ES272786A1 - Procedure for the manufacture of new derivatives of piperidine and its salts (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the manufacture of new derivatives of piperidine and its salts (Machine-translation by Google Translate, not legally binding)
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Roche Diagnostics GmbH
CF Boehringer und Soehne GmbH
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Boehringer Mannheim GmbH
CF Boehringer und Soehne GmbH
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Application filed by Boehringer Mannheim GmbH, CF Boehringer und Soehne GmbHfiledCriticalBoehringer Mannheim GmbH
Publication of ES272786A1publicationCriticalpatent/ES272786A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Process for the manufacture of new piperidine derivatives and their salts of the general formula I ** (See formula) ** wherein X means an oxygen atom or an alkylene radical (CH2) n with n = 0, 1 or 2, which can also be unsaturated if desired, A represents an alkylene radical of 2-4 C atoms of open chain or branched and Y means substituents ** (See formula) ** wherein the two R moieties are lower alkyl groups, which may also be linked together in the form of a common alkylene chain, characterized in that reactable esters of the general formula ** (See formula) ** wherein X and A have the above meaning and Z represents an acid radical, they are reacted with piperidine derivatives of formula III ** (See formula) ** in which Y has the above meaning, or in the inversion of this reaction, the condensation of amines of the general formula IV is carried out ** (See formula) ** wherein X has the above meaning, with reactable esters of the formula V ** (See formula) ** wherein Z, A and Y have the above meaning, after which, to the piperidon- (4) -acetals obtained from the formula I (see formula) hydrolyses, if necessary or if interested, in the corresponding piperidones (4) (Y: = 0) and these are reduced to the corresponding piperidinoles (4) (see formula), and the combinations obtained are transferred to their therapeutically applicable salts. (Machine-translation by Google Translate, not legally binding)
ES0272786A1960-12-091961-12-07Procedure for the manufacture of new derivatives of piperidine and its salts (Machine-translation by Google Translate, not legally binding)
ExpiredES272786A1
(en)
A procedure for the obtaining of i-phenoxy-2-hydroxy-butilaminopropanos etinil-substitute (Machine-translation by Google Translate, not legally binding)