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Pharmacia and Upjohn Co
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Upjohn Co
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Publication date
Priority claimed from US446396Aexternal-prioritypatent/US3380886A/en
Application filed by Upjohn CofiledCriticalUpjohn Co
Publication of ES325135A1publicationCriticalpatent/ES325135A1/en
Procedure for the production of steroids of the formula (III) ** (See formula) ** wherein R1 and R2 are selected from the group consisting of hydrogen and methyl; M is chosen from the group consisting of (see formula): (see formula) and (see formula) wherein A is selected from the group consisting of hydrogen, lower alkyl of 1 to 12 carbon atoms, inclusive, chloro, bromo and trifluoromethyl is selected from the group consisting of hydrogen, lower alkyl of 1 to 12 carbon atoms, carbon, inclusive, and Z is selected from the group consisting of hydrogen and the lower acyl radical of an organic carboxylic acid containing from 1 to 12 carbon atoms, inclusive, characterized in that it comprises (1) treating with a methyl halide. magnesium in the presence of a cuprous chloride catalyst a compound corresponding to formula (I) wherein R1, R2 and M have the same meaning as given above, (2) followed by treatment with an anhydride of an organic carboxylic acid containing from 1 to 12 carbon atoms, inclusive, to obtain a corresponding compound of the formula (II) ** (See formula) ** wherein Ac is the acyl radical of an organic carboxylic acid containing from 1 to 12 carbon atoms, inclusive, R1, R2 and M have the same meaning as given above and (3) treating a compound thus produced from the Formula II with sodium borohydride to obtain a corresponding compound of formula III, above. (Machine-translation by Google Translate, not legally binding)
ES0325135A1965-04-071966-04-05Procedure for the production of steroids. (Machine-translation by Google Translate, not legally binding)
ExpiredES325135A1
(en)