unknown
- 1969-06-30 FR FR6921993A patent/FR2012060A1/fr not_active Withdrawn
- 1969-06-30 CA CA055,705A patent/CA956950A/en not_active Expired
- 1969-06-30 IE IE891/69A patent/IE33186B1/en unknown
- 1969-06-30 ES ES368945A patent/ES368945A1/en not_active Expired
-
1970
- 1970-05-16 ES ES379709A patent/ES379709A1/en not_active Expired
- 1970-05-16 ES ES379708A patent/ES379708A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE376421B (en) | 1975-05-26 |
| GB1265548A (en) | 1972-03-01 |
| IE33186L (en) | 1970-01-01 |
| NL6909804A (en) | 1970-01-05 |
| IE33186B1 (en) | 1974-04-17 |
| CH514596A (en) | 1971-10-31 |
| IL32504A0 (en) | 1969-08-27 |
| FR2012060A1 (en) | 1970-03-13 |
| IL32504A (en) | 1973-06-29 |
| CA956950A (en) | 1974-10-29 |
| DK131151B (en) | 1975-06-02 |
| ES379709A1 (en) | 1973-01-16 |
| BE735343A (en) | 1969-12-29 |
| BG16035A3 (en) | 1972-05-20 |
| DE1932401A1 (en) | 1970-01-08 |
| DE1932401B2 (en) | 1979-08-16 |
| DE1932401C3 (en) | 1980-04-17 |
| ES368945A1 (en) | 1971-07-16 |
| RO56665A (en) | 1974-06-01 |
| DK131151C (en) | 1975-10-27 |
| NO128998B (en) | 1974-02-11 |
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