ES2864681T3 - Tratamiento del cáncer hematológico refractario a un agente contra el cáncer - Google Patents
Tratamiento del cáncer hematológico refractario a un agente contra el cáncer Download PDFInfo
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- ES2864681T3 ES2864681T3 ES13860034T ES13860034T ES2864681T3 ES 2864681 T3 ES2864681 T3 ES 2864681T3 ES 13860034 T ES13860034 T ES 13860034T ES 13860034 T ES13860034 T ES 13860034T ES 2864681 T3 ES2864681 T3 ES 2864681T3
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| US201261734933P | 2012-12-07 | 2012-12-07 | |
| US201361826973P | 2013-05-23 | 2013-05-23 | |
| PCT/US2013/073667 WO2014089483A1 (en) | 2012-12-07 | 2013-12-06 | Methods and compositions for treatment of cancer |
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| EP3004387A4 (en) * | 2013-05-31 | 2017-04-12 | Onconova Therapeutics, Inc. | Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders |
| US11382877B2 (en) | 2017-04-13 | 2022-07-12 | Onconova Therapeutics, Inc. | Formulation of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone with enhanced stability and bioavailability |
| US12156856B2 (en) * | 2017-04-13 | 2024-12-03 | Traws Pharma, Inc. | Formulation of (e)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone with enhanced stability and bioavailability |
| AR109503A1 (es) * | 2017-04-13 | 2018-12-19 | Onconova Therapeutics Inc | Composición farmacéutica que comprende (e)-2,4,6-trimetoxiestiril-3-[(carboximetil)amino]-4-metoxibencilsulfona, forma de dosificación oral y método de tratamiento |
| CA3228644A1 (en) * | 2021-08-12 | 2023-02-16 | Onconova Therapeutics, Inc. | Methods and compositions for treating cancer |
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| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| CN1163480C (zh) | 1997-10-03 | 2004-08-25 | 坦普尔大学 | 苯乙烯砜抗癌剂 |
| US6201154B1 (en) | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| US6541475B2 (en) | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| US6486210B2 (en) | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| AU2001296677A1 (en) | 2000-10-05 | 2002-04-15 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| JP2004521126A (ja) | 2001-02-27 | 2004-07-15 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｚ）−スチリルベンジルスルホン及びそれらの医薬としての使用 |
| NZ535232A (en) | 2002-02-28 | 2007-05-31 | Univ Temple | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
| JP4982364B2 (ja) | 2004-07-19 | 2012-07-25 | オンコノバ セラピューティクス インコーポレイテッド | （ｅ）−２，６−ジアルキルオキシスチリル４−置換ベンジルスルフォン非経口用投与用製剤 |
| US8476320B2 (en) | 2007-01-16 | 2013-07-02 | Onconova Therapeutics, Inc | Formulations for parenteral administration of amino-substituted (E)-2, 6-dialkoxystyryl 4-substituted benzylsulfones |
| KR101707669B1 (ko) * | 2008-04-17 | 2017-02-16 | 더 존스 홉킨스 유니버시티 | 약제-내성 종양에서 화학요법제 활성을 증강시키는 ｏｎ01910.ｎａ |
| CN102438588B (zh) * | 2009-03-23 | 2015-04-01 | 埃姆比特生物科学公司 | 使用联合治疗法治疗疾病的方法 |
| US20140120083A1 (en) * | 2012-11-01 | 2014-05-01 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
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| EP2928456A1 (en) | 2015-10-14 |
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| WO2014089483A1 (en) | 2014-06-12 |
| EP2928456A4 (en) | 2016-08-24 |
| US20150313859A1 (en) | 2015-11-05 |
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