ES313667A1 - A procedure for the preparation of a medicine for the treatment of cardiovascular affections (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of a medicine for the treatment of cardiovascular affections (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES313667A1
ES313667A1 ES0313667A ES313667A ES313667A1 ES 313667 A1 ES313667 A1 ES 313667A1 ES 0313667 A ES0313667 A ES 0313667A ES 313667 A ES313667 A ES 313667A ES 313667 A1 ES313667 A1 ES 313667A1
Authority
ES
Spain
Prior art keywords
acetone
ajmaline
translation
treatment
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0313667A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dang R S R Et Canbonery R M
Original Assignee
Dang R S R Et Canbonery R M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dang R S R Et Canbonery R M filed Critical Dang R S R Et Canbonery R M
Publication of ES313667A1 publication Critical patent/ES313667A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method of preparing a medicament for the treatment of cardiovascular diseases, essentially characterized in that a reaction is determined in an organic solvent, preferably acetone, camphosulphonic acid on ajmaline base in stoichiometric amounts. The mixture brought to a gentle temperature (30 to 40%) is stirred until a limpid is obtained, then concentrated in a vacuum at a low temperature, until an accentuated consistency of syrup is achieved, adding then while stirring, a load of acetone and sealing. obtained, an equal volume of acetone is added, and the crystallized product, once drained, is washed with acetone and dried in a partial vacuum at a temperature lower than 30º C, the yield being approximately 95 per 100, with the camfosulfonate present of ajmaline, in the form of fine white crystals, with a tendency to take a slightly brown tint, if they are dried at a temperature above 30º C, these crystals being soluble in water, in methanol and ethanol, and in their anhydrous state their point of fusion is from 192 to 194ºC exerting the presence of the camfosulfºnico ion on ajmaline base, an important synergetic effect. (Machine-translation by Google Translate, not legally binding)
ES0313667A 1964-06-24 1965-06-01 A procedure for the preparation of a medicine for the treatment of cardiovascular affections (Machine-translation by Google Translate, not legally binding) Expired ES313667A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR979434A FR3479M (en) 1964-06-24 1964-06-24 Ajmaline camphosulfonate, a new drug which can be used in particular for the treatment of certain cardiovascular disorders.

Publications (1)

Publication Number Publication Date
ES313667A1 true ES313667A1 (en) 1967-03-01

Family

ID=8833082

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0313667A Expired ES313667A1 (en) 1964-06-24 1965-06-01 A procedure for the preparation of a medicine for the treatment of cardiovascular affections (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
DE (1) DE1545743A1 (en)
ES (1) ES313667A1 (en)
FR (1) FR3479M (en)

Also Published As

Publication number Publication date
FR3479M (en) 1965-08-09
DE1545743A1 (en) 1970-04-09

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