ES2672509T3 - Forma polimórfica cristalina de acetato de ulipristal - Google Patents

Forma polimórfica cristalina de acetato de ulipristal Download PDF

Info

Publication number
ES2672509T3
ES2672509T3 ES13792105.2T ES13792105T ES2672509T3 ES 2672509 T3 ES2672509 T3 ES 2672509T3 ES 13792105 T ES13792105 T ES 13792105T ES 2672509 T3 ES2672509 T3 ES 2672509T3
Authority
ES
Spain
Prior art keywords
polymorphic form
crystalline polymorphic
ulipristal acetate
diffraction
ulipristal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13792105.2T
Other languages
English (en)
Inventor
Shigeki Iwashita
Hiroyuki Hayashi
Koichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Aska Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aska Pharmaceutical Co Ltd filed Critical Aska Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2672509T3 publication Critical patent/ES2672509T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/08—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epidemiology (AREA)

Abstract

Una forma polimórfica cristalina C de acetato de ulipristal que tiene un patrón de difracción de rayos X de polvo que comprende picos de difracción a los siguientes ángulos 2 theta de difracción: 9,0+-0,2º, 9,3+-0,2º, 10,8+-0,2º, 11,5+-0,2º, 12,2+-0,2º, 13,1+-0,2º, 14,35 +-0,2º, 15,6+-0,2º, 15,7+-0,2º, 15,9+-0,2º, 16,6+-0,2º, 17,6+-0,2º, 17,9+-0,2º, 18,9+-0,2º, 19,3+-0,2º, 23,8+-0,2º.
ES13792105.2T 2012-09-28 2013-09-26 Forma polimórfica cristalina de acetato de ulipristal Active ES2672509T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012215436 2012-09-28
JP2012215436 2012-09-28
PCT/JP2013/005709 WO2014050106A1 (en) 2012-09-28 2013-09-26 Crystalline polymorphic form of ulipristal acetate

Publications (1)

Publication Number Publication Date
ES2672509T3 true ES2672509T3 (es) 2018-06-14

Family

ID=49585551

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13792105.2T Active ES2672509T3 (es) 2012-09-28 2013-09-26 Forma polimórfica cristalina de acetato de ulipristal

Country Status (9)

Country Link
US (1) US9643993B2 (es)
EP (1) EP2900683B1 (es)
JP (1) JP6474722B2 (es)
KR (1) KR20150063486A (es)
AU (1) AU2013321890B2 (es)
CA (1) CA2885795A1 (es)
ES (1) ES2672509T3 (es)
IL (1) IL237824B (es)
WO (1) WO2014050106A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017014844A (es) * 2015-05-18 2018-02-19 Bayer Pharma AG Regimen modulador selectivo de los receptores de progesterona (sprm).

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US5929262A (en) 1995-03-30 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
ES2212912B1 (es) * 2003-01-22 2005-10-01 Crystal Pharma, S.A. Procedimiento para la obtencion de 17alfa-acetoxi-11beta-(4-n,n-dimetilaminofenil)-19-norpregna-4,9-dien-3,20-diona.
AU2004217988C1 (en) 2003-02-28 2010-06-03 Southwest Foundation For Biomedical Research Method for preparing 17 alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
HU227112B1 (hu) 2006-06-14 2010-07-28 Richter Gedeon Nyrt Ipari eljárás 17-alfa-acetoxi-11-béta-[4-(N,N-dimetil-amino)-fenil]-19-norpregna-4,9-dién-3,20-dion elõállítására és új intermedierek az eljáráshoz
SI2419108T1 (sl) 2009-04-14 2017-02-28 Laboratorie Hra Pharma Metoda za kontracepcijo na zahtevo
CN103193850A (zh) 2012-01-04 2013-07-10 北京紫竹药业有限公司 甾体化合物的新晶型及其制备方法
CN102675395B (zh) 2012-04-17 2014-04-30 常州市第四制药厂有限公司 醋酸乌利司他的多晶型及其制备方法
CN102887931B (zh) 2012-07-07 2015-04-15 山东诚创医药技术开发有限公司 一种醋酸乌利司他的结晶体及其制备方法
JP6200493B2 (ja) * 2012-09-28 2017-09-20 あすか製薬株式会社 無定形ウリプリスタール酢酸エステル
CA2885798A1 (en) * 2012-09-28 2014-04-03 Aska Pharmaceutical Co., Ltd. Crystalline polymorphic form of ulipristal acetate

Also Published As

Publication number Publication date
IL237824B (en) 2019-03-31
EP2900683A1 (en) 2015-08-05
EP2900683B1 (en) 2018-03-14
WO2014050106A1 (en) 2014-04-03
CA2885795A1 (en) 2014-04-03
AU2013321890A1 (en) 2015-04-09
US20150239927A1 (en) 2015-08-27
JP6474722B2 (ja) 2019-02-27
AU2013321890B2 (en) 2017-05-18
KR20150063486A (ko) 2015-06-09
US9643993B2 (en) 2017-05-09
JP2015531340A (ja) 2015-11-02

Similar Documents

Publication Publication Date Title
NO2022010I1 (no) ripretinib, or a pharmaceutically acceptable salt thereof
FIC20240022I1 (fi) Retsafungiini tai sen farmaseuttisesti hyväksyttävä suola, erityisesti retsafungiiniasetaatti
HK1178387A1 (zh) 種凝膠、含它的耐溫型軟糖及其製備方法
TWI562991B (en) Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
EP3074010A4 (en) Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
BR112013024491A2 (pt) neuroestimulador.
ZA201304207B (en) Indeno-fused ring compounds
MX2015002040A (es) Baricitinib deuterado.
PL2674034T3 (pl) Sposób wytwarzania oleju z kryla i olej z kryla wytwarzany tym sposobem
EP2699091A4 (en) 2 ', 6'-dioxo-3'-deutero-PIPERIDIN-3-YL-isoindoline COMPOUNDS
CO6960553A2 (es) Fluorometil-5,6-dihidro-4h-[1,3]oxazinas
ITAN20120150A1 (it) Servomeccanismo per l'apertura di una serratura.
AR103444A1 (es) Forma cristalina de un derivado de bencimidazol y un método de preparación de los mismos
ES1076496Y (es) Conjunto para formación de cápsulas rellenables para preparación de infusiones.
ZA201403519B (en) Drought tolerant plants produced by modification of the stay-green stgx locus
EP3004120A4 (en) Spiro-1,1'-biindane-7,7-bisphosphine oxides as highly active supporting ligands for palladium-catalyzed asymmetric heck reaction
MX2015008829A (es) Momelotinib deuterado.
DK3284479T3 (da) Fremgangsmåde til fremstilling af medikamenter til bekæmpelse af tumorer
PH12015502122A1 (en) Sovaprevir polymorphs and methods of manufacturing thereof
CL2013000688A1 (es) Procedimiento para obtener una composicion de igg a partir de una composicion de igg parcialmente purificada.
BR112012025490A2 (pt) ''método para produção de 1,5 oebtanodiamina''
EP2883870B8 (en) Method for producing 1,4-benzoxazine compound
ES2672509T3 (es) Forma polimórfica cristalina de acetato de ulipristal
ES2492673T3 (es) Formas cristalinas de un ingrediente farmacéutico activo
EP3085701A4 (en) N, n' substituted piperidinamine compounds, and preparation method and usage thereof