ES2674451T3 - 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 - Google Patents

2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 Download PDF

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Publication number
ES2674451T3
ES2674451T3 ES13700849.6T ES13700849T ES2674451T3 ES 2674451 T3 ES2674451 T3 ES 2674451T3 ES 13700849 T ES13700849 T ES 13700849T ES 2674451 T3 ES2674451 T3 ES 2674451T3
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triazolo
pyrazin
ylamino
dimethyl
spiro
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Spanish (es)
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Carl Deutsch
Daniel Kuhn
Tatjana ROSS
Lars Burgdorf
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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ES13700849.6T 2012-02-21 2013-01-22 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 Active ES2674451T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001153 2012-02-21
EP12001153 2012-02-21
PCT/EP2013/000189 WO2013124026A1 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

Publications (1)

Publication Number Publication Date
ES2674451T3 true ES2674451T3 (es) 2018-06-29

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ES13700849.6T Active ES2674451T3 (es) 2012-02-21 2013-01-22 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2

Country Status (11)

Country Link
US (1) US9120804B2 (enExample)
EP (1) EP2817310B1 (enExample)
JP (2) JP6479476B2 (enExample)
CN (1) CN104114557B (enExample)
AR (1) AR090104A1 (enExample)
AU (1) AU2013224421B2 (enExample)
CA (1) CA2863723C (enExample)
ES (1) ES2674451T3 (enExample)
IL (1) IL233982A (enExample)
TW (1) TW201339165A (enExample)
WO (1) WO2013124026A1 (enExample)

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NO2699580T3 (enExample) 2014-01-24 2018-02-24
BR112017007164A2 (pt) * 2014-10-06 2017-12-19 A Anton Mark implantes de mama cobertos com politetrafluoroetileno expandido para minimizar reação capsular e infecção enquanto reduzindo palpabilidade
JP6948345B2 (ja) * 2016-04-29 2021-10-13 イオメット ファーマ リミテッド インドールアミン２，３−ジオキシゲナーゼ及び／又はトリプトファン−２，３−ジオキシゲナーゼの阻害薬としての新規置換イミダゾピリジン化合物
CN114989205A (zh) 2016-12-22 2022-09-02 卡里塞拉生物科学股份公司 用于抑制精氨酸酶活性的组合物和方法
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JP7229257B2 (ja) 2018-01-29 2023-02-28 メルク パテント ゲーエムベーハー Ｇｃｎ２阻害剤およびその使用
BR112020015396A2 (pt) 2018-01-29 2020-12-08 Merck Patent Gmbh Inididores de gcn2 e usos dos mesmos
CA3089240A1 (en) * 2018-02-07 2019-08-15 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating anca associated vasculitides
HUE070049T2 (hu) 2018-03-01 2025-05-28 Astrazeneca Ab (2S)-{(1S)-1-ciano-2-[4-(3-metil-2-oxo-2,3-dihidro-1,3-benzoxazol-5-il)fenil]etil} -1,4-oxazepán-2-karboxamidot tartalmazó gyógyászati készítmények
JP7220204B2 (ja) * 2018-03-27 2023-02-09 本田技研工業株式会社 フッ化物イオン二次電池用正極活物質、当該活物質を用いた正極、およびフッ化物イオン二次電池、並びに当該活物質の製造方法
EP3781156A4 (en) 2018-04-16 2022-05-18 C4 Therapeutics, Inc. SPIROCYCLIC COMPOUNDS
EP3556760A1 (en) * 2018-04-19 2019-10-23 F. Hoffmann-La Roche AG Spiro compounds
EP3578561A1 (en) * 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
WO2020018547A1 (en) 2018-07-17 2020-01-23 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN113929678B (zh) * 2020-07-14 2025-09-30 武汉朗来科技发展有限公司 一种rock抑制剂及其制备方法和用途
WO2022238816A1 (en) * 2021-05-14 2022-11-17 Bm Pharma Consulting Pty. Ltd Bicyclic heterocyclic compounds for prophylaxis and treatment of viral infections
AU2022299051B2 (en) * 2021-06-23 2025-03-13 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR102659126B1 (ko) * 2022-03-24 2024-04-19 충남대학교산학협력단 항결핵 약학조성물
JP2026503035A (ja) 2023-01-06 2026-01-27 インスメッド インコーポレイテッド 新規な可逆性ｄｐｐ１阻害剤及びその用途

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