ES351554A1 - Un procedimiento para la preparacion de productos acidos carboxilicos. - Google Patents
Un procedimiento para la preparacion de productos acidos carboxilicos.Info
- Publication number
- ES351554A1 ES351554A1 ES351554A ES351554A ES351554A1 ES 351554 A1 ES351554 A1 ES 351554A1 ES 351554 A ES351554 A ES 351554A ES 351554 A ES351554 A ES 351554A ES 351554 A1 ES351554 A1 ES 351554A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- alkyl
- prepared
- ester
- phenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 7
- 150000002148 esters Chemical class 0.000 abstract 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 230000003993 interaction Effects 0.000 abstract 3
- QWBBPBRQALCEIZ-UHFFFAOYSA-N 2,3-dimethylphenol Chemical compound CC1=CC=CC(O)=C1C QWBBPBRQALCEIZ-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229960000380 propiolactone Drugs 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- GEORDJYJYUGGSO-UHFFFAOYSA-N 2,3-dichloro-4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C(Cl)=C1Cl GEORDJYJYUGGSO-UHFFFAOYSA-N 0.000 abstract 1
- DDWHGAVRZXOOCZ-UHFFFAOYSA-N 2-[2,3-dichloro-4-(2-nitro-1-phenylsulfanylpropyl)phenoxy]acetyl chloride Chemical compound ClC1=C(OCC(=O)Cl)C=CC(=C1Cl)C(C(C)[N+](=O)[O-])SC1=CC=CC=C1 DDWHGAVRZXOOCZ-UHFFFAOYSA-N 0.000 abstract 1
- VPNIQOAWYIPOOJ-UHFFFAOYSA-N 3-(2,3-dichloro-4-formylphenoxy)propanoic acid Chemical compound OC(=O)CCOC1=CC=C(C=O)C(Cl)=C1Cl VPNIQOAWYIPOOJ-UHFFFAOYSA-N 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002262 Schiff base Substances 0.000 abstract 1
- 150000004753 Schiff bases Chemical class 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical class O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- ZECSUZBYOAVAIH-UHFFFAOYSA-N ethyl 2-(2,3-dimethylphenoxy)acetate Chemical compound CCOC(=O)COC1=CC=CC(C)=C1C ZECSUZBYOAVAIH-UHFFFAOYSA-N 0.000 abstract 1
- WAWVPKKLNWOVMH-UHFFFAOYSA-N ethyl 2-[4-(chloromethyl)-2,3-dimethylphenoxy]acetate Chemical compound C(C)OC(COC1=C(C(=C(C=C1)CCl)C)C)=O WAWVPKKLNWOVMH-UHFFFAOYSA-N 0.000 abstract 1
- PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000004312 hexamethylene tetramine Substances 0.000 abstract 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 125000004971 nitroalkyl group Chemical group 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- 230000000894 saliuretic effect Effects 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/008—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with tri- or tetrahalomethyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62533367A | 1967-03-23 | 1967-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES351554A1 true ES351554A1 (es) | 1969-12-01 |
Family
ID=24505578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES351554A Expired ES351554A1 (es) | 1967-03-23 | 1968-03-13 | Un procedimiento para la preparacion de productos acidos carboxilicos. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3507910A (en:Method) |
| BE (1) | BE712161A (en:Method) |
| ES (1) | ES351554A1 (en:Method) |
| FR (2) | FR1580893A (en:Method) |
| GB (1) | GB1191611A (en:Method) |
| NL (1) | NL6803254A (en:Method) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3409661A (en) * | 1965-09-30 | 1968-11-05 | Merck & Co Inc | Nuclear polysubstituted[(2-nitro-1-alkenyl)-aryloxy]alkanoic acids |
-
1967
- 1967-03-23 US US625333A patent/US3507910A/en not_active Expired - Lifetime
-
1968
- 1968-03-07 NL NL6803254A patent/NL6803254A/xx unknown
- 1968-03-13 ES ES351554A patent/ES351554A1/es not_active Expired
- 1968-03-14 BE BE712161D patent/BE712161A/xx unknown
- 1968-03-18 GB GB03075/68A patent/GB1191611A/en not_active Expired
- 1968-03-25 FR FR1580893D patent/FR1580893A/fr not_active Expired
- 1968-06-06 FR FR153941A patent/FR7895M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3507910A (en) | 1970-04-21 |
| GB1191611A (en) | 1970-05-13 |
| BE712161A (en:Method) | 1968-09-16 |
| FR1580893A (en:Method) | 1969-09-12 |
| FR7895M (en:Method) | 1970-05-04 |
| NL6803254A (en:Method) | 1968-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1291639A (en) | Xanthenyl alkanoic acid derivatives and pharmaceutical compositions containing them | |
| ES351554A1 (es) | Un procedimiento para la preparacion de productos acidos carboxilicos. | |
| GB1230630A (en:Method) | ||
| GB1479903A (en) | Substituted indanyl(oxy and thio)alkanoic acids and their derivatives | |
| ES380859A1 (es) | Un procedimiento para la preparacion de derivados de diben-zo-dioxocin. | |
| IE35599L (en) | 2-phenylbenzoxazoles. | |
| GB1237054A (en) | Derivatives of the 2-(lower alkyl)-3-(lower alkyl)-4-phenyl-3- or 4-cyclohexenecarboxylic acids | |
| ES440327A1 (es) | Procedimiento para la obtencion de cinnolina. | |
| GB1494773A (en) | Hydroxyphenylalkanoic acids and lactones thereof | |
| GB1473574A (en) | Sitosterol esters | |
| GB1382996A (en) | Substituted biphenyls | |
| GB1115135A (en) | Nitroalkenyl aryloxycarboxylic acids | |
| GB1138873A (en) | [(1-alkenylsulfonyl)-phenoxy] alkanoic acids and derivatives thereof | |
| US3514482A (en) | (3- and 4-(2-alkylidenealkanoyl)phenoxy)-fluoroacetic acids | |
| IL49124A (en) | D-homoandrosta-17a -carboxylic acids esters thereof their manufacture and pharmaceutical compositions containing them | |
| GB1377316A (en) | Dialkylaminoalkyl esters of arylaliphatic acids and acid addition salts thereof | |
| GB1461789A (en) | 3-substituted propanoic acid derivatives | |
| ES349014A1 (es) | Un procedimiento para la preparacion de acidos ariloxialca-noicos sustituidos. | |
| ES343389A1 (es) | Un procedimiento para la preparacion de acidos ariloxiace- ticos. | |
| GB1461788A (en) | Pharmacologically active cyclopentenyl propanoic acid derivative | |
| JPS5262237A (en) | Process for preparation of alpha-substituted phenylalkane carboxylic a cid | |
| JPS5283429A (en) | Preparation of aromatic unsaturated carboxylic acid amide derivatives | |
| ES449917A1 (es) | Un procedimiento para la preparacion de acidos (1-oxo-2-arilo tienil-2-sustituido-5-indaniloxi (o tio)) alcanoicos. | |
| GB1479264A (en) | 3-(5-aryl-2-furyl)-3-hydroxypropionic acids and ethyl esters thereof | |
| ES450125A1 (es) | Procedimiento para la preparacion de acidos -(6,11-dihidro- 11-oxodibenz (b,e) oxepin-2-il)-alcanoicos. |