ES367107A1 - Un procedimiento para la preparacion de acido (cis-1,2-epo-xipropil) fosfonico o los esteres o sales del mismo. - Google Patents
Un procedimiento para la preparacion de acido (cis-1,2-epo-xipropil) fosfonico o los esteres o sales del mismo.Info
- Publication number
- ES367107A1 ES367107A1 ES367107A ES367107A ES367107A1 ES 367107 A1 ES367107 A1 ES 367107A1 ES 367107 A ES367107 A ES 367107A ES 367107 A ES367107 A ES 367107A ES 367107 A1 ES367107 A1 ES 367107A1
- Authority
- ES
- Spain
- Prior art keywords
- cis
- salt
- phosphonic acid
- ester
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 8
- 239000002253 acid Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- -1 phosphonic acid compound Chemical class 0.000 abstract 8
- 150000002148 esters Chemical class 0.000 abstract 6
- 239000000047 product Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000007858 starting material Substances 0.000 abstract 4
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001768 cations Chemical class 0.000 abstract 3
- MXMXXUIOCREOTJ-UHFFFAOYSA-N 1,2-dihydroxypropylphosphonic acid Chemical compound CC(O)C(O)P(O)(O)=O MXMXXUIOCREOTJ-UHFFFAOYSA-N 0.000 abstract 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 abstract 2
- 230000008030 elimination Effects 0.000 abstract 2
- 238000003379 elimination reaction Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 abstract 1
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 abstract 1
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- XDUWWDRVSNOFQD-STHAYSLISA-N [(4S,5R)-4-methyl-4,5-dihydrooxadiazol-5-yl]phosphonic acid Chemical compound C[C@@H]1N=NO[C@@H]1P(O)(O)=O XDUWWDRVSNOFQD-STHAYSLISA-N 0.000 abstract 1
- QXDBVADCACWXIT-GBXIJSLDSA-N [(4S,5R)-5-methyl-2-oxo-1,3-dioxolan-4-yl]phosphonic acid Chemical compound C[C@@H]1[C@@H](OC(O1)=O)P(O)(O)=O QXDBVADCACWXIT-GBXIJSLDSA-N 0.000 abstract 1
- XWCIXXXLOAAWPU-IHWYPQMZSA-N [(z)-prop-1-enyl]phosphonic acid Chemical compound C\C=C/P(O)(O)=O XWCIXXXLOAAWPU-IHWYPQMZSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
- 229940024874 benzophenone Drugs 0.000 abstract 1
- 239000012965 benzophenone Substances 0.000 abstract 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical class NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- WLXALCKAKGDNAT-UHFFFAOYSA-N diazoethane Chemical compound CC=[N+]=[N-] WLXALCKAKGDNAT-UHFFFAOYSA-N 0.000 abstract 1
- 229940117389 dichlorobenzene Drugs 0.000 abstract 1
- KWKXNDCHNDYVRT-UHFFFAOYSA-N dodecylbenzene Chemical compound CCCCCCCCCCCCC1=CC=CC=C1 KWKXNDCHNDYVRT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 235000010446 mineral oil Nutrition 0.000 abstract 1
- 239000001272 nitrous oxide Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 238000006385 ozonation reaction Methods 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 abstract 1
- 238000000197 pyrolysis Methods 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72942268A | 1968-05-15 | 1968-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES367107A1 true ES367107A1 (es) | 1971-05-01 |
Family
ID=24930950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES367107A Expired ES367107A1 (es) | 1968-05-15 | 1969-05-12 | Un procedimiento para la preparacion de acido (cis-1,2-epo-xipropil) fosfonico o los esteres o sales del mismo. |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE733048A (nl) |
| BR (1) | BR6908832D0 (nl) |
| CH (1) | CH525247A (nl) |
| DE (1) | DE1924093A1 (nl) |
| ES (1) | ES367107A1 (nl) |
| GB (1) | GB1239159A (nl) |
| IL (1) | IL32123A0 (nl) |
| NL (1) | NL6904508A (nl) |
| SE (1) | SE351659B (nl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3812007A1 (en) | 2019-10-24 | 2021-04-28 | Sandoz Ag | New formulations of fosfomycin with reduced sodium content for parenteral use and methods of producing the same |
-
1969
- 1969-03-24 NL NL6904508A patent/NL6904508A/xx unknown
- 1969-03-31 SE SE04513/69A patent/SE351659B/xx unknown
- 1969-05-01 IL IL32123A patent/IL32123A0/xx unknown
- 1969-05-12 ES ES367107A patent/ES367107A1/es not_active Expired
- 1969-05-12 GB GB1239159D patent/GB1239159A/en not_active Expired
- 1969-05-12 DE DE19691924093 patent/DE1924093A1/de active Pending
- 1969-05-14 BR BR208832/69A patent/BR6908832D0/pt unknown
- 1969-05-14 BE BE733048D patent/BE733048A/xx unknown
- 1969-05-14 CH CH741869A patent/CH525247A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL32123A0 (en) | 1969-07-30 |
| SE351659B (nl) | 1972-12-04 |
| BE733048A (nl) | 1969-11-14 |
| DE1924093A1 (de) | 1970-02-26 |
| GB1239159A (nl) | 1971-07-14 |
| CH525247A (de) | 1972-07-15 |
| NL6904508A (nl) | 1969-11-18 |
| BR6908832D0 (pt) | 1973-01-09 |
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