ES375023A1 - Medicaments derived from thiazolidine carboxylic acid - Google Patents

Medicaments derived from thiazolidine carboxylic acid

Info

Publication number
ES375023A1
ES375023A1 ES375023A ES375023A ES375023A1 ES 375023 A1 ES375023 A1 ES 375023A1 ES 375023 A ES375023 A ES 375023A ES 375023 A ES375023 A ES 375023A ES 375023 A1 ES375023 A1 ES 375023A1
Authority
ES
Spain
Prior art keywords
cyclic
formula
heterocyclic
substituted
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES375023A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sogespar SA
Original Assignee
Sogespar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sogespar SA filed Critical Sogespar SA
Publication of ES375023A1 publication Critical patent/ES375023A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Procedure for obtaining thiazolidine carboxylic acid derivatives, which have interesting antitussive and mucolytic properties and which respond to the formula: **(See formula)** in which: R1 represents hydrogen, an alkyl, aryl, cyclic or heterocyclic radical, an OH, alkyloxy or aryloxy, cyclic or heterocyclic, amino or carboxylic, acid or ester radical, with or without all groups capable of being substituted. R2 represents an amino, OH, alkyloxy or aryloxy, cyclic or heterocyclic, mono or dialkylataine radical NHCH2OH or morpholine, all groups being substituted or not being able to be substituted. R3 represents hydrogen, an alkyl, aryl, cyclic or heterocyclic, carboxylic acid or ester radical, characterized in that it is reacted on a sulfur and aminated acid of formula **(See formula)** an aldehyde of the formula R1-CHO and the acid obtained is then optionally converted into an ester or amide by the action of an alcohol or ammonia or one of its homologous substituted salts. (Machine-translation by Google Translate, not legally binding)
ES375023A 1968-12-31 1969-12-30 Medicaments derived from thiazolidine carboxylic acid Expired ES375023A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR182571A FR8266M (en) 1968-12-31 1968-12-31

Publications (1)

Publication Number Publication Date
ES375023A1 true ES375023A1 (en) 1972-03-01

Family

ID=8659685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES375023A Expired ES375023A1 (en) 1968-12-31 1969-12-30 Medicaments derived from thiazolidine carboxylic acid

Country Status (7)

Country Link
BE (1) BE743905A (en)
CA (1) CA959850A (en)
CH (1) CH511248A (en)
DE (1) DE1965343A1 (en)
ES (1) ES375023A1 (en)
FR (1) FR8266M (en)
GB (1) GB1299201A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592905A (en) * 1969-10-30 1971-07-13 Merck & Co Inc Therapeutic methods
FR2222087B1 (en) * 1973-03-22 1976-04-09 Ferlux
IT1190945B (en) * 1982-08-06 1988-02-24 Salus Research Sarm Spa COMPOUND WITH BRONCHO-SECRETOGOGUE, FLUIDIFYING AND ANTITUSSIGENIC ACTION, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
DE3376341D1 (en) * 1982-08-09 1988-05-26 Ajinomoto Kk Method for producing 2-substituted-thiazolidine-4-carboxylic acids
HU195492B (en) * 1984-07-27 1988-05-30 Boehringer Biochemia Srl Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient
ES2034041T3 (en) * 1988-06-29 1993-04-01 Yason S.R.L N-CARBOTOXI-4-THIAZOLIDIN-CARBOXYLIC ACID, PROCESS FOR ITS PREPARATION AND USE AS A MEDICINAL PRODUCT.

Also Published As

Publication number Publication date
CA959850A (en) 1974-12-24
FR8266M (en) 1970-10-26
GB1299201A (en) 1972-12-13
CH511248A (en) 1971-08-15
DE1965343A1 (en) 1970-07-23
BE743905A (en) 1970-05-28

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