ES2932354T3 - Dinucleótidos cíclicos como agentes anticáncer - Google Patents
Dinucleótidos cíclicos como agentes anticáncer Download PDFInfo
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- ES2932354T3 ES2932354T3 ES18752985T ES18752985T ES2932354T3 ES 2932354 T3 ES2932354 T3 ES 2932354T3 ES 18752985 T ES18752985 T ES 18752985T ES 18752985 T ES18752985 T ES 18752985T ES 2932354 T3 ES2932354 T3 ES 2932354T3
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762538329P | 2017-07-28 | 2017-07-28 | |
| PCT/US2018/043907 WO2019023459A1 (en) | 2017-07-28 | 2018-07-26 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2932354T3 true ES2932354T3 (es) | 2023-01-18 |
Family
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|---|---|---|---|
| ES18752985T Active ES2932354T3 (es) | 2017-07-28 | 2018-07-26 | Dinucleótidos cíclicos como agentes anticáncer |
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| US (1) | US10744150B2 (enExample) |
| EP (1) | EP3658565B1 (enExample) |
| JP (1) | JP7186764B2 (enExample) |
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| CN (1) | CN110997691B (enExample) |
| AR (1) | AR112290A1 (enExample) |
| ES (1) | ES2932354T3 (enExample) |
| TW (1) | TW201909903A (enExample) |
| WO (1) | WO2019023459A1 (enExample) |
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| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| SG11202008827XA (en) | 2018-04-13 | 2020-10-29 | Bristol Myers Squibb Co | Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds |
| CN110818714A (zh) * | 2018-08-14 | 2020-02-21 | 连云港润众制药有限公司 | 一种恩替卡韦中间体的合成方法 |
| US11161864B2 (en) | 2018-10-29 | 2021-11-02 | Venenum Biodesign, LLC | Sting agonists |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| US12421268B2 (en) | 2019-04-16 | 2025-09-23 | Roche Innovation Center Copenhagen A/S | Process for preparing nucleotide P(V) monomers |
| JP7621974B2 (ja) | 2019-05-09 | 2025-01-27 | アリゴス セラピューティクス インコーポレイテッド | Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物 |
| WO2021013234A1 (en) | 2019-07-25 | 2021-01-28 | Beigene, Ltd. | Cyclic dinucleotides as sting agonists |
| CN110684062B (zh) * | 2019-10-18 | 2022-12-13 | 大连大学 | 一种治疗非小细胞肺癌的药物及其制备方法 |
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| CN119930724B (zh) * | 2024-12-18 | 2025-10-28 | 湖南大学 | 一种诱导激活的自递送环二核苷衍生物及其制备方法与用于抗肿瘤免疫治疗的用途 |
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2018
- 2018-07-26 KR KR1020207005451A patent/KR102709265B1/ko active Active
- 2018-07-26 CN CN201880049466.7A patent/CN110997691B/zh active Active
- 2018-07-26 EP EP18752985.4A patent/EP3658565B1/en active Active
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- 2018-07-27 TW TW107126128A patent/TW201909903A/zh unknown
- 2018-07-27 US US16/047,071 patent/US10744150B2/en active Active
- 2018-07-27 AR ARP180102134 patent/AR112290A1/es unknown
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| JP7186764B2 (ja) | 2022-12-09 |
| KR102709265B1 (ko) | 2024-09-23 |
| WO2019023459A1 (en) | 2019-01-31 |
| JP2020529400A (ja) | 2020-10-08 |
| TW201909903A (zh) | 2019-03-16 |
| KR20200032180A (ko) | 2020-03-25 |
| AR112290A1 (es) | 2019-10-09 |
| EP3658565B1 (en) | 2022-11-09 |
| CN110997691A (zh) | 2020-04-10 |
| US10744150B2 (en) | 2020-08-18 |
| EP3658565A1 (en) | 2020-06-03 |
| CN110997691B (zh) | 2023-11-07 |
| US20190030057A1 (en) | 2019-01-31 |
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