ES2856173T3 - Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar - Google Patents

Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar Download PDF

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Publication number
ES2856173T3
ES2856173T3 ES12779354T ES12779354T ES2856173T3 ES 2856173 T3 ES2856173 T3 ES 2856173T3 ES 12779354 T ES12779354 T ES 12779354T ES 12779354 T ES12779354 T ES 12779354T ES 2856173 T3 ES2856173 T3 ES 2856173T3
Authority
ES
Spain
Prior art keywords
compound
arterial hypertension
pulmonary arterial
pulmonary
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12779354T
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English (en)
Spanish (es)
Inventor
Edda Spiekerkoetter
Marlene Rabinovitch
Philip Beachy
David Solow-Cordero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2856173T3 publication Critical patent/ES2856173T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES12779354T 2011-05-02 2012-04-30 Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar Active ES2856173T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161481317P 2011-05-02 2011-05-02
PCT/US2012/035793 WO2012151153A1 (en) 2011-05-02 2012-04-30 Use of fk506 for the treatment of pulmonary arterial hypertension

Publications (1)

Publication Number Publication Date
ES2856173T3 true ES2856173T3 (es) 2021-09-27

Family

ID=47108011

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12779354T Active ES2856173T3 (es) 2011-05-02 2012-04-30 Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar
ES20211109T Active ES2954905T3 (es) 2011-05-02 2012-04-30 Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES20211109T Active ES2954905T3 (es) 2011-05-02 2012-04-30 Uso de FK506 para el tratamiento de la hipertensión arterial pulmonar

Country Status (19)

Country Link
US (6) US9474745B2 (cg-RX-API-DMAC7.html)
EP (3) EP3821891B1 (cg-RX-API-DMAC7.html)
JP (1) JP6177765B2 (cg-RX-API-DMAC7.html)
AU (2) AU2012250974B9 (cg-RX-API-DMAC7.html)
CA (1) CA2834368C (cg-RX-API-DMAC7.html)
CY (1) CY1123900T1 (cg-RX-API-DMAC7.html)
DK (2) DK2704711T3 (cg-RX-API-DMAC7.html)
ES (2) ES2856173T3 (cg-RX-API-DMAC7.html)
FI (1) FI3821891T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20210245T1 (cg-RX-API-DMAC7.html)
HU (1) HUE053229T2 (cg-RX-API-DMAC7.html)
LT (1) LT2704711T (cg-RX-API-DMAC7.html)
PL (1) PL2704711T3 (cg-RX-API-DMAC7.html)
PT (2) PT3821891T (cg-RX-API-DMAC7.html)
RS (1) RS61480B1 (cg-RX-API-DMAC7.html)
SI (1) SI2704711T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202100085T1 (cg-RX-API-DMAC7.html)
WO (1) WO2012151153A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201307905B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180325875A1 (en) * 2015-01-13 2018-11-15 Vivus, Inc. Combination therapy for pulmonary hypertension
EP3294294A4 (en) * 2015-05-08 2019-01-02 Vivus, Inc. Compositions and methods for the treatment or prevention of pulmonary hypertension
CN105062976B (zh) * 2015-08-05 2018-05-11 中国医学科学院基础医学研究所 肺动脉高压治疗药物的干细胞筛选模型及应用
ES2683921B1 (es) * 2017-03-28 2019-04-22 Univ Vigo Método para la determinación del pronóstico en sujetos diagnosticados con hipertensión arterial pulmonar
US11413280B2 (en) 2017-05-19 2022-08-16 The Board Of Trustees Of The Leland Stanford Junior University Enzastaurin and fragile histidine triad (FHIT)-increasing agents for the treatment of pulmonary hypertension
US12440479B2 (en) 2018-03-28 2025-10-14 Georg-August-Universitaet Goettingen, Stiftung Oeffentlichen Rechts, Universitaetsmedizin Prevention or treatment of chronic organ injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489335B2 (en) 2000-02-18 2002-12-03 Gholam A. Peyman Treatment of ocular disease
US20050119330A1 (en) 2003-03-17 2005-06-02 Kao Peter N. Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
WO2007112052A2 (en) 2006-03-23 2007-10-04 Macusight, Inc. Formulations and methods for vascular permeability-related diseases or conditions
FR2936060B1 (fr) * 2008-09-17 2010-11-19 Assist Publ Hopitaux De Paris Procede de diagnostic d'une sclerodermie systemique ou d'une hypertension arterielle pulmonaire.
MX2011004284A (es) * 2008-10-22 2011-06-21 Sam Amer & Co Inc Metodo para tratar la hipertension arterial pulmonar.

Also Published As

Publication number Publication date
HRP20210245T1 (hr) 2021-04-02
PT3821891T (pt) 2023-08-31
US20140135358A1 (en) 2014-05-15
EP2704711A4 (en) 2014-11-19
PL2704711T3 (pl) 2021-07-05
PT2704711T (pt) 2021-03-02
HUE053229T2 (hu) 2021-06-28
US20230404982A1 (en) 2023-12-21
AU2012250974B9 (en) 2017-05-18
EP3821891A1 (en) 2021-05-19
US20220184042A1 (en) 2022-06-16
AU2012250974B2 (en) 2017-05-04
CA2834368A1 (en) 2012-11-08
US20190091208A1 (en) 2019-03-28
JP6177765B2 (ja) 2017-08-09
CA2834368C (en) 2020-02-18
EP3821891B1 (en) 2023-06-07
EP4279130A2 (en) 2023-11-22
EP4279130A3 (en) 2024-02-21
AU2012250974A1 (en) 2013-11-14
SMT202100085T1 (it) 2021-05-07
AU2017210583A1 (en) 2017-08-24
ZA201307905B (en) 2015-05-27
WO2012151153A1 (en) 2012-11-08
FI3821891T3 (fi) 2023-08-24
JP2014513121A (ja) 2014-05-29
EP2704711A1 (en) 2014-03-12
ES2954905T3 (es) 2023-11-27
DK2704711T3 (da) 2021-02-22
US20170007585A1 (en) 2017-01-12
AU2017210583B2 (en) 2019-02-07
LT2704711T (lt) 2021-04-26
DK3821891T3 (da) 2023-09-04
CY1123900T1 (el) 2022-05-27
EP2704711B1 (en) 2020-12-02
RS61480B1 (sr) 2021-03-31
SI2704711T1 (sl) 2021-04-30
US20180185340A1 (en) 2018-07-05
US9474745B2 (en) 2016-10-25

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