ES370497A1 - A procedure for the preparation of a compound of hexahidro-1-h-azepine. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of a compound of hexahidro-1-h-azepine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES370497A1 ES370497A1 ES370497A ES370497A ES370497A1 ES 370497 A1 ES370497 A1 ES 370497A1 ES 370497 A ES370497 A ES 370497A ES 370497 A ES370497 A ES 370497A ES 370497 A1 ES370497 A1 ES 370497A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- lower alkyl
- compound
- integer
- cyclized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Abstract
A procedure for the preparation of a hexahydro-1H-azepine compound, characterized in that the compound has the formula **(See formula)** o is one of its quaternary ammonium or acid addition salts, where R1 is a hydrogen atom, a lower alkyl radical, a benzyl radical or a lower alkanoyl radical, R2 is a lower alkyl radical, R3 is an atom of hydrogen, a lower alkyl, alkenyl, alkynyl, cyclopropylmethyl group, a lower alkanoyl, alkoxycarbonyl, formyl, phenacyl or phenethyl group which may be substituted on the benzene ring or a beta-benzoyethyl radical which may be substituted on the benzene ring, n is the integer 3 or 4, m is 0 or the integer 1 with the expectation that n + m is always equal to 4, R is a hydrogen atom or a lower alkyl radical, when m is 0, or only one atom of hydrogen when m is the integer 1, and the term "lower" means that the radical contains up to 6, preferably up to 4 carbon atoms, where a heterocyclic ring system precursor is cyclized, and if necessary the prod Cyclized product is reduced and optionally the cyclized or reduced product is N-alkylated. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3920168 | 1968-08-16 | ||
GB4206068 | 1968-09-04 | ||
GB4694/69A GB1285025A (en) | 1968-08-16 | 1969-01-28 | Hexahydroazepines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES370497A1 true ES370497A1 (en) | 1972-04-16 |
Family
ID=27254483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES370497A Expired ES370497A1 (en) | 1968-08-16 | 1969-08-14 | A procedure for the preparation of a compound of hexahidro-1-h-azepine. (Machine-translation by Google Translate, not legally binding) |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS505197B1 (en) |
AR (1) | AR194353A1 (en) |
AT (1) | AT312611B (en) |
BE (1) | BE737548A (en) |
CH (3) | CH536843A (en) |
DE (1) | DE1941534C3 (en) |
DK (2) | DK141401B (en) |
ES (1) | ES370497A1 (en) |
FI (1) | FI51479C (en) |
FR (1) | FR2015812A1 (en) |
HU (1) | HU162512B (en) |
IE (1) | IE33382B1 (en) |
IL (1) | IL32801A (en) |
IT (1) | IT1053698B (en) |
NL (1) | NL164275C (en) |
NO (2) | NO132046C (en) |
SE (1) | SE366043B (en) |
YU (2) | YU34124B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1319785A (en) * | 1970-02-06 | 1973-06-06 | Wyeth John & Brother Ltd | Hexahydroazepines |
US3666752A (en) * | 1970-03-09 | 1972-05-30 | Bristol Myers Co | 4,4-diphenylhexahydroazepine compounds |
DE2901180A1 (en) * | 1979-01-13 | 1980-07-24 | Basf Ag | HEXAHYDRO-1,4-OXAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
SE439186B (en) * | 1980-12-04 | 1985-06-03 | Olof Ohrnell | ELASTIC CLUTCH BETWEEN ONE INTERNAL AND EXTERNAL IN RELATION TO EACH CONCENTRIC ROW |
DE3502667A1 (en) * | 1985-01-26 | 1986-07-31 | Klöckner-Humboldt-Deutz AG, 5000 Köln | Centrifugal oil filter for internal combustion engines |
US20070078120A1 (en) * | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
EP3402779A1 (en) * | 2016-01-15 | 2018-11-21 | Esteve Pharmaceuticals, S.A. | 3-ethyl-3-phenylazepane derivatives having multimodal activity against pain |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2740779A (en) * | 1956-04-03 | Substituted azacycloalkanes |
-
1969
- 1969-08-06 IE IE1102/69A patent/IE33382B1/en unknown
- 1969-08-08 IL IL32801A patent/IL32801A/en unknown
- 1969-08-14 ES ES370497A patent/ES370497A1/en not_active Expired
- 1969-08-14 DE DE1941534A patent/DE1941534C3/en not_active Expired
- 1969-08-14 BE BE737548D patent/BE737548A/xx not_active IP Right Cessation
- 1969-08-14 FR FR6928129A patent/FR2015812A1/en not_active Withdrawn
- 1969-08-14 IT IT20967/69A patent/IT1053698B/en active
- 1969-08-15 CH CH1241969A patent/CH536843A/en not_active IP Right Cessation
- 1969-08-15 CH CH340773A patent/CH554865A/en not_active IP Right Cessation
- 1969-08-15 NO NO3311/69A patent/NO132046C/no unknown
- 1969-08-15 JP JP44064669A patent/JPS505197B1/ja active Pending
- 1969-08-15 YU YU2102/69A patent/YU34124B/en unknown
- 1969-08-15 FI FI692393A patent/FI51479C/en active
- 1969-08-15 DK DK439969AA patent/DK141401B/en not_active IP Right Cessation
- 1969-08-15 CH CH1056472A patent/CH554864A/en not_active IP Right Cessation
- 1969-08-15 NL NL6912483.A patent/NL164275C/en not_active IP Right Cessation
- 1969-08-15 SE SE11395/69A patent/SE366043B/xx unknown
- 1969-08-15 HU HUWI160A patent/HU162512B/hu unknown
- 1969-08-18 AT AT789269A patent/AT312611B/en not_active IP Right Cessation
-
1971
- 1971-07-09 DK DK340571A patent/DK150849C/en not_active IP Right Cessation
- 1971-11-30 AR AR239343A patent/AR194353A1/en active
-
1975
- 1975-02-11 NO NO750442A patent/NO142395C/en unknown
- 1975-10-27 YU YU02716/75A patent/YU39170B/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR2015812A1 (en) | 1970-04-30 |
NL164275B (en) | 1980-07-15 |
IE33382B1 (en) | 1974-06-12 |
IL32801A (en) | 1973-06-29 |
CH536843A (en) | 1973-05-15 |
NO142395C (en) | 1980-08-13 |
FI51479B (en) | 1976-09-30 |
HU162512B (en) | 1973-02-28 |
DK141401C (en) | 1980-09-08 |
NL6912483A (en) | 1970-02-18 |
NO750442L (en) | 1970-02-17 |
BE737548A (en) | 1970-02-16 |
JPS505197B1 (en) | 1975-02-28 |
DE1941534B2 (en) | 1979-11-15 |
IE33382L (en) | 1970-02-16 |
YU34124B (en) | 1978-12-31 |
IT1053698B (en) | 1981-10-10 |
FI51479C (en) | 1977-01-10 |
YU271675A (en) | 1982-02-28 |
AT312611B (en) | 1974-01-10 |
YU39170B (en) | 1984-08-31 |
YU210269A (en) | 1978-06-30 |
NO142395B (en) | 1980-05-05 |
DE1941534C3 (en) | 1980-07-24 |
IL32801A0 (en) | 1969-11-12 |
AR194353A1 (en) | 1973-07-13 |
DK150849B (en) | 1987-07-06 |
CH554865A (en) | 1974-10-15 |
NO132046C (en) | 1975-09-10 |
DK150849C (en) | 1988-02-01 |
SE366043B (en) | 1974-04-08 |
CH554864A (en) | 1974-10-15 |
NO132046B (en) | 1975-06-02 |
NL164275C (en) | 1980-12-15 |
DK141401B (en) | 1980-03-10 |
DE1941534A1 (en) | 1970-04-09 |
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