ES341699A2 - Procedure for the obtaining of new piridil-dihidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of new piridil-dihidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES341699A2
ES341699A2 ES341699A ES341699A ES341699A2 ES 341699 A2 ES341699 A2 ES 341699A2 ES 341699 A ES341699 A ES 341699A ES 341699 A ES341699 A ES 341699A ES 341699 A2 ES341699 A2 ES 341699A2
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl group
translation
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES341699A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES341699A2 publication Critical patent/ES341699A2/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

IMPROVEMENTS INTRODUCED IN THE PURPOSE OF MAIN PATENT No. 324,465 for: "PROCEDURE FOR THE OBTAINING OF NEW PIRIDYL DIHYDROISOKINOLEINS of the general formula **(See formula)** in which the isoquinoline ring is attached at position 3 or 4 of the pyridine ring, and R1 represents an alkyl group containing from 1 to 5 carbon atoms or a benzyl group optionally substituted by a methyl group or a halogen atom, R2 represents an alkyl group with 1 to 5 carbon atoms or together with R1 and the adjacent carbon atom, a cycloalkane ring containing 5 or 6 carbon atoms, R3 represents a hydrogen or halogen atom or lower alkyl group and R4 and R5 which may be the same or different, represent hydrogen atoms or lower alkyl groups, as well as its addition salts with physiologically tolerable inorganic or organic acids, characterized by comprising the dehydrogenation of a tetrahydroisoquinoline of the general formula **(See formula)** where the symbols R1 to R5 have the meanings indicated above and the pyridine ring is linked in position 3 or 4 with the isoquinoline ring by means of a dehydrogenating agent or catalyst according to the classic procedures, and the eventual transformation of the compounds as well obtained in their addition salts with physiologically tolerable inorganic or organic acids. (Machine-translation by Google Translate, not legally binding)
ES341699A 1966-06-16 1967-06-12 Procedure for the obtaining of new piridil-dihidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding) Expired ES341699A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET0031378 1966-06-16

Publications (1)

Publication Number Publication Date
ES341699A2 true ES341699A2 (en) 1968-10-16

Family

ID=7556272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES341699A Expired ES341699A2 (en) 1966-06-16 1967-06-12 Procedure for the obtaining of new piridil-dihidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
CH (1) CH496717A (en)
DK (1) DK121859B (en)
ES (1) ES341699A2 (en)
SE (1) SE342226B (en)

Also Published As

Publication number Publication date
CH496717A (en) 1970-09-30
SE342226B (en) 1972-01-31
DK121859B (en) 1971-12-13

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