ES2768649T3 - Preparaciones para tratar un cáncer positivo para GD2 - Google Patents

Preparaciones para tratar un cáncer positivo para GD2 Download PDF

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Publication number
ES2768649T3
ES2768649T3 ES14802642T ES14802642T ES2768649T3 ES 2768649 T3 ES2768649 T3 ES 2768649T3 ES 14802642 T ES14802642 T ES 14802642T ES 14802642 T ES14802642 T ES 14802642T ES 2768649 T3 ES2768649 T3 ES 2768649T3
Authority
ES
Spain
Prior art keywords
treatment
antibody
patient
preparation
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14802642T
Other languages
English (en)
Spanish (es)
Inventor
Hans Loibner
Oliver Mutschlechner
Ruth Ladenstein
Isabel Klier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apeiron Biologics GmbH
Original Assignee
Apeiron Biologics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP13193953.0A external-priority patent/EP2875827A1/en
Priority claimed from CA2834000A external-priority patent/CA2834000A1/en
Priority claimed from US14/182,776 external-priority patent/US10294305B2/en
Application filed by Apeiron Biologics GmbH filed Critical Apeiron Biologics GmbH
Application granted granted Critical
Publication of ES2768649T3 publication Critical patent/ES2768649T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES14802642T 2013-11-21 2014-11-21 Preparaciones para tratar un cáncer positivo para GD2 Active ES2768649T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201314086696A 2013-11-21 2013-11-21
EP13193953.0A EP2875827A1 (en) 2013-11-21 2013-11-21 Preparations and methods for treating a GD2 positive cancer
CA2834000A CA2834000A1 (en) 2013-11-21 2013-11-21 Method for treating a gd2 positive cancer
US14/182,776 US10294305B2 (en) 2012-06-18 2014-02-18 Method for treating a GD2 positive cancer
PCT/EP2014/075315 WO2015075194A1 (en) 2013-11-21 2014-11-21 Preparations and methods for treating a gd2 positive cancer

Publications (1)

Publication Number Publication Date
ES2768649T3 true ES2768649T3 (es) 2020-06-23

Family

ID=53179006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14802642T Active ES2768649T3 (es) 2013-11-21 2014-11-21 Preparaciones para tratar un cáncer positivo para GD2

Country Status (19)

Country Link
US (3) US10995147B2 (enExample)
EP (2) EP3620173A1 (enExample)
JP (2) JP6693873B2 (enExample)
AU (2) AU2014351796B2 (enExample)
CA (1) CA2930285A1 (enExample)
CY (1) CY1122508T1 (enExample)
DK (1) DK3071220T3 (enExample)
EA (1) EA201691055A1 (enExample)
ES (1) ES2768649T3 (enExample)
HR (1) HRP20200128T1 (enExample)
HU (1) HUE047920T2 (enExample)
LT (1) LT3071220T (enExample)
NZ (1) NZ720273A (enExample)
PL (1) PL3071220T3 (enExample)
PT (1) PT3071220T (enExample)
RS (1) RS59817B1 (enExample)
SI (1) SI3071220T1 (enExample)
SM (1) SMT202000027T1 (enExample)
WO (1) WO2015075194A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013189516A1 (en) 2012-06-18 2013-12-27 Apeiron Biologics Ag Method for treating a gd2 positive cancer
EA201691055A1 (ru) 2013-11-21 2016-11-30 Апейрон Биолоджикс Аг Препараты и способы лечения gd2-положительного рака
US9840566B2 (en) 2013-11-21 2017-12-12 Apeiron Biologics Ag Preparations and methods for treating a GD2 positive cancer
RU2663104C1 (ru) * 2017-07-13 2018-08-01 Общество с ограниченной ответственностью "Реал Таргет" Получение пегилированных фрагментов gd2-специфичных антител, индуцирующих прямую клеточную гибель gd2-позитивных опухолевых клеток, и их применение в терапии gd2-позитивных опухолей
JP2020534370A (ja) * 2017-09-21 2020-11-26 ユーエムセー ユトレヒト ホールディング ベイフェイＵＭＣ Ｕｔｒｅｃｈｔ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． 神経芽腫の治療のための抗ｇｄ２抗体
JP2023532753A (ja) * 2020-07-06 2023-07-31 イーユーエスエー ファーマ （ユーケー） リミテッド Ｇｄ２陽性がんを治療するための方法
WO2026053122A1 (en) * 2024-09-04 2026-03-12 Dana-Farber Cancer Institute, Inc. Methods of treating retinoid responsive cancers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863713A (en) 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
EP1345968A2 (en) 2000-12-28 2003-09-24 Altus Biologics Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
US7455833B2 (en) 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
ATE471946T1 (de) 2002-12-17 2010-07-15 Merck Patent Gmbh Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
CA2553883C (en) 2004-01-22 2013-04-02 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-cancer antibodies with reduced complement fixation
WO2007045465A1 (en) 2005-10-21 2007-04-26 F. Hoffmann-La Roche Ag Method for the recombinant expression of a polypeptide
EP1916257A1 (en) 2006-10-27 2008-04-30 Charite-Universitätsmedizin Berlin GD2 peptide mimotopes for anticancer vaccination
JP5654986B2 (ja) 2008-06-30 2015-01-14 モーフオテク・インコーポレーテツド 抗ｇｄ２抗体並びにそれに関連する方法及び使用
NZ603581A (en) 2010-06-19 2015-05-29 Sloan Kettering Inst Cancer Anti-gd2 antibodies
JP5623999B2 (ja) 2010-08-31 2014-11-12 パナソニック株式会社 電子装置
IN2014CN03887A (enExample) 2011-10-27 2015-10-16 Genmab As
WO2013189516A1 (en) 2012-06-18 2013-12-27 Apeiron Biologics Ag Method for treating a gd2 positive cancer
EP4218811A1 (en) 2012-06-18 2023-08-02 Apeiron Biologics AG Method for treating a gd2 positive cancer
US9840566B2 (en) 2013-11-21 2017-12-12 Apeiron Biologics Ag Preparations and methods for treating a GD2 positive cancer
EA201691055A1 (ru) 2013-11-21 2016-11-30 Апейрон Биолоджикс Аг Препараты и способы лечения gd2-положительного рака

Also Published As

Publication number Publication date
EP3620173A1 (en) 2020-03-11
EP3071220B1 (en) 2019-12-25
AU2014351796B2 (en) 2020-02-27
JP7139293B2 (ja) 2022-09-20
PT3071220T (pt) 2020-02-03
LT3071220T (lt) 2020-02-25
JP2016539122A (ja) 2016-12-15
EA201691055A1 (ru) 2016-11-30
AU2014351796A2 (en) 2016-08-11
NZ720273A (en) 2022-02-25
EP3071220A1 (en) 2016-09-28
HK1223039A1 (en) 2017-07-21
AU2014351796A1 (en) 2016-05-26
SI3071220T1 (sl) 2020-03-31
CY1122508T1 (el) 2021-05-05
US20200332021A1 (en) 2020-10-22
SMT202000027T1 (it) 2020-03-13
AU2020203346A1 (en) 2020-06-11
US20210221909A1 (en) 2021-07-22
PL3071220T3 (pl) 2020-05-18
JP2019218359A (ja) 2019-12-26
HRP20200128T1 (hr) 2020-05-15
US11492412B2 (en) 2022-11-08
DK3071220T3 (da) 2020-02-10
RS59817B1 (sr) 2020-02-28
US20240158530A1 (en) 2024-05-16
US10995147B2 (en) 2021-05-04
JP6693873B2 (ja) 2020-05-13
CA2930285A1 (en) 2015-05-28
WO2015075194A1 (en) 2015-05-28
HUE047920T2 (hu) 2020-05-28

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