ES370334A2 - A novel tetrahydrobenzazepine derivative, processes for its production and composition containing same - Google Patents

A novel tetrahydrobenzazepine derivative, processes for its production and composition containing same

Info

Publication number
ES370334A2
ES370334A2 ES370334A ES370334A ES370334A2 ES 370334 A2 ES370334 A2 ES 370334A2 ES 370334 A ES370334 A ES 370334A ES 370334 A ES370334 A ES 370334A ES 370334 A2 ES370334 A2 ES 370334A2
Authority
ES
Spain
Prior art keywords
give
formula
reacting
acid addition
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES370334A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES370334A2 publication Critical patent/ES370334A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The novel compound 2-methyl-7-chloro- 2,3,4,5 - tetrahydro - 1H - 3 - benzazepine of Formula I: and its pharmaceutically acceptable acid addition salts, are prepared by treating a compound of Formula II: wherein X is chlorine, bromine or iodine, or an inorganic acid addition salt thereof, with a Lewis acid, preferably at temperatures between 100 and 300 C., and isolating the product of Formula I from the reaction mixture, and, if desired, converting this product into a pharmaceutically acceptable acid addition salt. 1 - (p - Chlorophenyl) - 2 - (2 - chloroethylamino)-propane hydrochloride is prepared by reacting chlorobenzene with propionic acid anhydride to give p-chloropropiophenone, reacting this with sodium borohydride to give 1-(pchlorophenyl)-propanol, treating this with sodium hydrogen sulphate to give p-chloro-#-methylstyrene, reacting this with ethyleneimine to give 1 - (p - chlorophenyl - 2 - (1 - aziridinyl) - propane, and reacting this with hydrogen chloride. Pharmaceutical compositions having an anorexigenic effect, for oral, rectal or parenteral administration, comprise the novel compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, together with a carrier.
ES370334A 1968-08-09 1969-08-08 A novel tetrahydrobenzazepine derivative, processes for its production and composition containing same Expired ES370334A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75138168A 1968-08-09 1968-08-09

Publications (1)

Publication Number Publication Date
ES370334A2 true ES370334A2 (en) 1971-04-16

Family

ID=25021727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES370334A Expired ES370334A2 (en) 1968-08-09 1969-08-08 A novel tetrahydrobenzazepine derivative, processes for its production and composition containing same

Country Status (6)

Country Link
AT (1) AT289812B (en)
DE (1) DE1940512A1 (en)
ES (1) ES370334A2 (en)
FR (1) FR2015400A6 (en)
GB (1) GB1268070A (en)
NL (1) NL6912141A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2016136A1 (en) * 1970-04-04 1971-10-14 C H Boehnnger Sohn, 6507 Ingel heim New 7 acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
CH481110A (en) * 1967-02-17 1969-11-15 Geigy Ag J R Process for the preparation of 1,2,4,5-tetrahydro-3-azepines

Also Published As

Publication number Publication date
GB1268070A (en) 1972-03-22
NL6912141A (en) 1970-02-11
FR2015400A6 (en) 1970-04-24
AT289812B (en) 1971-05-10
DE1940512A1 (en) 1970-10-01

Similar Documents

Publication Publication Date Title
GB1221324A (en) New processes for the production of benzazepine derivatives
GB1234058A (en)
ES357247A1 (en) New tetrahydroazepine derivative, process for its production and compositions containing same
ES431513A1 (en) 2-Heteroaryl-methyl)-5,9{62 -dialkyl-6,7-benzomorphans and salts thereof
GB1506914A (en) 2-dihalophenylamino-2-imidazoline derivatives
US3862152A (en) 3-carbamoylamino-4-phenyl quinoline compounds
GB1411583A (en) Aminophenyl-substituted alkyl-heterocyclic derivatives and processes for producing them
GB1264189A (en)
GB1295228A (en)
ES370334A2 (en) A novel tetrahydrobenzazepine derivative, processes for its production and composition containing same
GB1194505A (en) Piperidinol Derivatives and Process for Preparing Them
GB1470208A (en) Process for preparing benzene derivatives having isocyanao tomethyl group
ES417396A1 (en) A procedure for the production of a pharmaceutical composition. (Machine-translation by Google Translate, not legally binding)
GB1373276A (en) 2-aryl-amino-imidazoline-2 compounds
US3952036A (en) 1,1-(Thiadialkylidene) ferrocene S-oxides
GB1254270A (en) Benzoxazepine derivatives
IL38440A (en) 2-(4,4-ethylenedioxypiperidinoethyl)-3-halophenyl-2-imidazolidinones,their preparation and pharmaceutical compositions containing them
ES430197A1 (en) N-(furyl-or thienyl-methyl)-Desoxy-normorphines and -norcodeines and salt thereof
GB1456946A (en) 6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines
US3373184A (en) Sulfamide derivatives
GB1339010A (en) Tetrazolyl-anthraquinone derivatives
GB936919A (en) Pharmaceutical compositions comprising homochlorcyclizine
US3366660A (en) Dibenzo cycloheptene thioiminoesters
GB1316674A (en) 1-disubstituted-amino pyrazoles and the production thereof
GB1184649A (en) N-Substituted 2-Hydroxymorphinanes and Pharmaceutical Compositions containing them

Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170630