ES276608A1 - A new steroid compound, processes for its preparation and pharmaceutical compositions thereof - Google Patents

A new steroid compound, processes for its preparation and pharmaceutical compositions thereof

Info

Publication number
ES276608A1
ES276608A1 ES0276608A ES276608A ES276608A1 ES 276608 A1 ES276608 A1 ES 276608A1 ES 0276608 A ES0276608 A ES 0276608A ES 276608 A ES276608 A ES 276608A ES 276608 A1 ES276608 A1 ES 276608A1
Authority
ES
Spain
Prior art keywords
trione
pregn
ene
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0276608A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES276608A1 publication Critical patent/ES276608A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 18-nor-pregn-4 - ene - 3,11,20-trione, 18-nor-pregna-3,11,20,-trione, pharmaceutical compositions thereof and processes for the preparation of 18-nor-pregn-4-ene-3,11,20-trione in which 18-nor-pregn-16-ene-3,11,20-trione is catalytically hydrogenated e.g. with palladium, to form 18-nor-pregna-3,11,20-trione, which is then brominated e.g. with free bromine, to form 4#x-bromo-18-nor-pregna-3,11,20-trione, which is dehydrobrominated e.g. with lithium bromide/lithium carbonate in N,N-dimethylformamide, to obtain the desired 18-nor-pregn-4-ene-3,11,20-trione. Said compositions having antilipaemic activity are administered orally, transcutaneously or rectally as tablets, pills, capsules, injectable solutions and suspensions, or suppositories.
ES0276608A 1961-04-19 1962-04-18 A new steroid compound, processes for its preparation and pharmaceutical compositions thereof Expired ES276608A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR859216A FR1288M (en) 1961-04-19 1961-04-19 New drug, in particular for the treatment of postprandial or acute hyperlipemia.

Publications (1)

Publication Number Publication Date
ES276608A1 true ES276608A1 (en) 1962-08-01

Family

ID=8753381

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0276608A Expired ES276608A1 (en) 1961-04-19 1962-04-18 A new steroid compound, processes for its preparation and pharmaceutical compositions thereof

Country Status (6)

Country Link
BE (1) BE616478A (en)
BR (1) BR6237939D0 (en)
CH (1) CH398583A (en)
ES (1) ES276608A1 (en)
FR (1) FR1288M (en)
GB (1) GB938072A (en)

Also Published As

Publication number Publication date
CH398583A (en) 1966-03-15
BR6237939D0 (en) 1973-06-28
FR1288M (en) 1962-05-07
GB938072A (en) 1963-09-25
BE616478A (en) 1962-08-16

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