ES339991A1 - Method of preparation of hydroxy-cycle-hexane acids - 2-substitute carboxylics, its basic esters and salts that have a collete and antispastic activity. (Machine-translation by Google Translate, not legally binding) - Google Patents

Method of preparation of hydroxy-cycle-hexane acids - 2-substitute carboxylics, its basic esters and salts that have a collete and antispastic activity. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES339991A1
ES339991A1 ES339991A ES339991A ES339991A1 ES 339991 A1 ES339991 A1 ES 339991A1 ES 339991 A ES339991 A ES 339991A ES 339991 A ES339991 A ES 339991A ES 339991 A1 ES339991 A1 ES 339991A1
Authority
ES
Spain
Prior art keywords
see formula
hydroxy
translation
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES339991A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorio Guidotti SpA
Original Assignee
Laboratorio Guidotti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Guidotti SpA filed Critical Laboratorio Guidotti SpA
Publication of ES339991A1 publication Critical patent/ES339991A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Preparation method of 2-substituted hydroxy-cyclo-hexane-carboxylic acids, their basic esters and salts having a choleretic and antispastic activity, which respond to the general formula: **(See formula)** in which: a) when X = -COOR' **(See formula)** b) when X = -CH2-COOR' **(See formula)** characterized in that the acids that respond to the general formula: **(See formula)** in which: a) when X = -COOH, **(See formula)** b) when X = -CH2-COOR' **(See formula)** they are obtained by reacting 2-hydroxymethyl-cyclohexanone with a Grignard reagent, separating the resulting glycol and oxidizing the latter; or by reacting the ethyl ester of 2-cyclohexane acetic acid with a Grignard reagent and hydrolyzing the Α -lactone that has formed; or reducing 2-phenyl-2-hydroxy-cyclohexanecarboxylic acid under a hydrogen atmosphere under pressure in the presence of catalyst. (Machine-translation by Google Translate, not legally binding)
ES339991A 1966-04-29 1967-04-29 Method of preparation of hydroxy-cycle-hexane acids - 2-substitute carboxylics, its basic esters and salts that have a collete and antispastic activity. (Machine-translation by Google Translate, not legally binding) Expired ES339991A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1733566 1966-04-29

Publications (1)

Publication Number Publication Date
ES339991A1 true ES339991A1 (en) 1968-06-01

Family

ID=11150066

Family Applications (1)

Application Number Title Priority Date Filing Date
ES339991A Expired ES339991A1 (en) 1966-04-29 1967-04-29 Method of preparation of hydroxy-cycle-hexane acids - 2-substitute carboxylics, its basic esters and salts that have a collete and antispastic activity. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
BE (1) BE697771A (en)
DE (1) DE1618626C3 (en)
ES (1) ES339991A1 (en)
IL (1) IL27838A (en)
NL (1) NL154205B (en)
SE (2) SE328568B (en)

Also Published As

Publication number Publication date
DE1618626C3 (en) 1973-10-04
DE1618626B2 (en) 1973-02-22
SE328568B (en) 1970-09-21
BE697771A (en) 1967-10-02
NL6706059A (en) 1967-10-30
IL27838A (en) 1971-12-29
SE349295B (en) 1972-09-25
NL154205B (en) 1977-08-15
DE1618626A1 (en) 1971-01-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19880128