ES3041651T3 - Manufacturing of dimeric contrast agents - Google Patents

Manufacturing of dimeric contrast agents

Info

Publication number
ES3041651T3
ES3041651T3 ES22754878T ES22754878T ES3041651T3 ES 3041651 T3 ES3041651 T3 ES 3041651T3 ES 22754878 T ES22754878 T ES 22754878T ES 22754878 T ES22754878 T ES 22754878T ES 3041651 T3 ES3041651 T3 ES 3041651T3
Authority
ES
Spain
Prior art keywords
solution
formula
aqueous
compound
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES22754878T
Other languages
English (en)
Spanish (es)
Inventor
Andrea Banin
Andrea Barale
Valeria Boi
Sonia Gazzetto
Federica Buonsanti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Application granted granted Critical
Publication of ES3041651T3 publication Critical patent/ES3041651T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/122—Macromolecular compounds dimers of complexes or complex-forming compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES22754878T 2021-07-27 2022-07-26 Manufacturing of dimeric contrast agents Active ES3041651T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21187883 2021-07-27
PCT/EP2022/070901 WO2023006721A1 (en) 2021-07-27 2022-07-26 Manufacturing of dimeric contrast agents

Publications (1)

Publication Number Publication Date
ES3041651T3 true ES3041651T3 (en) 2025-11-13

Family

ID=77367218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES22754878T Active ES3041651T3 (en) 2021-07-27 2022-07-26 Manufacturing of dimeric contrast agents

Country Status (13)

Country Link
US (1) US12290576B2 (https=)
EP (1) EP4377323B1 (https=)
JP (1) JP7774081B2 (https=)
KR (1) KR20240034693A (https=)
CN (1) CN117412980A (https=)
AU (1) AU2022317221A1 (https=)
BR (1) BR112023022921A2 (https=)
CA (1) CA3216972A1 (https=)
ES (1) ES3041651T3 (https=)
IL (1) IL308888A (https=)
MX (1) MX2023014582A (https=)
PL (1) PL4377323T3 (https=)
WO (1) WO2023006721A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL4188912T3 (pl) * 2020-07-27 2024-11-18 Bracco Imaging Spa Wytwarzanie dimerycznych środków kontrastujących
CN117440959A (zh) * 2021-07-27 2024-01-23 伯拉考成像股份公司 用于制造钆络合物溶液的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
DE19849465A1 (de) 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
HRP20210061T1 (hr) 2015-12-10 2021-03-05 Bracco Imaging S.P.A Dimerna kontrastna sredstva
US12297180B2 (en) * 2019-12-13 2025-05-13 Bracco Imaging S.P.A. Manufacturing of protected DO3A

Also Published As

Publication number Publication date
KR20240034693A (ko) 2024-03-14
IL308888A (en) 2024-01-01
JP7774081B2 (ja) 2025-11-20
US20240269330A1 (en) 2024-08-15
CN117412980A (zh) 2024-01-16
EP4377323A1 (en) 2024-06-05
EP4377323B1 (en) 2025-07-02
WO2023006721A1 (en) 2023-02-02
JP2024527691A (ja) 2024-07-26
BR112023022921A2 (pt) 2024-02-27
US12290576B2 (en) 2025-05-06
EP4377323C0 (en) 2025-07-02
AU2022317221A1 (en) 2023-11-16
CA3216972A1 (en) 2023-02-02
PL4377323T3 (pl) 2025-12-01
MX2023014582A (es) 2023-12-13

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