ES2700901R1 - Proceso para la preparación de 3ß-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno. - Google Patents

Proceso para la preparación de 3ß-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno.

Info

Publication number
ES2700901R1
ES2700901R1 ES201990014A ES201990014A ES2700901R1 ES 2700901 R1 ES2700901 R1 ES 2700901R1 ES 201990014 A ES201990014 A ES 201990014A ES 201990014 A ES201990014 A ES 201990014A ES 2700901 R1 ES2700901 R1 ES 2700901R1
Authority
ES
Spain
Prior art keywords
androsta
benzimidazol
diene
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201990014A
Other languages
English (en)
Other versions
ES2700901A2 (es
ES2700901B2 (es
Inventor
Francesco Barbieri
Roberto Lenna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT102016000083406A external-priority patent/IT201600083406A1/it
Priority claimed from IT102016000121375A external-priority patent/IT201600121375A1/it
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of ES2700901A2 publication Critical patent/ES2700901A2/es
Publication of ES2700901R1 publication Critical patent/ES2700901R1/es
Application granted granted Critical
Publication of ES2700901B2 publication Critical patent/ES2700901B2/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES201990014A 2016-08-08 2017-08-08 Proceso para la preparación de 3ß-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno. Active ES2700901B2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102016000083406A IT201600083406A1 (it) 2016-08-08 2016-08-08 PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
IT102016000121375A IT201600121375A1 (it) 2016-11-30 2016-11-30 PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
PCT/EP2017/070124 WO2018029223A1 (en) 2016-08-08 2017-08-08 PROCESS FOR THE PREPARATION OF 3ß-HYDROXY-17-(1H-BENZIMIDAZOL-1-YL)ANDROSTA-5,16-DIENE

Publications (3)

Publication Number Publication Date
ES2700901A2 ES2700901A2 (es) 2019-02-19
ES2700901R1 true ES2700901R1 (es) 2019-03-04
ES2700901B2 ES2700901B2 (es) 2019-08-06

Family

ID=59745873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201990014A Active ES2700901B2 (es) 2016-08-08 2017-08-08 Proceso para la preparación de 3ß-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno.

Country Status (6)

Country Link
US (1) US11390645B2 (es)
CA (1) CA3063339C (es)
CH (1) CH714173B1 (es)
ES (1) ES2700901B2 (es)
RU (1) RU2749134C1 (es)
WO (1) WO2018029223A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024091899A1 (en) * 2022-10-25 2024-05-02 University Of Maryland, Baltimore Salts of galeterone and salts of next generation galeterone analogs, and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093993A1 (en) * 2005-03-02 2006-09-08 University Of Maryland Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2016119742A1 (zh) * 2015-01-29 2016-08-04 苏州晶云药物科技有限公司 (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017140183A1 (zh) * 2016-02-19 2017-08-24 深圳市塔吉瑞生物医药有限公司 一种取代的甾体类化合物及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093993A1 (en) * 2005-03-02 2006-09-08 University Of Maryland Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2016119742A1 (zh) * 2015-01-29 2016-08-04 苏州晶云药物科技有限公司 (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
V NJAR Y A BRODIE. Discovery and development of galeterone for the treatment of prostate cancer. Journal Medicinal Chemistry, 03/2015, Vol. 58, Páginas 2077-2087 esquema 1, páginas 2080,2081 *

Also Published As

Publication number Publication date
CA3063339C (en) 2024-05-28
US20210284681A1 (en) 2021-09-16
WO2018029223A1 (en) 2018-02-15
US11390645B2 (en) 2022-07-19
CH714173B1 (it) 2021-04-15
RU2749134C1 (ru) 2021-06-04
ES2700901A2 (es) 2019-02-19
CA3063339A1 (en) 2018-02-15
ES2700901B2 (es) 2019-08-06

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