ES332460A1 - A procedure for the preparation of des-a-androstan- (or pregnan) -onas and des-a-androst- (or pregn) -9-en-5-onas. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of des-a-androstan- (or pregnan) -onas and des-a-androst- (or pregn) -9-en-5-onas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES332460A1
ES332460A1 ES0332460A ES332460A ES332460A1 ES 332460 A1 ES332460 A1 ES 332460A1 ES 0332460 A ES0332460 A ES 0332460A ES 332460 A ES332460 A ES 332460A ES 332460 A1 ES332460 A1 ES 332460A1
Authority
ES
Spain
Prior art keywords
hydrogen
onas
des
hydroxyl
pregnan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0332460A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES332460A1 publication Critical patent/ES332460A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)

Abstract

A process for the preparation of desA-androstan- (or pregnan) -5-one and desA-androst- (or pregnan) -9-en-5-one, characterized by pyrolyzing a 5-oxo-3.5-dry-A acid -norandrostan-3-óic or 5-oxo-3,5-seco-A-norpregnan-3-óico of the formula **(See formula)** where I is hydrogen or a part group; X is hydrogen, lower alkyl, lower alkylthio, and lower alkanoylthio in position 6, or hydrogen, lower alkyl, lower alkylthio, lower alkanoylthio, and halogen in position 7; and Z represents a grouping of formulas Ia or Ib **(See formula)** where R1 is hydroxyl or lower alkanoyloxy; R2 is hydrogen or lower alkyl, while R1 and R2, taken together, are 17beta-0H, 17alpha-lower alkanoic acid lactone or oxo; R3 is hydrogen, lower alkyl, hydroxyl, or lower alkanoyloxy; R'3 is hydrogen, lower alkyl, fluorine, hydroxyl, or lower alkanoyloxy; R4 is hydrogen, lower alkyl, hydroxyl, or halogen; and R5 is hydrogen, hydroxyl or halogen, or an alkali metal salt of said acid, in the presence of a basic organic solvent. (Machine-translation by Google Translate, not legally binding)
ES0332460A 1965-10-20 1966-10-19 A procedure for the preparation of des-a-androstan- (or pregnan) -onas and des-a-androst- (or pregn) -9-en-5-onas. (Machine-translation by Google Translate, not legally binding) Expired ES332460A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49909465A 1965-10-20 1965-10-20

Publications (1)

Publication Number Publication Date
ES332460A1 true ES332460A1 (en) 1967-10-16

Family

ID=23983788

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0332460A Expired ES332460A1 (en) 1965-10-20 1966-10-19 A procedure for the preparation of des-a-androstan- (or pregnan) -onas and des-a-androst- (or pregn) -9-en-5-onas. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AT (1) AT268557B (en)
BE (1) BE688356A (en)
BR (1) BR6683708D0 (en)
CH (1) CH503682A (en)
DE (1) DE1568793A1 (en)
DK (1) DK123233B (en)
ES (1) ES332460A1 (en)
GB (1) GB1118335A (en)
IL (1) IL26664A (en)
NL (1) NL6614637A (en)
SE (1) SE330882B (en)

Also Published As

Publication number Publication date
SE330882B (en) 1970-12-07
IL26664A (en) 1970-09-17
GB1118335A (en) 1968-07-03
DK123233B (en) 1972-05-29
BE688356A (en) 1967-04-17
DE1568793A1 (en) 1970-07-09
CH503682A (en) 1971-02-28
NL6614637A (en) 1967-04-21
BR6683708D0 (en) 1973-12-26
AT268557B (en) 1969-02-10

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