ES351837A1 - Process for producing 2-carbalkoxyaminobenzimidazoles - Google Patents

Process for producing 2-carbalkoxyaminobenzimidazoles

Info

Publication number
ES351837A1
ES351837A1 ES351837A ES351837A ES351837A1 ES 351837 A1 ES351837 A1 ES 351837A1 ES 351837 A ES351837 A ES 351837A ES 351837 A ES351837 A ES 351837A ES 351837 A1 ES351837 A1 ES 351837A1
Authority
ES
Spain
Prior art keywords
formula
carbon atoms
bromine
defined above
carbalkoxyaminobenzimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES351837A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24504205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES351837(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES351837A1 publication Critical patent/ES351837A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing a 2-carbalkoxyaminobenzimidazole of formula ** (see formula) ** Wherein x is a lower alkyl of 3 to 5 carbon atoms or a lower alkoxy of 3 to 5 carbon atoms; and r is a lower alkyl of 1 to 4 carbon atoms, which consists of treating a compound of formula Ycn Wherein y is bromine or nhcoor, and r is as defined above, with an O-phenylenediamine of formula ** (see formula) ** Wherein x is as defined above, and, when y is bromine, heating the 2-aminobenzimidazole thus formed with an alkyl haloformate to obtain the product. (Machine-translation by Google Translate, not legally binding)
ES351837A 1967-03-22 1968-03-21 Process for producing 2-carbalkoxyaminobenzimidazoles Expired ES351837A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62500967A 1967-03-22 1967-03-22

Publications (1)

Publication Number Publication Date
ES351837A1 true ES351837A1 (en) 1969-12-01

Family

ID=24504205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES351837A Expired ES351837A1 (en) 1967-03-22 1968-03-21 Process for producing 2-carbalkoxyaminobenzimidazoles

Country Status (2)

Country Link
US (1) US3480642A (en)
ES (1) ES351837A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28403E (en) * 1964-08-04 1975-04-29 Butyl and n-propoxy-z-carbo- methoxyaminobenzimidazoles
US3682952A (en) * 1964-08-04 1972-08-08 Smith Kline French Lab 5(6)-n-butyl-2-carbomethoxy-benzimidazole
BE793358A (en) * 1971-12-27 1973-06-27 Hoechst Ag NEW 2-CARBALCOXY-AMINO-BENZIMIDAZOLE DERIVATIVES PRESENTING ANTHELMINTIC ACTIVITY AND THEIR PREPARATION PROCESS
IL43396A (en) * 1972-10-14 1976-07-30 Hoechst Ag Process for the preparation of 2-benzimidazole-carbamic acid alkyl and benzyl esters
US3993769A (en) * 1972-12-29 1976-11-23 Syntex (U.S.A.) Inc. 1,5(6)-Disubstituted benzimidazole-2-carbamate derivatives having anthelmintic activity
CA1032171A (en) * 1972-12-29 1978-05-30 Colin C. Beard 5(6)-benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US3929821A (en) * 1972-12-29 1975-12-30 Syntex Inc 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives
US3965113A (en) * 1972-12-29 1976-06-22 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US3969526A (en) * 1973-05-29 1976-07-13 Smithkline Corporation Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles
US4299837A (en) * 1979-12-05 1981-11-10 Montedison S.P.A. Anthelmintic benzimidazole-carbamates
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6506783B1 (en) * 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6608096B1 (en) * 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6462062B1 (en) * 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
MXPA03002601A (en) * 2000-09-26 2005-02-25 Univ Arizona Foundation Benzimidazoles and methods for use thereof in the treatment of cancer or viral infections.
WO2007014846A1 (en) * 2005-07-28 2007-02-08 Intervet International B.V. Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof
CN102283698B (en) * 2006-06-12 2016-02-24 史密夫和内修有限公司 For carrying out the guiding device of tibial resection
KR101403135B1 (en) 2006-06-14 2014-06-19 인터벳 인터내셔널 비.브이. A suspension comprising benzimidazole carbamate and a polysorbate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933502A (en) * 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US2933504A (en) * 1959-08-10 1960-04-19 Du Pont Derivatives of polyalkoxycarbonyl imine
US3010968A (en) * 1959-11-25 1961-11-28 Du Pont Process for manufacture of certain alkyl esters of benzimidazole carbamic acids

Also Published As

Publication number Publication date
US3480642A (en) 1969-11-25

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