ES378368A1 - Procedimiento para la preparacion de 2 - (5-nitro-2-imida- zolil) - ben-cimidazoles. - Google Patents
Procedimiento para la preparacion de 2 - (5-nitro-2-imida- zolil) - ben-cimidazoles.Info
- Publication number
- ES378368A1 ES378368A1 ES70378368A ES378368A ES378368A1 ES 378368 A1 ES378368 A1 ES 378368A1 ES 70378368 A ES70378368 A ES 70378368A ES 378368 A ES378368 A ES 378368A ES 378368 A1 ES378368 A1 ES 378368A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- general formula
- optionally
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 11
- 239000002253 acid Substances 0.000 abstract 4
- 125000003158 alcohol group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 150000004985 diamines Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 2
- ARMIPOZWLTZJQG-UHFFFAOYSA-N 2-(5-nitro-1H-imidazol-2-yl)-1H-benzimidazole Chemical class N1C([N+](=O)[O-])=CN=C1C1=NC2=CC=CC=C2N1 ARMIPOZWLTZJQG-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/325—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups reduction by other means than indicated in C07C209/34 or C07C209/36
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1920635A DE1920635C3 (de) | 1969-04-19 | 1969-04-19 | 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES378368A1 true ES378368A1 (es) | 1972-06-16 |
Family
ID=5732064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES70378368A Expired ES378368A1 (es) | 1969-04-19 | 1970-04-08 | Procedimiento para la preparacion de 2 - (5-nitro-2-imida- zolil) - ben-cimidazoles. |
Country Status (15)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053472A (en) * | 1969-04-19 | 1977-10-11 | Schering Aktiengesellschaft | 2-(5-nitro-2-imidazolyl)-benzimidazoles |
| IT1043840B (it) * | 1971-05-08 | 1980-02-29 | Poli Ind Chimica Spa | Pirimidine 2 5 disostituite e processo per la loro preparazione |
| US3996238A (en) * | 1972-02-08 | 1976-12-07 | Ciba-Geigy Corporation | 4- or 5-Nitroimidazoles and processes for their manufacture |
| BE795636A (fr) * | 1972-02-19 | 1973-08-20 | Schering Ag | Nitroimidazolylpyrimidines, et leur procede de preparation |
| PT78358B (en) * | 1983-04-07 | 1986-05-30 | Smith Kline French Lab | Chemical process |
| US5852011A (en) * | 1994-05-31 | 1998-12-22 | Mitsui Chemicals, Inc. | Benzimidazole derivatives |
| EP0777656B1 (en) * | 1994-08-26 | 2004-04-14 | Auckland Division Cancer Society Of New Zealand (Incorporated) | Novel dna-targeted alkylating agents |
-
1969
- 1969-04-19 DE DE1920635A patent/DE1920635C3/de not_active Expired
-
1970
- 1970-03-27 CS CS2059A patent/CS167896B2/cs unknown
- 1970-04-02 CH CH1820172A patent/CH546768A/xx not_active IP Right Cessation
- 1970-04-02 CH CH491970A patent/CH546774A/xx not_active IP Right Cessation
- 1970-04-08 ES ES70378368A patent/ES378368A1/es not_active Expired
- 1970-04-15 DK DK188570AA patent/DK137758B/da unknown
- 1970-04-17 BE BE749102D patent/BE749102A/xx unknown
- 1970-04-17 NO NO01455/70A patent/NO126624B/no unknown
- 1970-04-17 AT AT351470A patent/AT294075B/de active
- 1970-04-17 SE SE05326/70A patent/SE364962B/xx unknown
- 1970-04-17 FI FI701070A patent/FI52861C/fi active
- 1970-04-17 FR FR707013970A patent/FR2042351B1/fr not_active Expired
- 1970-04-17 ZA ZA702577A patent/ZA702577B/xx unknown
- 1970-04-20 JP JP45033734A patent/JPS4914231B1/ja active Pending
- 1970-04-20 NL NL7005703A patent/NL7005703A/xx not_active Application Discontinuation
- 1970-04-20 GB GB1874370A patent/GB1312056A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CS167896B2 (enrdf_load_stackoverflow) | 1976-05-28 |
| DE1920635A1 (de) | 1970-10-29 |
| DK137758B (da) | 1978-05-01 |
| NO126624B (enrdf_load_stackoverflow) | 1973-03-05 |
| DE1920635B2 (de) | 1978-11-02 |
| SE364962B (enrdf_load_stackoverflow) | 1974-03-11 |
| NL7005703A (enrdf_load_stackoverflow) | 1970-10-21 |
| GB1312056A (en) | 1973-04-04 |
| JPS4914231B1 (enrdf_load_stackoverflow) | 1974-04-05 |
| DK137758C (enrdf_load_stackoverflow) | 1978-10-09 |
| FI52861B (enrdf_load_stackoverflow) | 1977-08-31 |
| DE1920635C3 (de) | 1979-06-28 |
| FR2042351B1 (enrdf_load_stackoverflow) | 1973-07-13 |
| FR2042351A1 (enrdf_load_stackoverflow) | 1971-02-12 |
| CH546774A (de) | 1974-03-15 |
| BE749102A (fr) | 1970-10-19 |
| CH546768A (de) | 1974-03-15 |
| ZA702577B (en) | 1971-01-27 |
| FI52861C (fi) | 1977-12-12 |
| AT294075B (de) | 1971-11-10 |
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