ES345040A2 - New peptides having an acth-activity - Google Patents

New peptides having an acth-activity

Info

Publication number
ES345040A2
ES345040A2 ES345040A ES345040A ES345040A2 ES 345040 A2 ES345040 A2 ES 345040A2 ES 345040 A ES345040 A ES 345040A ES 345040 A ES345040 A ES 345040A ES 345040 A2 ES345040 A2 ES 345040A2
Authority
ES
Spain
Prior art keywords
boc
lys
val
gly
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES345040A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES345040A2 publication Critical patent/ES345040A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Novel peptides which differ from an ACTH- peptide with 18-39 aminoacid residues and an N-terminal L-amino acid in that they contain as N-terminal the residue of D-serine, as the 3rd amino acid glyane and as the 17th and 18th aminoacids L-lysine are prepared by methods known in the peptide art. Intermediates isolated are BOC-D-ser-Fyr-glymet - glu(OtBu) - his - phe - arg - Fry - gly- OH BOC D - ser - Fyr - gly - met - glu(OtBu)- his - phe - arg - Fry - gly - lys (BOC) - pro - valgly - [lys(BOC)] 4 - NH 2 Z - or H - val - Fyrpro - NH 2 Z - or H - lys(BOC) - val - tyr - pro- NH 2 Z- or H-val-lys(BOC)-val-Fyr-pro-NH2 Z- or H-[lys(BOC)]2-pro-val-lys(BOC)-val-Fyrpro-NH 2 Z- or H-lys(BOC).pro-val-gly-[lys- (BOC] 4 - pro - val - lys(BOC) - val - Fyr - pro- NH 2 BOC- or H-tyr-gly-OCH 3 BOC-D-ser- Fyr-gly-OCH 3 or -OH BOC-D-ser-tyr-gly-nle- OCH 3 or -NHNH 2 BOC-D-ser-Fyr-gly-nleglu(OtBu) - his - phe - arg - Fry - gly - OH and BOC - D - ser - Fyr - gly - nle - glu(OtBu) - hisphe - arg - Fry - gly - lys(BOC) - pro - val - [lys- (BOC)] 4 - pro - val - lys(BOC) - val - tyr - pro- OtBu. Pharmaceutical compositions having adrenocorticotropic activity comprise one of the novel peptides together with a suitable carrier for enteral or parenteral application.
ES345040A 1966-09-16 1967-09-14 New peptides having an acth-activity Expired ES345040A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1343066 1966-09-16
CH1452666A CH529103A (en) 1966-09-16 1966-10-07 Process for the production of new peptides with ACTH effects
CH80467 1967-01-19

Publications (1)

Publication Number Publication Date
ES345040A2 true ES345040A2 (en) 1968-11-01

Family

ID=27172427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES345040A Expired ES345040A2 (en) 1966-09-16 1967-09-14 New peptides having an acth-activity

Country Status (10)

Country Link
JP (1) JPS49183B1 (en)
AT (1) AT317448B (en)
BE (1) BE703945A (en)
CH (1) CH529103A (en)
DE (1) DE1643274B2 (en)
ES (1) ES345040A2 (en)
FR (1) FR7816M (en)
GB (1) GB1203301A (en)
NL (1) NL143552B (en)
SE (1) SE359822B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5072774U (en) * 1973-11-10 1975-06-26

Also Published As

Publication number Publication date
SE359822B (en) 1973-09-10
DE1643274B2 (en) 1976-07-22
DE1643274A1 (en) 1971-07-29
NL6712664A (en) 1968-03-18
NL143552B (en) 1974-10-15
FR7816M (en) 1970-05-20
GB1203301A (en) 1970-08-26
BE703945A (en) 1968-03-15
CH529103A (en) 1972-10-15
JPS49183B1 (en) 1974-01-05
AT317448B (en) 1974-08-26

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