ES286056A1 - Procedure for the manufacture of soluble derivatives in water of the compounds of the tetraciclino group (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the manufacture of soluble derivatives in water of the compounds of the tetraciclino group (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES286056A1 ES286056A1 ES286056A ES286056A ES286056A1 ES 286056 A1 ES286056 A1 ES 286056A1 ES 286056 A ES286056 A ES 286056A ES 286056 A ES286056 A ES 286056A ES 286056 A1 ES286056 A1 ES 286056A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- compounds
- translation
- manufacture
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Process for the manufacture of water-soluble derivatives of the compounds of the tetracycline group, carried out in the presence of formaldehyde, characterized in that the antibiotic, which may be present in an amphoteric form or as a salt with both a base and an acid, may be reacting in a temperature range between 20 to 100º C with a pH between 4 and 9, using as a reaction medium a solvent or a mixture of solvents, which can dissolve the product of the reaction or one of its salts and then allow the isolation of the product, which can be taken into account as solvents of the group of ethers, such as dioxane or tetrahydrofuran, or halogen derivatives such as chloroform, methyl chloride or ethyl-chlorohydrin, in addition aromatic compounds such as benzol or toluene or aliphatic alcohols with C1 to C4 or dimethylformamide . (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304562A CH444847A (en) | 1962-03-15 | 1962-03-15 | Process for the preparation of water-soluble derivatives of the tetracyclines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES286056A1 true ES286056A1 (en) | 1963-10-16 |
Family
ID=4247371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES286056A Expired ES286056A1 (en) | 1962-03-15 | 1963-03-14 | Procedure for the manufacture of soluble derivatives in water of the compounds of the tetraciclino group (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT249264B (en) |
| CH (1) | CH444847A (en) |
| DK (1) | DK123522B (en) |
| ES (1) | ES286056A1 (en) |
| FR (1) | FR1558902A (en) |
| GB (1) | GB994718A (en) |
| NO (1) | NO117853B (en) |
| SE (1) | SE327397B (en) |
-
1962
- 1962-03-15 CH CH304562A patent/CH444847A/en unknown
-
1963
- 1963-03-05 AT AT172163A patent/AT249264B/en active
- 1963-03-06 DK DK102263A patent/DK123522B/en unknown
- 1963-03-07 SE SE252763A patent/SE327397B/xx unknown
- 1963-03-14 GB GB1021063A patent/GB994718A/en not_active Expired
- 1963-03-14 NO NO14788863A patent/NO117853B/no unknown
- 1963-03-14 FR FR1558902D patent/FR1558902A/fr not_active Expired
- 1963-03-14 ES ES286056A patent/ES286056A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1558902A (en) | 1969-03-07 |
| AT249264B (en) | 1966-09-12 |
| GB994718A (en) | 1965-06-10 |
| CH444847A (en) | 1967-10-15 |
| SE327397B (en) | 1970-08-24 |
| DK123522B (en) | 1972-07-03 |
| NO117853B (en) | 1969-10-06 |
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