ES2971091T3 - Un método para supervisar las respuestas farmacodinámicas mediadas por la administración de glucocorticoides in vivo - Google Patents

Un método para supervisar las respuestas farmacodinámicas mediadas por la administración de glucocorticoides in vivo Download PDF

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Publication number
ES2971091T3
ES2971091T3 ES18773895T ES18773895T ES2971091T3 ES 2971091 T3 ES2971091 T3 ES 2971091T3 ES 18773895 T ES18773895 T ES 18773895T ES 18773895 T ES18773895 T ES 18773895T ES 2971091 T3 ES2971091 T3 ES 2971091T3
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glucocorticoid
person
gene signature
administration
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ES18773895T
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English (en)
Spanish (es)
Inventor
Julie Carman
Yanhua Hu
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
ES18773895T 2017-08-30 2018-08-28 Un método para supervisar las respuestas farmacodinámicas mediadas por la administración de glucocorticoides in vivo Active ES2971091T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762551839P 2017-08-30 2017-08-30
PCT/US2018/048240 WO2019046233A1 (en) 2017-08-30 2018-08-28 METHOD FOR MONITORING PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO DELIVERY OF GLUCOCORTICOIDS

Publications (1)

Publication Number Publication Date
ES2971091T3 true ES2971091T3 (es) 2024-06-03

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ID=63678673

Family Applications (1)

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ES18773895T Active ES2971091T3 (es) 2017-08-30 2018-08-28 Un método para supervisar las respuestas farmacodinámicas mediadas por la administración de glucocorticoides in vivo

Country Status (7)

Country Link
US (1) US11421278B2 (enExample)
EP (1) EP3676402B1 (enExample)
JP (1) JP7288431B2 (enExample)
KR (1) KR102736851B1 (enExample)
CN (1) CN111051534B (enExample)
ES (1) ES2971091T3 (enExample)
WO (1) WO2019046233A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113990486B (zh) * 2021-10-27 2025-08-22 北京博富瑞医学检验实验室有限公司 一种基于aGVHD biomarker的一线糖皮质激素治疗反应预测模型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002332573A1 (en) 2001-08-17 2003-03-03 Incyte Genomics, Inc. Transporters and ion channels
US7384736B2 (en) * 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
CN1193761C (zh) * 2003-06-25 2005-03-23 暨南大学 一种糖皮质激素的可控释放体系及其制备方法
SE0401032D0 (sv) * 2004-04-22 2004-04-22 Duocort Ab A new acute glucocorticoid therapy
AU2005281352B2 (en) * 2004-09-09 2011-01-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal compositions of glucocorticoid and glucocorticoid derivatives
CN103533943B (zh) 2010-11-10 2018-02-13 安进研发(慕尼黑)股份有限公司 由cd3特异性结合结构域导致的不良作用的预防
WO2013082288A1 (en) * 2011-11-29 2013-06-06 The Regents Of The University Of California Glucorticoid receptor gene nr3c1 methylation in irritable bowel syndrome and other stress disorders

Also Published As

Publication number Publication date
WO2019046233A1 (en) 2019-03-07
US11421278B2 (en) 2022-08-23
US20200299770A1 (en) 2020-09-24
CN111051534A (zh) 2020-04-21
JP2020532302A (ja) 2020-11-12
EP3676402A1 (en) 2020-07-08
KR20200040872A (ko) 2020-04-20
JP7288431B2 (ja) 2023-06-07
EP3676402B1 (en) 2023-12-27
KR102736851B1 (ko) 2024-11-29
CN111051534B (zh) 2025-05-30

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