ES335760A1 - Procedimiento para la preparacion de derivados de la tiaze-pina. - Google Patents
Procedimiento para la preparacion de derivados de la tiaze-pina.Info
- Publication number
- ES335760A1 ES335760A1 ES335760A ES335760A ES335760A1 ES 335760 A1 ES335760 A1 ES 335760A1 ES 335760 A ES335760 A ES 335760A ES 335760 A ES335760 A ES 335760A ES 335760 A1 ES335760 A1 ES 335760A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- piperazino
- see formula
- halogen
- mean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000004912 thiazepines Chemical class 0.000 title abstract 2
- WJWDEWXJRCMLMU-UHFFFAOYSA-N benzo[b][1,4]benzoxazepin-6-amine Chemical class NC1=NC2=CC=CC=C2OC2=CC=CC=C12 WJWDEWXJRCMLMU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52089766A | 1966-01-17 | 1966-01-17 | |
| US52086566A | 1966-01-17 | 1966-01-17 | |
| US52084666A | 1966-01-17 | 1966-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES335760A1 true ES335760A1 (es) | 1968-03-16 |
Family
ID=27414773
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES335760A Expired ES335760A1 (es) | 1966-01-17 | 1967-01-17 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340821A Expired ES340821A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340820A Expired ES340820A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES340821A Expired ES340821A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340820A Expired ES340820A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3444169A (h) |
| JP (1) | JPS5141639B1 (h) |
| AT (1) | AT278805B (h) |
| BE (1) | BE692749A (h) |
| CH (3) | CH504459A (h) |
| DE (1) | DE1645954A1 (h) |
| ES (3) | ES335760A1 (h) |
| FR (2) | FR1508536A (h) |
| IL (2) | IL36894A (h) |
| NL (1) | NL6700663A (h) |
| SE (1) | SE344203B (h) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL140242B (nl) * | 1963-03-01 | 1973-11-15 | Wander Ag Dr A | Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen. |
| GB1192812A (en) * | 1966-05-20 | 1970-05-20 | American Cyanamid Co | 2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts |
| GB1265866A (h) * | 1968-08-23 | 1972-03-08 | ||
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| AU700078B2 (en) * | 1995-11-01 | 1998-12-17 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| US6890919B2 (en) * | 2001-06-26 | 2005-05-10 | Shitij Kapur | Atypical antipsychotic agents having low affinity for the D2 receptor |
| US7388954B2 (en) * | 2002-06-24 | 2008-06-17 | Freescale Semiconductor, Inc. | Method and apparatus for tone indication |
| US20060069083A1 (en) * | 2002-12-20 | 2006-03-30 | Gerd Steiner | Pesticidal dibenzo(hetero)azepine derivatives |
| JP2006515628A (ja) * | 2003-01-23 | 2006-06-01 | アカディア ファーマシューティカルズ，インコーポレーテッド | ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用 |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| PT1696931E (pt) * | 2003-12-22 | 2009-06-12 | Acadia Pharm Inc | Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas |
| JP2007536216A (ja) * | 2004-04-01 | 2007-12-13 | アカディア ファーマシューティカルズ，インコーポレーテッド | 固体ｎ−デスメチルクロザピンおよびその結晶形を合成および単離する方法 |
| US20070105819A1 (en) * | 2005-10-17 | 2007-05-10 | Roger Olsson | CB-1 modulating compounds and their use |
| US20080090805A1 (en) * | 2005-10-17 | 2008-04-17 | Acadia Pharmaceuticals Inc. | Cb-1 modulating compounds and their use |
| US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| TWI488854B (zh) * | 2008-06-20 | 2015-06-21 | Astrazeneca Ab | 二苯并噻氮呯衍生物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH384750A (de) * | 1960-06-08 | 1965-02-26 | Geigy Ag J R | Verfahren zur Herstellung von neuen 2,3 : 6,7-Diareno-1-oxa-4,5-diazepinen |
-
1966
- 1966-01-17 US US520865A patent/US3444169A/en not_active Expired - Lifetime
- 1966-01-17 AT AT00481/67A patent/AT278805B/de not_active IP Right Cessation
- 1966-12-25 IL IL36894A patent/IL36894A/en unknown
- 1966-12-25 IL IL27143A patent/IL27143A/en unknown
-
1967
- 1967-01-16 SE SE604/67A patent/SE344203B/xx unknown
- 1967-01-16 DE DE19671645954 patent/DE1645954A1/de active Pending
- 1967-01-16 NL NL6700663A patent/NL6700663A/xx unknown
- 1967-01-17 ES ES335760A patent/ES335760A1/es not_active Expired
- 1967-01-17 JP JP42003069A patent/JPS5141639B1/ja active Pending
- 1967-01-17 CH CH813070A patent/CH504459A/de not_active IP Right Cessation
- 1967-01-17 BE BE692749D patent/BE692749A/xx not_active IP Right Cessation
- 1967-01-17 FR FR91464A patent/FR1508536A/fr not_active Expired
- 1967-01-17 CH CH1505769A patent/CH495371A/de not_active IP Right Cessation
- 1967-01-17 CH CH60667A patent/CH504458A/de not_active IP Right Cessation
- 1967-04-14 FR FR102738A patent/FR6274M/fr not_active Expired
- 1967-05-22 ES ES340821A patent/ES340821A1/es not_active Expired
- 1967-05-22 ES ES340820A patent/ES340820A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES340821A1 (es) | 1968-09-16 |
| DE1645954A1 (de) | 1970-07-16 |
| CH504459A (de) | 1971-03-15 |
| FR1508536A (fr) | 1968-01-05 |
| CH504458A (de) | 1971-03-15 |
| IL36894A (en) | 1972-12-29 |
| CH495371A (de) | 1970-08-31 |
| AT278805B (de) | 1970-02-10 |
| FR6274M (h) | 1968-08-26 |
| US3444169A (en) | 1969-05-13 |
| ES340820A1 (es) | 1968-09-16 |
| JPS5141639B1 (h) | 1976-11-11 |
| BE692749A (h) | 1967-07-17 |
| NL6700663A (h) | 1967-07-18 |
| SE344203B (h) | 1972-04-04 |
| IL27143A (en) | 1972-01-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES335760A1 (es) | Procedimiento para la preparacion de derivados de la tiaze-pina. | |
| ES302622A1 (es) | Procedimiento para la preparacion de derivados heterociclicos. | |
| ES331339A1 (es) | Procedimiento para la preparacion de alquilenpiperidinas sustituidas. | |
| YU310580A (en) | Process for obtaining new benzothiazole derivatives | |
| GB1091734A (en) | Heterocyclic dyestuffs | |
| ES462685A1 (es) | Metodo de produccion de compuestos de rifamicina. | |
| ATE21700T1 (de) | Oxazinobenzothiazin-6,6-dioxidederivate, ihre herstellung und anwendung als arzneimittel. | |
| ES333487A1 (es) | Procedimiento para la preparacion de nuevos derivados de urea sustituidos. | |
| ES431804A1 (es) | Procedimiento para la preparacion de derivados acilatados de 2-aminotiazol. | |
| ES335761A1 (es) | Procedimiento para preparar 11-ter-aminobenz (b,f) (1,4) oxacepinas. | |
| ATE66226T1 (de) | Tetrahydro-beta-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| ES286808A1 (es) | Un procedimiento para la preparación de derivados de benzoxazepin | |
| IL59053A (en) | N-azolyl-acetanilides,their manufacture and their use as herbicides | |
| SE8205583D0 (sv) | New 5-aminosisoxazole derivatives and processes for producing the same | |
| GB1079489A (en) | Process for the production of 6,7-benzomorphanes | |
| ES298316A1 (es) | Procedimiento para la preparación de derivados de benzoxazepina | |
| ES328752A1 (es) | Procedimiento para la produccion de derivados de la benzodiacepin-8-ona. | |
| ES340867A1 (es) | Procedimiento para preparar 11-teraminodibenz-(b,f) (1,4) oxazepinas. | |
| ES361018A1 (es) | Procedimiento para la obtencion de sales de penicilinas biosinteticas y semisinteticas con derivados n-sustituidos del aminocetil-2-metoxifenol. | |
| ES367957A1 (es) | Un procedimiento para la preparacion de derivados de benzo-diacepina. | |
| ES360861A1 (es) | Procedimiento para la preparacion de nuevos derivados de tiazepina. | |
| ES335600A2 (es) | Procedimiento para la obtencion de derivados de la 5,6,7,9, 10,14b - hexahidroso-isoquinolo (2,1-d) benzo (1,4)-diacepin-6-ona. | |
| ES378410A1 (es) | Procedimiento de obtencion de sales de la alfa-aminobencil-penicilina. | |
| HUT44502A (en) | Process for producing 3-amino-dihydropyridine derivatives and pharmaceutical compositions containing them | |
| ES424221A2 (es) | Procedimiento de preparacion de nuevos oxazino (5,6,e) indoles sustituidos. |