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Merck KGaA
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E Merck AG
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Publication of ES285014A1publicationCriticalpatent/ES285014A1/en
Process for the preparation of 3-methylenesteroids, of the formula I ** (See formula) ** in which R1 means hydrogen or methyl, R2 means hydrogen or the group R4CO-, R3 means hydrogen, methyl or ethyl, and R4 means an aliphatic, cycloaliphatic, olefinic, aromatic or araliphatic hydrocarbon radical having 1 to 12 carbon atoms, characterized in that a 3-keto-steroid of the formula II is reacted ** (See formula) ** in which R1, R2 and R3 have the indicated significance for formula I, under the conditions of a Wittig reaction with a triarylphosphinmethylene of the formula Ar1Ar2Ar3P = CH2 in which Ar1, Ar2 and Ar3 mean phenyl or substituted phenyl radicals the same or different, or why a 17-keto-steroid of the formula III is reacted ** (See formula) ** in which R1 means hydrogen or methyl, with an organo-metallic reactant of the formula ** (See formula) ** in which R3 means methyl or ethyl, And it means a lithium atom or the group -MGX, and X means a chlorine, bromine or iodine atom, and in that a compound of the formula I, in which R 2 is hydrogen, is optionally esterified with an organic carbonic acid or a derivative of one of said carbonic acids, suitable for esterification. (Machine-translation by Google Translate, not legally binding)
ES0285014A1962-02-101963-02-09Procedure for the preparation of 3-methylene-steroids (Machine-translation by Google Translate, not legally binding)
ExpiredES285014A1
(en)
Procedure for the preparation of new derivatives of d treo - 1 - phenyl - 2 - amino - 1,3 - propandiol. (Machine-translation by Google Translate, not legally binding)