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Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Priority to ES0302541ApriorityCriticalpatent/ES302541A1/en
Publication of ES302541A1publicationCriticalpatent/ES302541A1/en
Process for the preparation of levialiphatic acids, and especially for preparing a compound of formula ** (See formula) ** where R1 is an aromatic acyl radical with less than three welded rings; R2, a levyalkyl; R3 a radical selected from hydrogen and levyalkyl; R4, a radical selected from the group consisting of hydrogen, alkyl, alkylpyrrolidyl, alkylpiperidyl, alkylmorpholyl, alkylpiperacil and substituted aminoalkyl; and R5, a radical selected from the group consisting of hydrogen, levyalkyl, levialkoxy, simple or substituted amino and pyrrolidino; which comprises: 1, reducing a compound of formula ** (See formula) ** in an inert solvent, with Raney nickel and at a medium hydrogen pressure, at 25-120º C, until the equivalent amount of hydrogen is absorbed; 2nd, isolate the 2,3-hydroindolderivative thus obtained; 3, acylating said 2,3-dihydroindolderivative with an aromatic carboxylic acid chloride or anhydride of formula R 1 COOH, in an inert solvent and in the presence of a base; and 4th oxidation of the resulting N-substituted indolderivative with a mild oxidant, in an inert solvent. (Machine-translation by Google Translate, not legally binding)
ES0302541A1964-07-141964-07-14Procedure for the preparation of levialifatic acids. (Machine-translation by Google Translate, not legally binding)
ExpiredES302541A1
(en)
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