CN111051534B - 监测体内施用糖皮质激素介导的药效学反应的方法 - Google Patents

监测体内施用糖皮质激素介导的药效学反应的方法 Download PDF

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CN111051534B
CN111051534B CN201880056618.6A CN201880056618A CN111051534B CN 111051534 B CN111051534 B CN 111051534B CN 201880056618 A CN201880056618 A CN 201880056618A CN 111051534 B CN111051534 B CN 111051534B
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glucocorticoid
gene signature
gene
human
signature score
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CN111051534A (zh
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J·卡曼
Y·胡
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Bristol Myers Squibb Co
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201880056618.6A 2017-08-30 2018-08-28 监测体内施用糖皮质激素介导的药效学反应的方法 Active CN111051534B (zh)

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US201762551839P 2017-08-30 2017-08-30
US62/551,839 2017-08-30
PCT/US2018/048240 WO2019046233A1 (en) 2017-08-30 2018-08-28 METHOD FOR MONITORING PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO DELIVERY OF GLUCOCORTICOIDS

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CN111051534B true CN111051534B (zh) 2025-05-30

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US (1) US11421278B2 (enExample)
EP (1) EP3676402B1 (enExample)
JP (1) JP7288431B2 (enExample)
KR (1) KR102736851B1 (enExample)
CN (1) CN111051534B (enExample)
ES (1) ES2971091T3 (enExample)
WO (1) WO2019046233A1 (enExample)

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CN113990486B (zh) * 2021-10-27 2025-08-22 北京博富瑞医学检验实验室有限公司 一种基于aGVHD biomarker的一线糖皮质激素治疗反应预测模型

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1942193A (zh) * 2004-04-22 2007-04-04 杜奥科特公司 用于紧急糖皮质激素治疗的药物组合物
CN101048138A (zh) * 2004-09-09 2007-10-03 耶路撒冷希伯来大学伊萨姆研发公司 脂质体糖皮质激素用于治疗炎性状态的用途

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
AU2002332573A1 (en) * 2001-08-17 2003-03-03 Incyte Genomics, Inc. Transporters and ion channels
US7384736B2 (en) * 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
CN1193761C (zh) * 2003-06-25 2005-03-23 暨南大学 一种糖皮质激素的可控释放体系及其制备方法
SMT201700250T1 (it) * 2010-11-10 2017-07-18 Amgen Res Munich Gmbh Prevenzione di effetti avversi provocati da domini leganti cd3 specifici
WO2013082288A1 (en) * 2011-11-29 2013-06-06 The Regents Of The University Of California Glucorticoid receptor gene nr3c1 methylation in irritable bowel syndrome and other stress disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1942193A (zh) * 2004-04-22 2007-04-04 杜奥科特公司 用于紧急糖皮质激素治疗的药物组合物
CN101048138A (zh) * 2004-09-09 2007-10-03 耶路撒冷希伯来大学伊萨姆研发公司 脂质体糖皮质激素用于治疗炎性状态的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gene Signature for Glucocorticoid, from in Vitro to In Vivo;Hu 等;Arthritis & Rheumatology;第68卷;第1页研究目的-结论部分 *
Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells;Wim J E Tissing等;Blood;第109卷(第9期);摘要、表1 *

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US11421278B2 (en) 2022-08-23
WO2019046233A1 (en) 2019-03-07
KR102736851B1 (ko) 2024-11-29
EP3676402A1 (en) 2020-07-08
KR20200040872A (ko) 2020-04-20
JP7288431B2 (ja) 2023-06-07
EP3676402B1 (en) 2023-12-27
US20200299770A1 (en) 2020-09-24
CN111051534A (zh) 2020-04-21
ES2971091T3 (es) 2024-06-03
JP2020532302A (ja) 2020-11-12

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