ES301159A1 - Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES301159A1
ES301159A1 ES0301159A ES301159A ES301159A1 ES 301159 A1 ES301159 A1 ES 301159A1 ES 0301159 A ES0301159 A ES 0301159A ES 301159 A ES301159 A ES 301159A ES 301159 A1 ES301159 A1 ES 301159A1
Authority
ES
Spain
Prior art keywords
group
formula
levyalkyl
translation
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0301159A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES301159A1 publication Critical patent/ES301159A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)

Abstract

Process for the preparation of dibenzocycloheptene derivatives, and especially for preparing compounds of formula ** (See formula) ** where R 'and R "are selected from the group consisting of simple levyalkyl radicals or linked together by an atom selected from carbon, nitrogen and oxygen, to form a heterocyclic ring selected from the group consisting of 1-piperidyl, 1-pyrrolidyl, -morpholinyl and 1-levialkyl-4-piperazinyl; RIV and RV are selected from the group consisting of hydrogen, aralkyl, alkyl and aryl; and X, X 'are selected from the group consisting of hydrogen, levyalkyl, levyalkenyl, halogen, trifluoromethyl, hydroxyl, levialkoxyl, mercapto, levialkylmercapto, levyalkylsulfonyl, sulfamoyl, levyalkylsulphamoyl and dilevialkylsulphamoyl; which comprises treating a compound of formula ** (See formula) ** where X, X ', RIV and RV have the above meanings, with a formula Grignard reagent (see formula) where Hal represents halogen, and R 'and R "are chosen from simple levyalkyl radicals or linked together by an atom selected from carbon, nitrogen and oxygen, to form a heterocyclic ring selected from the group consisting of 1-piperidyl , 1-pyrrolidyl, 4-morpholinyl and 1-levyalkyl-4-piperazinyl, in an organic solvent, and hydrolyze the resulting Grignard derivative. (Machine-translation by Google Translate, not legally binding)
ES0301159A 1963-06-11 1964-06-11 Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding) Expired ES301159A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28696263A 1963-06-11 1963-06-11
US30663963A 1963-09-04 1963-09-04

Publications (1)

Publication Number Publication Date
ES301159A1 true ES301159A1 (en) 1965-11-16

Family

ID=26964164

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0301159A Expired ES301159A1 (en) 1963-06-11 1964-06-11 Procedure for obtaining derivatives of dibenzocicloheptenes. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
BE (1) BE649168A (en)
CH (1) CH475236A (en)
CY (1) CY562A (en)
DE (1) DE1493987C3 (en)
DK (5) DK120759B (en)
ES (1) ES301159A1 (en)
FI (1) FI42321B (en)
FR (2) FR1563616A (en)
GB (1) GB1074081A (en)
IL (2) IL21455A (en)
NL (1) NL147935B (en)
NO (1) NO117079B (en)
SE (1) SE335989B (en)

Also Published As

Publication number Publication date
IL28487A (en) 1968-01-25
DK120759B (en) 1971-07-12
DE1493987B2 (en) 1973-03-01
GB1074081A (en) 1967-06-28
DK112731B (en) 1969-01-13
DE1493987A1 (en) 1969-07-24
DK115257B (en) 1969-09-22
FR1563616A (en) 1969-04-18
CY562A (en) 1970-10-14
NO117079B (en) 1969-06-30
SE335989B (en) 1971-06-21
NL6406641A (en) 1964-12-14
BE649168A (en) 1964-12-11
IL21455A (en) 1968-01-25
DK113015B (en) 1969-02-10
DE1493987C3 (en) 1973-09-27
FI42321B (en) 1970-03-31
NL147935B (en) 1975-12-15
DK115109B (en) 1969-09-08
CH475236A (en) 1969-07-15
FR3987M (en) 1966-03-07

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